Abstract: A frequency multiplier circuit includes a first multiplier circuit to generate a first digital value representing a received reference signal having a reference frequency and reference phase, the multiplier circuit to multiply the first digital value by a multiplier value. Comparison circuitry compares the first digital value to an output digital value representing an output signal having an output frequency and an output phase, the comparison circuitry to generate an error signal based on the comparison. A programmable loop filter generates a control signal based at least in part on the error signal. A frequency generation circuit produces the output signal having the output frequency and phase. A phase-to-digital converter generates and feeds the output digital value to the phase comparison circuitry. A programmable transition controller controls a transitioning frequency relationship between a first signal frequency of a first locked output signal and a desired second signal frequency.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: A method for conditionally redeeming transportation credits through a transportation credit program having a sponsor may include verifying, through a validation network provider across a computer network, a recipient's eligibility for a transportation credit having one or more redemption conditions, issuing the transportation credit to the recipient, transmitting the transportation credit to a transportation service provider through the validation network provider across the computer network, and enforcing one or more of the redemption conditions by monitoring one or more of the redemption conditions using a mobile computing device.

Abstract: A method for conditionally redeeming transportation credits through a transportation credit program having a sponsor may include verifying, through a validation network provider across a computer network, a recipient's eligibility for a transportation credit having one or more redemption conditions, issuing the transportation credit to the recipient, transmitting the transportation credit to a transportation service provider through the validation network provider across the computer network, and enforcing one or more of the redemption conditions by monitoring one or more of the redemption conditions using a mobile computing device.

Abstract: An interactive centerpiece system includes a plurality of tablet computers with interactive display devices for displaying slideshows of photograph image data. A substantially flat base with opposing upper and lower surfaces is also provided. The base is formed to lay flat on a table in a table position whereat a base central axis that is perpendicular to both the upper and lower surfaces substantially aligns with a geometric center of the table, to surround a surface area defined by an outer perimeter, about which the plurality of docking stations, into which one of the tablet computers is fixed, are arranged at substantially equal distances from each other. The docking stations are configured to face the interactive display devices outward and define a usable area between the docking stations and the base central axis for uses including receiving traditional event centerpieces.

Abstract: An interactive centerpiece system includes a plurality of tablet computers with interactive display devices for displaying slideshows of photograph image data. A substantially flat base with opposing upper and lower surfaces is also provided. The base is formed to lay flat on a table in a table position whereat a base central axis that is perpendicular to both the upper and lower surfaces substantially aligns with a geometric center of the table, to surround a surface area defined by an outer perimeter, about which the plurality of docking stations, into which one of the tablet computers is fixed, are arranged at substantially equal distances from each other. The docking stations are configured to face the interactive display devices outward and define a usable area between the docking stations and the base central axis for uses including receiving traditional event centerpieces.

Abstract: An interactive centerpiece system includes a plurality of tablet computers with interactive display devices for displaying slideshows of photograph image data. A substantially flat base with opposing upper and lower surfaces is also provided. The base is formed to lay flat on a table in a table position whereat a base central axis that is perpendicular to both the upper and lower surfaces substantially aligns with a geometric center of the table, to surround a surface area defined by an outer perimeter, about which the plurality of docking stations, into which one of the tablet computers is fixed, are arranged at substantially equal distances from each other. The docking stations are configured to face the interactive display devices outward and define a usable area between the docking stations and the base central axis for uses including receiving traditional event centerpieces.

Abstract: Methods, systems, and apparatus used to determine whether to discard a network packet based upon the latency exhibited by an associated a network packet queue. Network devices can include a queue management module operable to identify a latency metric in network packet queues and determine whether the latency metric renders the network packet queue eligible for discarding packets based upon, for example, a latency policy.

Abstract: A translation agent adapts DOCSIS information, primarily QoS information, for transmission over a PON. The agent places into an IP address field of a DHCP message the MAC address of an ONU associated with a CPE device attempting to register with a CMTS. The translation agent intercepts DHCP reply messages from the DHCP server using the MAC address of the ONU. The translation agent extracts information, including an IP address of the client CPE assigned by the DHCP server. The agent downloads a configuration file for the CPE device using the configuration filename and configuration file server contained in a DHCP reply message. Information contained in the configuration file is converted from content in a format used by DOCSIS, to content in a format used by PON devices. The translated content includes QoS parameters, functions related to which are controlled at the ONU by an OLT coupled to the CMTS.

Abstract: A token bucket instantiation regulate packets in a traffic flow stream based on a predetermined peak traffic flow rate. The token bucket size is nominally set to zero. An evaluation is made at a device that has received a given packet. The packet is considered conforming and is passed from the device if the token depth of the bucket is zero or greater. The token depth is decreased by the number of byes in the packet that was passed. The token depth is continuously replenished at a predetermined token rate until the predetermined bucket size is attained (the bucket is full). A received packet is deemed nonconforming if the token depth is less than zero; the non-conforming packet is not passed but is processed according to non-conforming criteria. Token bucket instantiations may be implemented in hardware, software or firmware for each traffic flow to regulate traffic to a given user.

