Patents by Inventor Jeffrey Jeddeloh

Jeffrey Jeddeloh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENRICHMENT AND SEQUENCE ANALYSIS OF GENOMIC REGIONS
    Publication number: 20080194414
    Abstract: The present invention provides novel methods for reducing the complexity of preferably a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented (genomic) nucleic acids for reducing the genetic complexity of the original population of nucleic acid molecules.
    Type: Application
    Filed: January 8, 2008
    Publication date: August 14, 2008
    Inventors: Thomas J. Albert, Roland Green, Todd Richmond, Michael Molla, Jeffrey Jeddeloh, Jason Patrick Affourtit, Mathreyan Srinivasan, Brian Christopher Godwin, Matthew Rodesch
  • Gene methylation in cancer diagnosis
    Publication number: 20070298506
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use in detecting and diagnosing cancer.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 27, 2007
    Applicant: Orion Genomics LLC
    Inventors: Jared Ordway, Jeffrey Jeddeloh, Joseph Bedell
  • Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets
    Publication number: 20070224626
    Abstract: The present invention provides DNA marker sequences that are differentially methylated in samples from normal individuals and individuals with brain cancer. The invention further provides methods of identifying differentially methylated DNA marker sequences and their use the detection and diagnosis of gliomas.
    Type: Application
    Filed: March 8, 2007
    Publication date: September 27, 2007
    Applicant: Orion Genomics LLC
    Inventors: Jeffrey Jeddeloh, Jared Ordway
  • Differential enzymatic fragmentation by whole genome amplification
    Publication number: 20050272065
    Abstract: The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
    Type: Application
    Filed: March 2, 2005
    Publication date: December 8, 2005
    Applicant: Orion Genomics LLC
    Inventors: Nathan Lakey, Jeffrey Jeddeloh, Yulia Korshunova
  • Differential enzymatic fragmentation
    Publication number: 20050158739
    Abstract: The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
    Type: Application
    Filed: October 21, 2004
    Publication date: July 21, 2005
    Inventors: Jeffrey Jeddeloh, Nathan Lakey
  • Methods for quantitative determination of methylation density in a DNA locus
    Publication number: 20050153316
    Abstract: The present invention is a novel method of determining the average DNA methylation density of a locus of interest within a population of DNA fragments.
    Type: Application
    Filed: October 21, 2004
    Publication date: July 14, 2005
    Applicant: Orion Genomics LLC
    Inventors: Jeffrey Jeddeloh, Nathan Lakey
  • Glanders/meliodosis vaccines
    Publication number: 20040171020
    Abstract: The present invention relates to nucleic acids encoding B. mallei and B. pseudomallei AHL synthases and LuxR transcriptional regulators, and methods for use, as well as describes the construction, characterization and use of avirulent strains of B. mallei and methods of use.
    Type: Application
    Filed: July 15, 2003
    Publication date: September 2, 2004
    Inventors: Ricky Ulrich, Jeffrey Jeddeloh, Petra Oyston
  • DNA methylation gene from plants
    Patent number: 6153741
    Abstract: A novel gene, DDM1, and its encoded protein are provided. The gene was isolated from a region of Arabidopsis thaliana chromosome 5. DDM1 appears to be part of the SWI2/SNF2 family of chromatin-remodeling proteins. Disruption of the gene results in DNA hypomethylation, among other phenotypes. The DDM1 gene defines a novel member of the DNA methylation system. Methods of using DDM1, and transgenic organisms comprising DDM1, are also provided.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: November 28, 2000
    Assignee: Washington University
    Inventors: Eric J. Richards, Jeffrey A. Jeddeloh