Abstract: The present disclosure provides bifunctional compounds of Formula (I), and pharmaceutically acceptable salts, isotopic forms, isolated stereoisomers, or mixtures of stereoisomers thereof, as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: Methods and systems for providing vehicular safety control are described herein. In some embodiments, a system of vehicular safety control can help reduce or avoid human, animal, property, monetary, time and/or energy losses. The system comprises or uses sensors to perceive driving environments, and analyses of guidance commands and sensor data can evaluate potential risks.

Abstract: An air-over evaporative heat exchanger with multi-lobed or “peanut” shaped tubes replacing conventional round or elliptical tubes. The tubes have a narrow horizontal cross section and tall vertical cross section to allow the multiplication of surface area in the same coil volume while maintaining or increasing the open-air passage area. This configuration allows the coil to have an overall external heat transfer coefficient much higher than a conventional coil, while the tube shape allows the use of thinner material, reducing the weight and cost of the heat exchanger.

Abstract: An air-over evaporative heat exchanger with multi-lobed or “peanut” shaped tubes replacing conventional round or elliptical tubes. The tubes have a narrow horizontal cross section and tall vertical cross section to allow the multiplication of surface area in the same coil volume while maintaining or increasing the open-air passage area. This configuration allows the coil to have an overall external heat transfer coefficient much higher than a conventional coil, while the tube shape allows the use of thinner material, reducing the weight and cost of the heat exchanger.

Abstract: An air-over evaporative heat exchanger with multi-lobed or “peanut” shaped tubes replacing conventional round or elliptical tubes. The tubes have a narrow horizontal cross section and tall vertical cross section to allow the multiplication of surface area in the same coil volume while maintaining or increasing the open-air passage area. This configuration allows the coil to have an overall external heat transfer coefficient much higher than a conventional coil, while the tube shape allows the use of thinner material, reducing the weight and cost of the heat exchanger.

Abstract: An air-over evaporative heat exchanger with multi-lobed or “peanut” shaped tubes replacing conventional round or elliptical tubes. The tubes have a narrow horizontal cross section and tall vertical cross section to allow the multiplication of surface area in the same coil volume while maintaining or increasing the open-air passage area. This configuration allows the coil to have an overall external heat transfer coefficient much higher than a conventional coil, while the tube shape allows the use of thinner material, reducing the weight and cost of the heat exchanger.

Abstract: A composite sheet includes a base sheet comprising a single ply of dried stock material that includes non-woven natural fibers or non-woven synthetic fibers or both, with the base sheet having a top surface, a bottom surface, and a base sheet thickness between the top surface and the bottom surface. The composite sheet also includes a scrim formed from a plurality of intersecting strands, with the thickness of the scrim, as defined at the intersections of the strands, being at least one third the base sheet thickness, and with at least a majority portion of the thickness of the mesh layer being embedded within the thickness of the base sheet to provide reinforcement for the base sheet.

Abstract: A sample container and filtration apparatus includes a sample container portion with an interior volume and a fluid path passing through a bottom wall. The sample container may also include a valve casing connected to and moveable relative to the sample collection portion between a first and second position. A valve secured to and moveable with the valve casing may close the fluid path of the sample collection portion when in a first position and open the fluid path when in a second position. The apparatus may also include a vacuum base coupling portion that is distal to the valve casing, and includes a filter membrane support surface for supporting a filter membrane.

Abstract: A sample container and filtration apparatus is described comprising a sealable sample container and a surface that is configured to interface with a vacuum base. When the surface interfaces with the vacuum base, a portion of the sample container is broached, providing a pathway for the vacuum source to pull the sample therethrough. In exemplary embodiments, the broachable portion of the sample container comprises an actuating valve. The method for using the sample container and filtration apparatus significantly reduces the possibility of contamination of the sample and during the sample testing procedure relative to the conventional devices and procedures, provides more consistent and reliable test results, and significantly reduces the number of preparation and testing steps for the testing procedure.

