Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: A graft preparation system includes a fixation implant including a strand of suture wrapped around a graft preparation card. A tenaculum includes a first arm having a first tooth and a second arm having a second tooth that are pivotally connected at a pivot. The first arm includes a slot between the first tooth and the pivot that receives the graft preparation card. A tape suture assembly includes a tape suture and a first suture strand. The tape suture is positioned on a graft, and the tape suture is attached to the graft with a stitch formed with the first suture strand.

Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: A graft preparation system includes a fixation implant including a strand of suture wrapped around a graft preparation card. A tenaculum includes a first arm having a first tooth and a second arm having a second tooth that are pivotally connected at a pivot. The first arm includes a slot between the first tooth and the pivot that receives the graft preparation card. A tape suture assembly includes a tape suture and a first suture strand. The tape suture is positioned on a graft, and the tape suture is attached to the graft with a stitch formed with the first suture strand.

Abstract: Provided are methods for clinical treatment of malignant tumors (e.g., advanced solid tumors) using a combination of an anti-LAG-3 antibody, an anti-PD-1 antibody, and an immunotherapeutic agent.

Abstract: A mechanism is described for facilitating smart distribution of resources for deep learning autonomous machines. A method of embodiments, as described herein, includes detecting one or more sets of data from one or more sources over one or more networks, and introducing a library to a neural network application to determine optimal point at which to apply frequency scaling without degrading performance of the neural network application at a computing device.

Abstract: A graft preparation system includes a fixation implant including a strand of suture wrapped around a graft preparation card. A tenaculum includes a first arm having a first tooth and a second arm having a second tooth that are pivotally connected at a pivot. The first arm includes a slot between the first tooth and the pivot that receives the graft preparation card. A tape suture assembly includes a tape suture and a first suture strand. The tape suture is positioned on a graft, and the tape suture is attached to the graft with a stitch formed with the first suture strand.

Abstract: A mechanism is described for facilitating smart distribution of resources for deep learning autonomous machines. A method of embodiments, as described herein, includes detecting one or more sets of data from one or more sources over one or more networks, and introducing a library to a neural network application to determine optimal point at which to apply frequency scaling without degrading performance of the neural network application at a computing device.

Abstract: Provided are methods for clinical treatment of malignant tumors (e.g., advanced solid tumors) using a combination of an anti-LAG-3 antibody, an anti-PD-1 antibody, and an immunotherapeutic agent.

Abstract: A communication network authenticates the source of messages transmitted on a flat bus to determine the presence of spoofing events. A programmable intrusion detection device is connected to the bus at a fixed location and compiles templates for various tri-bit signal pulses that form the data transmitted as messages between network nodes. Each tri-bit template compares unique signal characteristics inherent in the signal waveform received by the device from each node, the unique characteristics being directly attributable to the physical topology of the network. In use, the device uses the templates to calculate an inferred source identifier for each message. The inferred source identifier is then compared against the declared source identifier, which is embedded in message metadata, to authenticate the message source. Any lack of reconciliation between the inferred and declared source identifiers causes the device to mark the message as spoofed and initiate a designated response.

Abstract: A flat and detachable electrical connection system between a flat lighting module and a lampholder is described. The flat lighting module comprises a lighting panel, control circuitry for controlling the lighting panel, and electrical contact pads connected to the control circuitry, all supported at least in part by a mechanical support plate; the mechanical support plate being at least partially enclosed in a housing with a provision or opening so that light can be emitted from the lighting panel; and where the mechanical support plate includes a male mechanical support connector section that extends out from the mechanical support plate in the same plane as the thickness of the lighting module; and where the male mechanical support connector section includes means for non-permanent locking or latching of the lighting module to the lampholder.

Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-Ll positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: A graft preparation system includes a fixation implant including a strand of suture wrapped around a graft preparation card. A tenaculum includes a first arm having a first tooth and a second arm having a second tooth that are pivotally connected at a pivot. The first arm includes a slot between the first tooth and the pivot that receives the graft preparation card. A tape suture assembly includes a tape suture and a first suture strand. The tape suture is positioned on a graft, and the tape suture is attached to the graft with a stitch formed with the first suture strand.

