Abstract: Described herein are methods of applying metals to substrates, where the methods include contacting the substrate with an aqueous metal plating composition comprising polyammonium bisulfate (“PABS”) and a dissolved metal or salt thereof. The methods allow application of metals to the substrate without need for electrical energy input or for an added chemical catalyst, chelating agent, complexing agent, reducing agent, stabilizer, or pH-modifying (or controlling) chemical compound.

Abstract: An energy generator includes a plurality of energy sources. Each energy source includes: a power supply configured to output a direct current waveform; an inverter coupled to the power supply and configured to generate an electrosurgical waveform or an ultrasonic drive waveform; and an energy source controller configured to control the inverter and the power supply. The generator also includes a plurality of receptacles each of which is coupled to the plurality of energy sources. Each receptacle includes a plurality of ports, where a first portion of the ports is configured to transmit the electrosurgical waveform and a second portion of the ports is configured to transmit the ultrasonic drive waveform.

Abstract: A surgical energy delivery system includes an energy delivery instrument with a plug having a substrate including one or more first plug contacts and one or more second plug contacts. The plug also includes an insertion portion. The system also includes an energy generator having a connector configured to couple to the plug. The connector includes a first portion having one or more first connector contacts and a second portion having one or more second connector contacts. Each of the first portion and the second portion is pivotable from a first position to a second position, in which the first portion and second portion are configured to engage the plug and the first connector contact(s) to electrically couple to the first plug contact(s) and the second connector contact(s) to electrically couple to the second plug contact(s).

Abstract: Novel systems for and methods of delivering therapeutic agents to target tissues are disclosed. The method of delivering a therapeutic agent to a target tissue involves identifying a target tissue via an imaging modality and then using a guidewire capable of anchoring in tissue to advance a cannula to the target tissue. The guidewire and novel cannula configurations enable rapid and repeated treatments of the target tissue without the need for subsequent imaging. The cannula is coupled to a source of ultrasound, radiation, radiofrequency energy, or chemotherapeutic agents which can then be delivered to from the cannula the target tissue. The system and method can be used to treat tumors that are small or surgically inoperable. In addition, the system can be used to treat lymphatic tissue that may contain metastases from the tumors.

Abstract: Novel systems for and methods of delivering therapeutic agents to target tissues are disclosed. The method of delivering a therapeutic agent to a target tissue involves identifying a target tissue via an imaging modality and then using a guidewire capable of anchoring in tissue to advance a cannula to the target tissue. The guidewire and novel cannula configurations enable rapid and repeated treatments of the target tissue without the need for subsequent imaging. The cannula is coupled to a source of ultrasound, radiation, radiofrequency energy, or chemotherapeutic agents which can then be delivered to from the cannula the target tissue. The system and method can be used to treat tumors that are small or surgically inoperable. In addition, the system can be used to treat lymphatic tissue that may contain metastases from the tumors.

Abstract: Novel systems for and methods of delivering therapeutic agents to target tissues are disclosed. The method of delivering a therapeutic agent to a target tissue involves identifying a target tissue via an imaging modality and then using a guidewire capable of anchoring in tissue to advance a cannula to the target tissue. The guidewire and novel cannula configurations enable rapid and repeated treatments of the target tissue without the need for subsequent imaging. The cannula is coupled to a source of ultrasound, radiation, radiofrequency energy, or chemotherapeutic agents which can then be delivered to from the cannula the target tissue. The system and method can be used to treat tumors that are small or surgically inoperable. In addition, the system can be used to treat lymphatic tissue that may contain metastases from the tumors.

Abstract: A system for perfusing a biological organ for use as an experimental model includes a housing having sides that define a cavity for containing a biological organ model within a solution. The housing includes a plurality of apertures defined therethrough configured to mechanically interface with a filter, one or more heating elements and one or more sensors. A peristaltic pump is configured to withdraw and pressurize the solution from the housing and reintroduce the solution under pressure into the biological organ. A heat control module operatively connects to the heating elements and is configured to regulate the temperature of the solution within the housing. A data acquisition system operatively connects to the heat control module, the peristaltic pump and the sensor(s) and regulates and monitors the pressure, flow rate and temperature of the solution during electrical treatment of the biological organ.

