Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: An improved pump device and control system for removal of liquid, such as viscous leachate, from a bore. A pump device includes a casing with an inlet check valve on a lower portion thereof and a discharge check valve on an upper portion thereof positioned within the casing. A fill cavity within the casing is connectable to a source of pressurized gas. As liquid/viscous leachate accumulates within the bore it enters the fill cavity through the inlet check valve. As pressurized gas is introduced to the fill cavity it displaces liquid/leachate from the fill cavity into and through a discharge tube and upward through the discharge check valve to remove the liquid/leachate from the fill cavity. The pump does not comprise a float. Control systems and devices provide for improved automated, semi-automated, and manual monitoring and control of pump device operation.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: A support product configured to receive poured concrete, the support product comprising a latticework of walls and a plurality of edges, wherein the walls extend between a lower surface and an upper surface and define a plurality of cells, wherein at least one edge comprises a catch and a partial keyway, wherein the catch is configured to connect with a catch of an adjacent support product to restrain relative movement of connected support products, and wherein the partial keyway is configured to be located adjacent to a partial keyway of a connected support product, so that adjacent partial keyways define a complete keyway between connected support products.

Abstract: An apparatus including an assembly associated with a downhole tool configured to thermally isolate a thermally sensitive component. Components of the assembly include an external isolating vessel; a passive thermal barrier encased in the external isolating vessel; at least one electronic component housed within the downhole tool for monitoring geothermal well properties; and at least one thermally sensitive electronics carrier package positioned within the passive thermal barrier comprising thermally sensitive electronic components. The passive thermal barrier ideally comprises an additively manufactured layered labyrinthine shell structure, a plurality of polarly phased centralizers between shell layers and minimal centralizing contact points on its exterior shell, to minimize known heat transfer modes associated with the external isolating vessel.

Abstract: A downhole actuator device is provided for use in directing wellbore fluid to be used in performing work in a wellbore by convening a pressure source into a force exerted over a distance. The core components of the downhole actuator device include a pressure chamber containing an insertable activation module, an insertable pressure source module capable of generating a pressure or force and a pressure responsive member. The core components of the pressure source module can include one or more of a plurality of optional formats for delivery of the force comprising a solenoid and a mechanical trigger, a non-explosive pyrotechnic device insert, or a charged gas module insert, which, when appropriately combined, sequenced and activated, will open a pressure responsive member that will allow wellbore fluid, at hydrostatic pressure, to enter the tool thereby providing the energy needed to actuate various mechanical and/or hydraulic components downhole.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: The present invention provides, inter alia, methods and kits for identifying where a polypeptide of interest binds in a genome. The methods include a) carrying out a chromatin immunoprecipitation coupled to exonuclease digestion (ChIP-exo) process with an antibody against the polypeptide of interest; (b) extracting a polynucleotide fragment to which the polypeptide of interest binds; (c) carrying out a library preparation protocol adapted from an individual nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP) process on the ChIP-exo processed polynucleotide fragment; and (d) sequencing the resulting polynucleotides. The kits include: (a) reagents sufficient to carry out ChIP-exo; (b) reagents sufficient to carry out the library preparation protocol adapted from the iCLIP process; and (c) instructions for use.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: Deployment apparatus (10) including a deployment object (12), a deployment arm (16) with a first end (22) coupled to the deployment object and a second end (24) having a pivot (26), and a hinge assembly (18) rotatably attached to the pivot of the deployment arm. The hinge assembly (18) includes an enclosure (44) and a friction stop device (82) disposed within the enclosure such that the friction stop device includes a friction portion (80) configured to be pressed against a lateral surface of the pivot (26) of the deployment arm such that the friction portion provides a predetermined torque. The predetermined torque may be calculated based on maintaining a deployed angle of the deployment arm (16) such that the deployment object (12) is held in a raised deployed position.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: Deployment apparatus (10) including a deployment object (12), a deployment arm (16) with a first end (22) coupled to the deployment object and a second end (24) having a pivot (26), and a hinge assembly (18) rotatably attached to the pivot of the deployment arm. The hinge assembly (18) includes an enclosure (44) and a friction stop device (82) disposed within the enclosure such that the friction stop device includes a friction portion (80) configured to be pressed against a lateral surface of the pivot (26) of the deployment arm such that the friction portion provides a predetermined torque. The predetermined torque may be calculated based on maintaining a deployed angle of the deployment arm (16) such that the deployment object (12) is held in a raised deployed position.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide.

Abstract: A method of modulating the pharmacodynamic effect of a GC-C receptor agonist polypeptide formulation in a subject in need of such treatment is disclosed, The method comprises administering the GC-C receptor agonist polypeptide formulation to the subject before the ingestion of food.

Abstract: In general, in one aspect, the invention features methods that include using an interferometer to produce an output beam having a phase related to an optical path difference between a path of a first beam and a path of a second beam, wherein the first beam contacts a measurement object and either the measurement object or the interferometer are coupled (e.g., directly attached) to a stage that is moveable within a reference frame. The methods further include monitoring variations in the phase while both varying an orientation of the stage with respect to at least one degree of freedom in the reference frame and keeping a reference mark on the stage in a common position with respect to the reference frame, and determining information based on the monitored variations, the information being related to a contribution to the optical path difference caused by a deviation of the path of the first or second beam from a nominal beam path.