Abstract: An apparatus for preparing a personal smokable product includes: a grinder section comprising a grinder for grinding plant material; a holder section attachable to the grinder section and comprising a holder receiving a wrapper support for supporting a wrapper for receiving ground plant material when aligned with the grinder; and one or more removably attachable auxiliary modules, which may include a dry herb vaporizer, an oil vaporizer, an audio speaker, and/or a storage compartment. The grinder includes a cutter having wall blades projecting from a chamber-defining wall toward a central axis of the chamber; a motor-driven shaft rotatable about the central axis, and shaft blades projecting radially from the shaft. The grinder includes conical bun members with an adjustable gap for coarseness. Even when the grinder section and the holder section are attached to each other, the wrapper is user-accessible if the holder is in its non-aligned position.

Abstract: A stabilizer system includes a first object that moves relative to a second object and includes a first actuator coupled to a first wear pad. The first actuator drives the first wear pad to contact a first side of the second object to control motion of the first object relative to the second object. The first actuator operates in a first mode and in a second mode. While operating in the first mode, the first actuator applies a first force to the first wear pad to block the motion of first object relative to the second object. While the first actuator is operating in the second mode, the first actuator applies a second force, lower than the first force, to the first wear pad to enable the motion of the first object relative to the second object.

Abstract: A flat and detachable electrical connection system between a flat lighting module and a lampholder is described. The flat lighting module comprises a lighting panel, control circuitry for controlling the lighting panel, and electrical contact pads connected to the control circuitry, all supported at least in part by a mechanical support plate; the mechanical support plate being at least partially enclosed in a housing with a provision or opening so that light can be emitted from the lighting panel; and where the mechanical support plate includes a male mechanical support connector section that extends out from the mechanical support plate in the same plane as the thickness of the lighting module; and where the male mechanical support connector section includes means for non-permanent locking or latching of the lighting module to the lampholder.

Abstract: A stabilizer system includes a first object that moves relative to a second object and includes a first actuator coupled to a first wear pad. The first actuator drives the first wear pad to contact a first side of the second object to control motion of the first object relative to the second object. The first actuator operates in a first mode and in a second mode. While operating in the first mode, the first actuator applies a first force to the first wear pad to block the motion of first object relative to the second object. While the first actuator is operating in the second mode, the first actuator applies a second force, lower than the first force, to the first wear pad to enable the motion of the first object relative to the second object.

Abstract: A visual content display system and a method are provided for displaying visually informative content remotely received over a network. The visual content display system includes a display device, database, server, and controller. The display device displays visual content. The display device includes a wireless transceiver and universal mounting hardware. The wireless transceiver establishes a communication with a network to display the visual content received from electronic devices operably connected over the network. The universal mounting hardware secures the display device to objects. The database stores data pertaining to the visual content. The server provides information pertaining to the visual content in response to a request received from a user over the network. The controller provides the data pertaining to the visual content to the server from the database. The server provides the visual content information to be displayed through the display device over the network.

Abstract: The present disclosure is directed to a braking system for a work vehicle having hydraulically-actuated brakes. The braking system includes a primary release valve, a secondary release valve, and at least one braking mechanism having one or more brake springs. The braking mechanism(s) is hydraulically coupled to the primary release valve and the secondary release valve via one or more hydraulic lines. As such, during full-power operation of the work vehicle, when the brakes are to be released, the primary release valve is energized so as to overcome a valve biasing spring, thereby shifting the primary release valve so as to direct pressurized hydraulic fluid to the braking mechanism(s). Further, when the brakes are to be applied, the primary release valve is inactive so as to allow the hydraulic fluid to flow away from the braking mechanism(s) to a primary reservoir such that the one or more brake springs compress the braking mechanism(s).

Abstract: This disclosure relates to surgical fixation systems and methods. The surgical fixation systems can include a fixation device and an adjustable loop connected to the fixation device. A reinforcement construct may be integrated with the adjustable loop.