Abstract: A system for perfusing a biological organ for use as an experimental model includes a housing having sides that define a cavity for containing a biological organ model within a solution. The housing includes a plurality of apertures defined therethrough configured to mechanically interface with a filter, one or more heating elements and one or more sensors. A peristaltic pump is configured to withdraw and pressurize the solution from the housing and reintroduce the solution under pressure into the biological organ. A heat control module operatively connects to the heating elements and is configured to regulate the temperature of the solution within the housing. A data acquisition system operatively connects to the heat control module, the peristaltic pump and the sensor(s) and regulates and monitors the pressure, flow rate and temperature of the solution during electrical treatment of the biological organ.

Abstract: A hemostat comprises a non-porous patch made of a bio-resorbable tissue compatible material, said patch having a tissue-facing surface and a top surface; an optional hemostatic agent that is disposed on said tissue-facing surface or optionally dispersed throughout said patch or optionally as a separate carrier layer, and at least one aperture or slit that penetrates said patch at least partially from said tissue-facing surface to said top surface.

Abstract: Methods are provide to allow for the preparation of adenoviral vectors with altered tropism. Compositions comprising such vectors and methods of use thereof also are provided.

Abstract: A receptacle assembly for use in connecting an energy source to an energy delivering device is described herein. The receptacle assembly includes a face plate defining an aperture. The receptacle also includes an adapter assembly including an adapter plate, supporting a terminal that is operatively connected to the energy source. Additionally, the receptacle includes a spacer member interposed between an inner surface of the aperture of the face plate and an outer surface of the adapter plate, wherein the spacer member permits omni-directional movement of the adapter plate and terminal relative to the face plate.

Abstract: Methods are provide to allow for the preparation of adenoviral vectors with altered tropism. Compositions comprising such vectors and methods of use thereof also are provided.

Abstract: A system for perfusing a biological organ for use as an experimental model includes a housing having sides that define a cavity for containing a biological organ model within a solution. The housing includes a plurality of apertures defined therethrough configured to mechanically interface with a filter, one or more heating elements and one or more sensors. A peristaltic pump is configured to withdraw and pressurize the solution from the housing and reintroduce the solution under pressure into the biological organ. A heat control module operatively connects to the heating elements and is configured to regulate the temperature of the solution within the housing. A data acquisition system operatively connects to the heat control module, the peristaltic pump and the sensor(s) and regulates and monitors the pressure, flow rate and temperature of the solution during electrical treatment of the biological organ.

Abstract: A receptacle assembly for use in connecting an energy source to an energy delivering device is described herein. The receptacle assembly includes a face plate defining an aperture. The receptacle also includes an adapter assembly including an adapter plate, supporting a terminal that is operatively connected to the energy source. Additionally, the receptacle includes a spacer member interposed between an inner surface of the aperture of the face plate and an outer surface of the adapter plate, wherein the spacer member permits omni-directional movement of the adapter plate and terminal relative to the face plate.

Abstract: A receptacle assembly for use in connecting an energy source to an energy delivering device is described herein. The receptacle assembly includes a face plate defining an aperture. The receptacle also includes an adapter assembly including an adapter plate, supporting a terminal that is operatively connected to the energy source. Additionally, the receptacle includes a spacer member interposed between an inner surface of the aperture of the face plate and an outer surface of the adapter plate, wherein the spacer member permits omni-directional movement of the adapter plate and terminal relative to the face plate.

Abstract: A receptacle assembly for use in connecting an energy source to an energy delivering device is described herein. The receptacle assembly includes a face plate defining an aperture. The receptacle also includes an adapter assembly including an adapter plate, supporting a terminal that is operatively connected to the energy source. Additionally, the receptacle includes a spacer member interposed between an inner surface of the aperture of the face plate and an outer surface of the adapter plate, wherein the spacer member permits omni-directional movement of the adapter plate and terminal relative to the face plate.

Abstract: This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinant of Hog Cholera Virus or Pseudorabies virus. The further invention relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting pigs from disease.

Abstract: A simulation of an electronics system which performs a set of operations of interest. A simulated supervisory circuit detects a state in which all the operations have been completed, and also determines the amount of time until the occurrence of the next relevant event. Simulation time is then advanced by that amount of time. This enables simulation time corresponding to an inactive system to be eliminated.

Abstract: This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinant of Hog Cholera Virus or Pseudorabies virus. The further invention relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting pigs from disease.