Abstract: Integrated substrate processing systems are disclosed that are able to achieve high-volume processing of substrates (e.g., greater than 120 substrates per hour) using environmentally sensitive processes and/or tools, such as photolithography processes and/or tools. In some embodiments, for example, the integrated substrate processing system may include an EFEM and a processing tool enclosure that are coupled together to form an integrated processing environment. The integrated substrate processing system may operate to maintain substantially uniform conditions (e.g., at a uniform temperature and relative humidity) throughout the integrated environment, and in some embodiments, may utilize an external air source, such as a remote air module (RAM), in order to do so. In some embodiments, high-volume processing of substrates may be further facilitated by employing specialized substrate handling robots and/or specially adapting the EFEM and/or processing tool enclosure.

Abstract: An improved pipeline leak detecting pig apparatus configured to locate leaks in the wall of a pipeline as the apparatus is pushed by pressurized fluid through the pipeline. The apparatus is configured with or without absolute pressure sensors and a flow meter configured to detect fluid flow through a controlled volume on the pig passing a leak in the pipeline and pressurized fluid in the controlled volume escapes through the leak. Pressure sensors, when provided, provide a secondary confirmation of the presence of a leak and the degree of severity when an absolute pressure drop in the controlled volume occurs. Onboard microcontrollers record continuous odometer pulses, apparatus diagnostic information and pressure and flow measurements for later analysis, quantification and determination of leak location.

Abstract: An improved pipeline leak detecting pig apparatus configured to locate leaks in the wall of a pipeline as the apparatus is pushed by pressurized fluid through the pipeline. The apparatus is configured with or without absolute pressure sensors and a flow meter configured to detect fluid flow through a controlled volume on the pig passing a leak in the pipeline and pressurized fluid in the controlled volume escapes through the leak. Pressure sensors, when provided, provide a secondary confirmation of the presence of a leak and the degree of severity when an absolute pressure drop in the controlled volume occurs. Onboard microcontrollers record continuous odometer pulses, apparatus diagnostic information and pressure and flow measurements for later analysis, quantification and determination of leak location.

Abstract: An apparatus including an assembly associated with a downhole tool configured to thermally isolate a thermally sensitive component. Components of the assembly include an external isolating vessel; a passive thermal barrier encased in the external isolating vessel; at least one electronic component housed within the downhole tool for monitoring geothermal well properties; and at least one thermally sensitive electronics carrier package positioned within the passive thermal barrier comprising thermally sensitive electronic components. The passive thermal barrier ideally comprises an additively manufactured layered labyrinthine shell structure, a plurality of polarly phased centralizers between shell layers and minimal centralizing contact points on its exterior shell, to minimize known heat transfer modes associated with the external isolating vessel.

Abstract: A downhole actuator device is provided for use in directing wellbore fluid to be used in performing work in a wellbore by convening a pressure source into a force exerted over a distance. The core components of the downhole actuator device include a pressure chamber containing an insertable activation module, an insertable pressure source module capable of generating a pressure or force and a pressure responsive member. The core components of the pressure source module can include one or more of a plurality of optional formats for delivery of the force comprising a solenoid and a mechanical trigger, a non-explosive pyrotechnic device insert, or a charged gas module insert, which, when appropriately combined, sequenced and activated, will open a pressure responsive member that will allow wellbore fluid, at hydrostatic pressure, to enter the tool thereby providing the energy needed to actuate various mechanical and/or hydraulic components downhole.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: An improved pump device and control system for removal of liquid, such as viscous leachate, from a bore. A pump device includes a casing with an inlet check valve on a lower portion thereof and a discharge check valve on an upper portion thereof positioned within the casing. A fill cavity within the casing is connectable to a source of pressurized gas. As liquid/viscous leachate accumulates within the bore it enters the fill cavity through the inlet check valve. As pressurized gas is introduced to the fill cavity it displaces liquid/leachate from the fill cavity into and through a discharge tube and upward through the discharge check valve to remove the liquid/leachate from the fill cavity. The pump does not comprise a float. Control systems and devices provide for improved automated, semi-automated, and manual monitoring and control of pump device operation.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: A support product configured to receive poured concrete, the support product comprising a latticework of walls and a plurality of edges, wherein the walls extend between a lower surface and an upper surface and define a plurality of cells, wherein at least one edge comprises a catch and a partial keyway, wherein the catch is configured to connect with a catch of an adjacent support product to restrain relative movement of connected support products, and wherein the partial keyway is configured to be located adjacent to a partial keyway of a connected support product, so that adjacent partial keyways define a complete keyway between connected support products.