Abstract: A well (50) comprising a side wall (10), a sealing ring (40), a rib arrangement (5), and a filter (20), for use in processing a fluid, e.g., by microtitration or microfiltration, is disclosed.

Abstract: A medical valve transitions between an open mode that permits fluid flow, and a closed mode that prevents fluid flow. To that end, the valve has a housing with an inlet and an outlet, and a movable member with a member channel therethrough. The movable member is movable to cause the valve to transition from the closed mode to the open mode after insertion of a medical implement into the inlet. The member channel fluidly communicates the inlet and the outlet when in the open mode. The valve also has a resilient member with a member flow path in fluid communication with the outlet. The movable member slides along the resilient member when transitioning between the open mode and the closed mode. The resilient member normally has a flange (about the member flow path) that is compressed by the movable member. The flange fluidly disconnects the member flow path from the member channel when in the closed mode.

Abstract: A medical valve has an open mode that permits fluid flow, and a closed mode that prevents fluid flow. To that end, the medical valve has a housing with an inlet portion and an outlet portion, a rotating member having a protruding member, and a resilient member with a complimentary surface that mates with the protruding member. The inlet portion and outlet portion of the housing compress the protruding member into the resilient member to bias the valve to the closed mode.

Abstract: A medical valve has an open mode that permits fluid flow, and a closed mode that prevents fluid flow. To that end, the medical valve has a housing with an inlet and an outlet, and a movable member with a member channel therethrough. The member channel extends between a proximal opening and a distal opening of the movable member. The movable member is movable in a given direction to cause the valve to transition from the closed mode to the open mode. The distal opening of the member channel has a given dimension that is generally parallel with the given direction, and a second dimension that is generally orthogonal to the given dimension. The given dimension is smaller than the second dimension.

Abstract: A medical valve transitions between an open mode that permits fluid flow, and a closed mode that prevents fluid flow. To that end, the valve has a housing with an inlet and an outlet, and a rotating member with a member channel. The rotating member is rotatable to cause the valve to transition from the closed mode to the open mode after insertion of a medical implement into the inlet. The member channel fluidly communicates the inlet and the outlet when in the open mode. The medical valve also has a resilient member biasing the rotating member toward the closed mode. The rotating member slides along the resilient member when rotating between the open mode and closed mode.

Abstract: A medical valve has an open mode that permits fluid flow, and a closed mode that prevents fluid flow. The valve has a housing having an inlet and an outlet, and a valving mechanism within the housing to alternatively fluidly connect the inlet and the outlet. The valve is in the open mode when the inlet and outlet fluidly connect. Insertion of a medical implement into the inlet produces a positive fluid displacement at the outlet. In addition, withdrawal of the medical implement as the valve transitions from the open mode to the closed mode produces a substantially neutral fluid displacement at the outlet.

Abstract: A well (50) comprising a side wall (10), a sealing ring (40), a rib arrangement (5), and a filter (20), for use in processing a fluid, e.g., by microtitration or microfiltration, is disclosed.

Abstract: A well (50) comprising a side wall (10), a sealing ring (40), a rib arrangement (5), and a filter (20), for use in processing a fluid, e.g., by microtitration or microfiltration, is disclosed.

Abstract: An analysis device comprising a microporous membrane integrally bonded to a non-porous polymeric injection-molded support is disclosed. Methods for making and using the analysis device are also provided.

Abstract: A well (50) comprising a side wall (10), a sealing ring (40), a rib arrangement (5), and a filter (20), for use in processing a fluid, e.g., by microtitration or microfiltration, is disclosed.

Abstract: A filtration assembly (10) for use in collecting a fluid sample possibly containing microorganisms, and capturing the microorganisms of interest in the sample such that the captured microorganisms can be subsequently detected. The filtration assembly includes a sample reservoir (20) for collecting and holding the fluid sample to be filtered, a fluid port (38) and a vent (70) in communication with the sample reservoir, a filter element (45) disposed in a flow path between the sample reservoir and fluid port, and a cover member (50) detachably covering the sample reservoir.