Patents by Inventor Jeffrey James Rade

Jeffrey James Rade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Augmentation of endothelial thromboresistance
    Patent number: 8454952
    Abstract: Stretch-induced increased hemodynamic load adversely affects endothelial cell function and is an important contributor to thromboembolus formation in heart failure, valvular heart disease, atrial fibrillation, venous insufficiency, and pulmonary hypertension, and in thrombus occluded vein grafts. Local thrombus formation and thromboenbolic events can be reduced by inhibiting the TGF-beta signaling pathway or TGF-beta per se. Inhibitors can be administered to patients or veins (prior to interposition) at risk for thromboembolic events or local thrombus formation. Inhibitors can be applied to harvested veins to be used as arterial grafts.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: June 4, 2013
    Assignee: The Johns Hopkins University
    Inventors: Jeffrey James Rade, Navin Kumar Kapur
  • AUGMENTATION OF ENDOTHELIAL THROMBORESISTANCE
    Publication number: 20090186016
    Abstract: Stretch-induced increased hemodynamic load adversely affects endothelial cell function and is an important contributor to thromboembolus formation in heart failure, valvular heart disease, atrial fibrillation, venous insufficiency, and pulmonary hypertension, and in thrombus occluded vein grafts. Local thrombus formation and thromboenbolic events can be reduced by inhibiting the TGF-beta signaling pathway or TGF-beta per se. Inhibitors can be administered to patients or veins (prior to interposition) at risk for thromboembolic events or local thrombus formation. Inhibitors can be applied to harvested veins to be used as arterial grafts.
    Type: Application
    Filed: March 13, 2007
    Publication date: July 23, 2009
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jeffrey James Rade, Navin Kumar Kapur