Abstract: Methods, systems, and apparatus used to determine whether to discard a network packet based upon the latency exhibited by an associated a network packet queue. Network devices can include a queue management module operable to identify a latency metric in network packet queues and determine whether the latency metric renders the network packet queue eligible for discarding packets based upon, for example, a latency policy.

Abstract: In a data system, such as a cable modem termination system, different-priority flows are scheduled to be routed to their logical destinations by factoring both the priority level and the time spent in queue. The time that each packet of each flow spends waiting for transmission is normalized such that the waiting times of all flows are equalized with respect to each other. A latency scaling parameter is calculated.

Abstract: The present invention relates to recombinant human BACE polypeptides. More particularly, the invention relates to recombinant human BACE polypeptides that have a modified amino acid sequence at position 33 of the BACE sequence, as well as to polynucleotides, expression vectors, host cells, and methods for producing the modified recombinant human BACE polypeptides.

Abstract: The present invention relates to recombinant human BACE polypeptides. More particularly, the invention relates to recombinant human BACE polypeptides that have a modified amino acid sequence at position 33 of the BACE sequence, as well as to polynucleotides, expression vectors, host cells, and methods for producing the modified recombinant human BACE polypeptides.

Abstract: A DOCSIS set-top gateway device uses multiple embedded cable modems so that one eCM can remained tuned to a frequency being used for a current two-way data session and another eCM can be used to tune to a different frequency. The other eCM that tunes to a different frequency is disabled from operating in the upstream direction to avoid conflict with the two-way eCM in communicating with a CMTS. The eCMs in the DSG are controlled by a client controller that interfaces applications local to the DSG to a central device, such as a CMTS. A message may be sent to a client application requesting content on a traffic flow using a different frequency than the two-way capable sCM. The client controller instructs the upstream-disabled eCM to tune to the different frequency, meanwhile the two-way eCM stays tuned to the current frequency.

Abstract: A token bucket instantiation regulate packets in a traffic flow stream based on a predetermined peak traffic flow rate. The token bucket size is nominally set to zero. An evaluation is made at a device that has received a given packet. The packet is considered conforming and is passed from the device if the token depth of the bucket is zero or greater. The token depth is decreased by the number of byes in the packet that was passed. The token depth is continuously replenished at a predetermined token rate until the predetermined bucket size is attained (the bucket is full). A received packet is deemed nonconforming if the token depth is less than zero; the non-conforming packet is not passed but is processed according to non-conforming criteria. Token bucket instantiations may be implemented in hardware, software or firmware for each traffic flow to regulate traffic to a given user.

Abstract: TFTP server address, configuration file name and relay agent address contained in a DHCPACK are recorded; the TFTP server address is overwritten with the relay agent address before forwarding. Upon receipt of a TFTP request, a transfer identifier is selected from a pool of available port values, and the source address/port pair and relay agent's address are associated therewith. The relay agent's address and the transfer identifier replace the source address/port pair, and a check is made to determine whether the cable modem is requesting the correct configuration file. Action may be taken if the CM requests an incorrect filename, or if configuration TLVs are incorrect. The relay agent retrieves the TFTP server's address/port pair from the first TFTP data packet received, and associates these with the transfer identifier before returning it to the available pool. The transfer identifier is used to lookup the CM address/port pair.

Abstract: A web advertiser may geographically target internet display advertising by selecting geographic parameters. Fragments of geographic location data are supplied by or inferred about a computer user accessing a web publisher's web site. User information is transmitted by the web publisher to an advertising server, where it is supplemented by comparison with a geographic information database. User information is then compared to geographic parameters supplied by the advertiser. If a match is found, a geographically-targeted advertisement is transmitted to the user. If no match is found, a default advertisement is transmitted to the user. Advertising inventory from many advertisers may be aggregated on the advertising server and delivered through many web publishers to users in specified geographic locations.

Abstract: A long-term usage profile and a congestion state metric are used to determine QoS treatment to apply to packets corresponding to a given network user. A user's historical long-term use, measured over one or more periods of time, is used to generate a profile that is compared to one or more predetermined usage threshold level(s). If the usage profile, either singular or composite corresponding to whether one or more than one measurement is used respectively, exceeds the threshold(s), QoS treatment is applied to service flow bytes according to the comparison results during times of network channel congestion. Congestion metrics are determined based on a count of the number of bytes dropped during a congestion measurement window. Either the count itself or the count rate of change combined with the count are compared to a congestion threshold. If the measured/derived values exceed a congestion threshold, the channel is deemed congested.

Abstract: A subscriber login server is used for managing a subscriber login session. The login server is associated with a DHCP server for configuring a premise equipment device and operator-managed device. A subscriber login client at the premise equipment device securely communicates login username and password identifiers to the subscriber login server without using PPP technology. The login server retrieves matching identifiers from a RADIUS server and authorizes service with messages to the DHCP server and the CMTS. The login client can emulate a PPP login client so that a user's interface is similar to a PPPoE client. However, a layer-3 CMTS can be used instead of a layer-2 CMTS. In addition, subscriber authentication and accounting using RADIUS are preserved, positive network access control at the CMTS is maintained, and native IP traffic is routed or switched for maximum performance and QoS treatment.