Patents by Inventor Jeffrey L. Ardell

Jeffrey L. Ardell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction
    Patent number: 11738199
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: August 29, 2023
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
  • RESPONSIVE NEUROSTIMULATION FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION
    Publication number: 20220226657
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
    Type: Application
    Filed: April 8, 2022
    Publication date: July 21, 2022
    Applicants: LivaNova USA, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
  • Responsive neurostimulation for the treatment of chronic cardiac dysfunction
    Patent number: 11298543
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: April 12, 2022
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
  • Monitoring and modulation of parasympathetic nervous system
    Patent number: 11241579
    Abstract: The present invention provides systems and methods for monitoring cardiac autonomic nervous system activity and modulating parasympathetic control of cardiac function.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: February 8, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeffrey L. Ardell, Kalyanam Shivkumar
  • NEUROSTIMULATION IN A NEURAL FULCRUM ZONE FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION
    Publication number: 20220016429
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
    Type: Application
    Filed: July 30, 2021
    Publication date: January 20, 2022
    Applicants: LivaNova USA, Inc., EAST TENNESSEE STATE UNIVERSITY
    Inventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
  • Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction
    Patent number: 11077304
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: August 3, 2021
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
  • Implantable neurostimulator-implemented method utilizing multi-modal stimulation parameters
    Patent number: 10974050
    Abstract: Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: April 13, 2021
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell, Gregory A. Ordway
  • Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction
    Patent number: 10967184
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: April 6, 2021
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
  • MONITORING AND MODULATION OF PARASYMPATHETIC NERVOUS SYSTEM
    Publication number: 20200324116
    Abstract: The present invention provides systems and methods for monitoring cardiac autonomic nervous system activity and modulating parasympathetic control of cardiac function.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 15, 2020
    Inventors: Jeffrey L. Ardell, Kalyanam Shivkumar
  • NEUROSTIMULATION IN A NEURAL FULCRUM ZONE FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION
    Publication number: 20190344082
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
    Type: Application
    Filed: May 24, 2019
    Publication date: November 14, 2019
    Applicants: LivaNova USA, Inc., EAST TENNESSEE STATE UNIVERSITY
    Inventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
  • Fine resolution identification of a neural fulcrum for the treatment of chronic cardiac dysfunction
    Patent number: 10463859
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone may be identified by monitoring a patient's response to incrementally increased intensity settings at a first frequency. If the incremental intensity increases do not result in the identification of the neural fulcrum zone, the frequency may be changed to provide finer resolution identification of the neural fulcrum zone.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: November 5, 2019
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Bruce H. KenKnight, Imad Libbus, Badri Amurthur, Jeffrey L. Ardell
  • Dynamic stimulation adjustment for identification of a neural fulcrum
    Patent number: 10426961
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: October 1, 2019
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
  • NEUROSTIMULATION AND RECORDING OF PHYSIOLOGICAL RESPONSE FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION
    Publication number: 20190168001
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
    Type: Application
    Filed: February 1, 2019
    Publication date: June 6, 2019
    Applicants: LIVANOVA USA, INC., EAST TENNESSEE STATE UNIVERSITY
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
  • Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction
    Patent number: 10300284
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: May 28, 2019
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
  • Cardiac neuromodulation and methods of using same
    Patent number: 10279180
    Abstract: A method of treating heart failure in a patient is disclosed that includes implanting a stimulation device into the identified patient to electrically stimulate the spinal cord, and activating the device to deliver electrical stimulation to the spinal cord.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: May 7, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Robert D. Foreman, Jeffrey L. Ardell, John A. Armour, Michael J. L. DeJongste, Bengt G. S. Linderoth
  • RESPONSIVE NEUROSTIMULATION FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION
    Publication number: 20190126045
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
    Type: Application
    Filed: December 27, 2018
    Publication date: May 2, 2019
    Applicants: LivaNova USA, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
  • Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction
    Patent number: 10195438
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: February 5, 2019
    Assignees: Cyberonics, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
  • Responsive neurostimulation for the treatment of chronic cardiac dysfunction
    Patent number: 10166391
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: January 1, 2019
    Assignees: Cybertronics, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
  • IMPLANTABLE NEUROSTIMULATOR-IMPLEMENTED METHOD UTILIZING MULTI-MODAL STIMULATION PARAMETERS
    Publication number: 20180361158
    Abstract: Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.
    Type: Application
    Filed: June 14, 2018
    Publication date: December 20, 2018
    Applicants: Cyberonics, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell, Gregory A. Ordway
  • DYNAMIC STIMULATION ADJUSTMENT FOR IDENTIFICATION OF A NEURAL FULCRUM
    Publication number: 20180243566
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 30, 2018
    Applicants: Cyberonics, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell