Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Systems and methods for predictive glucose in accordance with embodiments of the invention are illustrated. One embodiment includes glucose management device, including a brain signal recorder, and a controller, including a processor, and a memory, the memory containing a glucose monitoring application configured to direct the processor to record a brain activity signal of a user's brain using the brain signal recorder, and decode the brain activity signal to predict future glucose levels of the patient.

Abstract: The disclosure is directed to compounds of the formula (IA), (I)-(V) and others disclosed herein and uses of such compounds.

Abstract: The disclosure provides an associative polymer, a powder, a process for forming a paper sheet, and a process for making a powder. One or more associative polymers and one or more optional surfactants may be networked to form a wet gel and a powder may be formed from the wet gel. The associative polymer may have a weight average molecular weight of from about 10 kDa to about 2,000 kDa. A method may involve adding the powder to a cellulose fiber slurry, draining the cellulose fiber slurry to form a fiber pad, and drying the fiber pad to form a paper sheet.

Abstract: A tape includes an electrically conductive adhesive first layer having opposite outermost first and second major surfaces. The first layer includes an electrically conductive porous medium and an adhesive disposed in, and extending through a thickness of, the porous medium to define at the first major surface, first regions of exposed adhesive and first regions of exposed porous medium and to define at the second major surface, second regions of exposed adhesive and second regions of exposed porous medium. The second major surface has a higher fraction of exposed porous medium than the first major surface. The porous medium can be a nonwoven fabric and the regions of exposed porous medium can be regions of exposed fibers.

Abstract: A method, apparatus, and system for creating a script for rendering audio and/or video streams include identifying at least one prosodic speech feature in a received audio stream and/or a received language model, creating a respective prosodic speech symbol for each of the at least one identified prosodic speech features, converting the received audio stream and/or the received language model into a text stream, temporally inserting the created at least one prosodic speech symbol into the text stream, identifying in a received video stream at least one prosodic gesture of at least a portion of a body of a speaker of the received audio stream, creating at least one respective gesture symbol for each of the at least one identified prosodic gestures, and temporally inserting the created at least one gesture symbol into the text stream along with the at least one prosodic speech symbol to create a prosodic script.

Abstract: Disclosed herein are playback devices, groups of playback devices, and methods of operating playback devices and groupings thereof to cause the playback devices in a mixed-mode configuration to play audio content in synchrony with each other.

Abstract: Formulations of 3-((3-(4-(2-(isobutylsulfonyl)phenoxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-5,5-dimethyl-1-(2-morpholinoethyl)imidazolidine-2,4-dione and pharmaceutically acceptable salts thereof, processes for their production, and uses thereof, including in the treatment of ocular diseases and disorders such as dry eye disease and Meibomian gland dysfunction (MGD).

Abstract: The present application is directed to methods and compositions for treating a condition marked by enhanced inflammation in the central nervous system (CNS). The methods comprise administering to a subject in need of treatment of enhanced inflammation in the CNS an inhibitor of an amino acid transporter in inflammatory cells present in the CNS. The compositions of the present invention relate to compositions comprising an inhibitor of an amino acid transporter in inflammatory cells, or a pharmaceutically acceptable salt thereof, wherein the composition is formulated for direct administration into the CNS of a mammal.

Abstract: A computer-implemented method for interacting with at least one data item obtained from at least one source utilizes computer processes responsive to a user selection of the at least one data item and include causing configuring of each of the data items into a distinct information object by extracting, from each data item, extracted data including a picture, a heading, and a link to the data item, and causing storing of data corresponding to each of the information objects in a database system. The processes further include displaying a representation of each of at least two of the information objects in the database system, the representation being in a uniform format, wherein the format includes a card, and, within the card, in uniform locations thereof, the picture, the heading, a set of indicators, and a set of graphically accessible functions.

Abstract: In one embodiment, a method includes receiving, from a client system of a first user of an online social network, a request for a user-list, generating a structured query corresponding to the user-list, where the structured query is selected from a plurality of structured queries, and identifying one or more second users of the online social network that match the structured query and have a social connection or non-social connection with the first user. The social connection between the first user and the second user being based on social interactions on the online social network. The non-social connection between the first user and the second user being based on non-social interactions on a third-party application on the client system and being accessed by the online social network from the third-party application. The method includes sending, to the client system, instructions for displaying the user-list to the first user.

Abstract: A computer-implemented method of interacting with at least one data item includes storing, in a database system, a configuration, of each of the data items as a distinct information object, in which each information object has an association with a picture, a heading, and a link to the corresponding data item. The method additionally uses the stored configurations to make available for display a representation of each of at least two of the information objects in a uniform format, wherein the format includes a card, and, within the card, the picture, the heading, a set of indicators, the set of indicators having at least one member, and a function mechanism giving graphical access to a set of functions.