Abstract: An apparatus including an assembly associated with a downhole tool configured to thermally isolate a thermally sensitive component. Components of the assembly include an external isolating vessel; a passive thermal barrier encased in the external isolating vessel; at least one electronic component housed within the downhole tool for monitoring geothermal well properties; and at least one thermally sensitive electronics carrier package positioned within the passive thermal barrier comprising thermally sensitive electronic components. The passive thermal barrier ideally comprises an additively manufactured layered labyrinthine shell structure, a plurality of polarly phased centralizers between shell layers and minimal centralizing contact points on its exterior shell, to minimize known heat transfer modes associated with the external isolating vessel.

Abstract: A downhole actuator device is provided for use in directing wellbore fluid to be used in performing work in a wellbore by convening a pressure source into a force exerted over a distance. The core components of the downhole actuator device include a pressure chamber containing an insertable activation module, an insertable pressure source module capable of generating a pressure or force and a pressure responsive member. The core components of the pressure source module can include one or more of a plurality of optional formats for delivery of the force comprising a solenoid and a mechanical trigger, a non-explosive pyrotechnic device insert, or a charged gas module insert, which, when appropriately combined, sequenced and activated, will open a pressure responsive member that will allow wellbore fluid, at hydrostatic pressure, to enter the tool thereby providing the energy needed to actuate various mechanical and/or hydraulic components downhole.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: The present invention provides, inter alia, methods and kits for identifying where a polypeptide of interest binds in a genome. The methods include a) carrying out a chromatin immunoprecipitation coupled to exonuclease digestion (ChIP-exo) process with an antibody against the polypeptide of interest; (b) extracting a polynucleotide fragment to which the polypeptide of interest binds; (c) carrying out a library preparation protocol adapted from an individual nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP) process on the ChIP-exo processed polynucleotide fragment; and (d) sequencing the resulting polynucleotides. The kits include: (a) reagents sufficient to carry out ChIP-exo; (b) reagents sufficient to carry out the library preparation protocol adapted from the iCLIP process; and (c) instructions for use.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: Deployment apparatus (10) including a deployment object (12), a deployment arm (16) with a first end (22) coupled to the deployment object and a second end (24) having a pivot (26), and a hinge assembly (18) rotatably attached to the pivot of the deployment arm. The hinge assembly (18) includes an enclosure (44) and a friction stop device (82) disposed within the enclosure such that the friction stop device includes a friction portion (80) configured to be pressed against a lateral surface of the pivot (26) of the deployment arm such that the friction portion provides a predetermined torque. The predetermined torque may be calculated based on maintaining a deployed angle of the deployment arm (16) such that the deployment object (12) is held in a raised deployed position.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.

Abstract: Deployment apparatus (10) including a deployment object (12), a deployment arm (16) with a first end (22) coupled to the deployment object and a second end (24) having a pivot (26), and a hinge assembly (18) rotatably attached to the pivot of the deployment arm. The hinge assembly (18) includes an enclosure (44) and a friction stop device (82) disposed within the enclosure such that the friction stop device includes a friction portion (80) configured to be pressed against a lateral surface of the pivot (26) of the deployment arm such that the friction portion provides a predetermined torque. The predetermined torque may be calculated based on maintaining a deployed angle of the deployment arm (16) such that the deployment object (12) is held in a raised deployed position.

Abstract: The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.