Abstract: A foldout bed is described. The foldout bed has a left side wall, a right side wall, and a top panel that extends between and attached to the top ends of the two side walls. The bottom end of each side wall is coupled with a counterbalance mechanism. A bed tray is pivotally coupled with a the counterbalance mechanisms and is transitionable between an open configuration and a closed configuration. The bed tray provides a unitary planar surface that is configured to support a mattress and a person when in the open configuration. Each counterbalance mechanism has a frame and a piston that attaches the frame to the bed tray. The frame has a base flange disposed perpendicular to the side walls and located at the bottommost end of the counterbalance mechanism against a base plate of the wall.

Abstract: A foldout bed is described. The foldout bed has a left side wall, a right side wall, and a top panel that extends between and attached to the top ends of the two side walls. The bottom end of each side wall is coupled with a counterbalance mechanism. A bed tray is pivotally coupled with a the counterbalance mechanisms and is transitionable between an open configuration and a closed configuration. The bed tray provides a unitary planar surface that is configured to support a mattress and a person when in the open configuration. Each counterbalance mechanism has a frame and a piston that attaches the frame to the bed tray. The frame has a base flange disposed perpendicular to the side walls and located at the bottommost end of the counterbalance mechanism against a base plate of the wall.

Abstract: A foldout bed housing with four panels is described. The housing includes a bed tray comprising a first panel, a second panel, a third panel, and a fourth panel, wherein the first and second panels are hingeably coupled and the third and fourth panels are hingeably coupled, and one or more fasteners for rigidly coupling the first and second panels with the third and fourth panels in a planar surface. The housing also includes a first and second side wall, a front panel, a first back panel, a top panel, and a counterbalance mechanism. Each housing component can be shipped in a packed configuration for economic shipping. Upon delivery, the combination can be unpacked for quick and easy installation.

Abstract: Various embodiments set forth a computer-implemented method for selectively caching digital content for streaming, comprising analyzing a set of traffic data associated with streaming of a plurality of media items in a first time period, selecting, based on the set of traffic data, a first media item for storage in a cache during a second time period, and storing in the cache, prior to receiving a request for the first media item in the second time period, at least a portion of a first media stream of a plurality of media streams associated with the first media item, and at least a portion of a second media stream of the plurality of media streams, wherein each media stream in the plurality of media streams is encoded with different characteristics.

Abstract: Various embodiments set forth a computer-implemented method for selectively caching digital content for streaming, comprising analyzing a set of traffic data associated with streaming of a plurality of media items in a first time period, selecting, based on the set of traffic data, a first media item for storage in a cache during a second time period, and storing in the cache, prior to receiving a request for the first media item in the second time period, at least a portion of a first media stream of a plurality of media streams associated with the first media item, and at least a portion of a second media stream of the plurality of media streams, wherein each media stream in the plurality of media streams is encoded with different characteristics.

Abstract: A foldout bed housing with four panels is described. The housing includes a bed tray comprising a first panel, a second panel, a third panel, and a fourth panel, wherein the first and second panels are hingeably coupled and the third and fourth panels are hingeably coupled, and one or more fasteners for rigidly coupling the first and second panels with the third and fourth panels in a planar surface. The housing also includes a first and second side wall, a front panel, a first back panel, a top panel, and a counterbalance mechanism. Each housing component can be shipped in a packed configuration for economic shipping. Upon delivery, the combination can be unpacked for quick and easy installation.

Abstract: A foldout cabinet bed has two faces that fold out from a vertical position to a horizontal position, thereby creating a surface that can be used for sleeping. Each face has two side rails for enclosing an area for placing a mattress. The rails are dimensionally asymmetrical such that one of the faces has a smaller rail height/depth than the adjacent rail on the other face. The shorter rail height is smaller than the thickness of the mattress, thus allowing a user to comfortably sit on the edge of the mattress. The taller rail height is larger than the thickness of the mattress and provides a headboard.

Abstract: A foldout bed assembly with bifold doors is described. The assembly includes a first door that folds along a first seam to reduce the width of the first door. The first door is hingeably coupled with a first side wall such that the door and side wall can be folded together in an accordion fashion. The door and side wall combination can also be folded along a third seam that is perpendicular to the first and second seams. The third seam allows for reduction of the height of the unit. The foldout bed assembly includes a second door and second side wall that is similar in construction as the first door and first side wall (e.g., left and right doors). Each door and side wall combination can be shipped in a folded configuration for economic shipping. Upon delivery, the combination can be unfolded for quick and easy installation.

Abstract: Mattress systems for a wall bed are disclosed. In one embodiment, the mattress system includes a mattress having a top face, an inner layer and a bottom face, and a panel placed on the bottom surface. The panel is coupled with wires, which passes through the inner layer of the mattress so that the other end is coupled with the top surface of the mattress. Another embodiment of the mattress system includes a pillow stabilization mechanism that includes a panel placed on the bottom surface and an adjustable strap. Still another embodiment of the mattress system includes a dip prevention mechanism that includes a panel placed on the bottom surface which is sized and dimensioned to prevent the bottom face from having a dip when the mattress is placed on a slat.