Abstract: In one embodiment, a method includes identifying one or more first users of a social-networking system associated with one or more content objects not previously viewed by a second user. The identification is based at least in part on an affinity of the second user for the first users and the first users are connected to the second user on a social graph. The method also includes providing, for display on a client device of the second user, information indicating that one or more of the identified first users has content objects not previously viewed by the second user; receiving an input selecting one of the identified first users; and providing, for display on the client device, an online page comprising content associated with the selected first user that incorporates one or more of the content objects not previously viewed by the second user.

Abstract: A computer-implemented method for interacting with at least one data item obtained from at least one source utilizes computer processes responsive to a user selection of the at least one data item and include causing configuring of each of the data items into a distinct information object by extracting, from each data item, extracted data including a picture, a heading, and a link to the data item, and causing storing of data corresponding to each of the information objects in a database system. The processes further include displaying a representation of each of at least two of the information objects in the database system, the representation being in a uniform format, wherein the format includes a card, and, within the card, in uniform locations thereof, the picture, the heading, a set of indicators, and a set of graphically accessible functions.

Abstract: In one embodiment, a method includes receiving, from a client system associated with a first user, a request to access a user-card interface. The method includes generating, in response to the request, multiple user-cards, each user-card being associated with a pre-selected query. Each user-card includes references to second users matching the pre-selected query associated with the user-card. The method includes calculating a user-card score for each user-card. The user-card score represents a relevance of the pre-selected query to the first user and a relevance of the second users referenced in the user-card to the first user. The relevance of each second user referenced in the user-card is based on an affinity coefficient of the first user with respect to the second user. The method includes sending, to the client system, instructions for presenting the user-card interface with user-cards in ranked order based on the user-card score associated with each user-card.

Abstract: In one embodiment, one or more computer systems of a social-networking system receive an input video associated with a first user of an online social networking system. The computer systems receive, from a client system of a second user of the online social networking system, a request to view content associated with the first user. The computer systems generate one or more output videos based on the input video, the one or more output videos are generated by applying a predefined video template, and the predefined video template includes a plurality of video settings and transcodes the input video to the one or more output videos. The computer systems select one of the one or more output videos, the selected output video comprises at least a portion of the input video. The computer systems provide, for display on the client system, the selected output video together with the requested content.

Abstract: In one embodiment, a method includes receiving, from a client system of a first user of an online social network, a request for a user-list, generating a structured query corresponding to the user-list, where the structured query is selected from a plurality of structured queries, and identifying one or more second users of the online social network that match the structured query and have a social connection or non-social connection with the first user. The social connection between the first user and the second user being based on social interactions on the online social network. The non-social connection between the first user and the second user being based on non-social interactions on a third-party application on the client system and being accessed by the online social network from the third-party application. The method includes sending, to the client system, instructions for displaying the user-list to the first user.

Abstract: A privacy-controlled care requester communication system includes a care-requester onsite monitoring and communication device and a cloud-computing server accommodating on-demand caregiver conferencing and vital stat alert capabilities. The care-requester onsite monitoring and communication device provides a closed-circuit visual and audio monitoring of the care requester's vicinity with specialized privacy permission rules that are set and adjusted by the care requester to achieve a personally-comfortable balance between health/safety risk monitoring and privacy considerations for a grownup patient. The care-requester onsite monitoring and communication device also enables either the care requester or the caregiving entity to initiate a “welfare check” webcam conferencing using the same care-requester onsite monitoring and communication device.

Abstract: In one embodiment, a method includes receiving an input corresponding to a search query from an online page of a social-networking system. The online page corresponds to a target user of the social-networking system. The method also includes identifying one or more of a number of content objects associated with the target user. The association is based at least in part on analyzing text, audio, or visual content of each of the plurality of content objects as well as interactions by the target user with each of the plurality of content objects. The method also includes scoring each of the identified content objects based at least in part on an affinity score of the content object relative to a querying user; and ranking each of the identified content objects based at least in part on the affinity score.

Abstract: A privacy-controlled care requester communication system includes a care-requester onsite monitoring and communication device and a cloud-computing server accommodating on-demand caregiver conferencing and vital stat alert capabilities. The care-requester onsite monitoring and communication device provides a closed-circuit visual and audio monitoring of the care requester's vicinity with specialized privacy permission rules that are set and adjusted by the care requester to achieve a personally-comfortable balance between health/safety risk monitoring and privacy considerations for a grownup patient. The care-requester onsite monitoring and communication device also enables either the care requester or the caregiving entity to initiate a “welfare check” webcam conferencing using the same care-requester onsite monitoring and communication device.