Abstract: A foldout bed assembly with bifold doors is described. The assembly includes a first door that folds along a first seam to reduce the width of the first door. The first door is hingeably coupled with a first side wall such that the door and side wall can be folded together in an accordion fashion. The door and side wall combination can also be folded along a third seam that is perpendicular to the first and second seams. The third seam allows for reduction of the height of the unit. The foldout bed assembly includes a second door and second side wall that is similar in construction as the first door and first side wall (e.g., left and right doors). Each door and side wall combination can be shipped in a folded configuration for economic shipping. Upon delivery, the combination can be unfolded for quick and easy installation.

Abstract: A foldout bed having two frames is described. Two frames are hingeably coupled with each other at a pivot point, by which the two frames are transitionable between a coplanar configuration and a non-coplanar configuration. Two frames are also coupled by a counterbalance mechanism, which couples one frame to a lower member of the other frame such that the counterbalance mechanism does not extend beyond a front-most surface of the other frame. The foldout bed also has two panels, each of which couples with one of the two frames, respectively. The distance between two panels forms a gap that is sized and dimensioned to allow the two frames to transition between the coplanar and non-coplanar configuration without encumbrance. The gap is covered by a gap cover.

Abstract: A foldout cabinet bed has two faces that fold out from a vertical position to a horizontal position, thereby creating a surface that can be used for sleeping. Each face has two side rails for enclosing an area for placing a mattress. The rails are dimensionally asymmetrical such that one of the faces has a smaller rail height/depth than the adjacent rail on the other face. The shorter rail height is smaller than the thickness of the mattress, thus allowing a user to comfortably sit on the edge of the mattress. The taller rail height is larger than the thickness of the mattress and provides a headboard.

Abstract: The invention relates to a method of treating mucopolysaccharidoses using enzyme replacement therapy with chemically modified lysosomal enzymes. More specifically the method relates to administering chemically modified lysosomal enzymes intraperitoneal injection. In addition, the invention relates to treating type VII mucopolysaccharidoses or mucopolysaccharidoses type VII related bone lesions with a chemical modified ?-glucuronidase, wherein the modified ?-glucuronidase may be administered 5 weeks after birth, and or may be administered intraperitoneally.

Abstract: The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue.

Abstract: A rolling foldout cabinet bed has two faces that fold out from a vertical to a horizontal position, thereby creating a surface that can be used for sleeping. When the cabinet is closed, a space within the cabinet stores a foldable innerspring, or other mattress. The two faces can be locked together in the folded position. During deployment, an elastic belt or other retainer and hold the folded mattress to one of the faces, and can also pull the mattress out of the interior space within the bottom of the cabinet. The cabinet also has legs for supporting the faces above the ground when in the opened configuration, and can include wheels that facilitate moving the cabinet quickly and easily moved.

Abstract: A rolling foldout cabinet bed has two faces that fold out from a vertical to a horizontal position, thereby creating a surface that can be used for sleeping. When the cabinet is closed, a space within the cabinet stores a foldable innerspring, or other mattress. The two faces can be locked together in the folded position. During deployment, an elastic belt or other retainer and hold the folded mattress to one of the faces, and can also pull the mattress out of the interior space within the bottom of the cabinet. The cabinet also has legs for supporting the faces above the ground when in the opened configuration, and can include wheels that facilitate moving the cabinet quickly and easily moved.

Abstract: The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue.

Abstract: The invention is directed to chimeral fusion proteins having an IgG1 antibody Fc portion and a lysosomal storage enzyme, particularly a Fc-GUS fusion protein useful in treating Sly's disease in an embryo or fetus. The invention is also directed to methods of treating in born errors of metabolism, particularly Sly's disease, in a fetus by delivering to a pregnant mother a Fc-MPS emzyme fusion protein.

Abstract: The present invention provides a polypeptide therapeutic agent, useful in enzyme replacement therapy, with increased therapeutic benefits for the central nervous system. The invention provides a method of enhancing the effect of a polypeptide or protein on the central nervous system by the attachment of a short acidic amino acid sequence. Specifically the inventors disclose the attachment of a 4-15 acidic amino acid sequence to human ?-glucuronidase by construction of a fusion protein. This molecule is useful in the treatment of type VII mucopolysaccharidosis when administered to a patient.

Abstract: Disclosed are a fusion protein comprising enzyme ?-glucuronidase and short peptide consisting 4-15 acidic amino acids attached to the enzyme on its N-terminal side, pharmaceutical composition containing the fusion protein, and a method for treatment of type VII mucopolysaccharidosis using the fusion protein. Compared with the native enzyme, the fusion protein exhibits higher stability in the blood.