Patents by Inventor Jeffrey L. Fortman

Jeffrey L. Fortman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid polyketide synthases
    Patent number: 11505791
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: November 22, 2022
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE
    Publication number: 20220119783
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Application
    Filed: December 29, 2021
    Publication date: April 21, 2022
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Recombinant host cells for the production of malonate
    Patent number: 11248215
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: February 15, 2022
    Assignee: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Hybrid Polyketide Synthases
    Publication number: 20200270597
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Application
    Filed: December 2, 2019
    Publication date: August 27, 2020
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE
    Publication number: 20200071733
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Application
    Filed: October 7, 2019
    Publication date: March 5, 2020
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Hybrid polyketide synthases
    Patent number: 10494625
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: December 3, 2019
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Recombinant host cells for the production of malonate
    Patent number: 10472653
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: November 12, 2019
    Assignee: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Host cells and methods for producing diacid compounds
    Patent number: 9951345
    Abstract: The present invention provides for a method of producing one or more fatty acid derived dicarboxylic acids in a genetically modified host cell which does not naturally produce the one or more derived fatty acid derived dicarboxylic acids. The invention provides for the biosynthesis of dicarboxylic acid ranging in length from C3 to C26. The host cell can be further modified to increase fatty acid production or export of the desired fatty acid derived compound, and/or decrease fatty acid storage or metabolism.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: April 24, 2018
    Assignee: The Regents of the University of California
    Inventors: Eric J. Steen, Jeffrey L. Fortman, Jeffrey A. Dietrich, Jay D. Keasling
  • Producing alpha-olefins using polyketide synthases
    Patent number: 9856461
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an ?-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the ?-olefin.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: January 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Leonard Katz, Eric J. Steen, Jay D Keasling
  • RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE
    Publication number: 20170362614
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Application
    Filed: June 19, 2017
    Publication date: December 21, 2017
    Applicant: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Recombinant host cells for the production of malonate
    Patent number: 9816114
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: November 14, 2017
    Assignee: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Host cells and methods for producing 1-deoxyxylulose 5-phosphate (DXP) and/or a DXP derived compound
    Patent number: 9637766
    Abstract: The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP derived compounds, comprising: (a) a mutant RibB, or functional variant thereof, capable of catalyzing xylulose 5-phoshpate and/or ribulose 5-phospate to DXP, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: May 2, 2017
    Assignee: The Regents of the University of California
    Inventors: James Kirby, Jeffrey L. Fortman, Minobu Nishimoto, Jay D. Keasling
  • HYBRID POLYKETIDE SYNTHASES
    Publication number: 20170015990
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Application
    Filed: May 2, 2016
    Publication date: January 19, 2017
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Host Cells and Methods for Producing 1-Deoxyxylulose 5-phosphate (DXP) and/or a DXP Derived Compound
    Publication number: 20160298153
    Abstract: The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP derived compounds, comprising: (a) a mutant RibB, or functional variant thereof, capable of catalyzing xylulose 5-phoshpate and/or ribulose 5-phospate to DXP, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 13, 2016
    Applicant: The Regents of the University of California
    Inventors: James Kirby, Jeffrey L. Fortman, Minobu Nishimoto, Jay D. Keasling
  • Host cells and methods for producing 1-deoxyxylulose 5-phosphate (DXP) and/or a DXP derived compound
    Patent number: 9382553
    Abstract: The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP derived compounds, comprising: (a) a mutant RibB, or functional variant thereof, capable of catalyzing xylulose 5-phosphate and/or ribulose 5-phosphate to DXP, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: July 5, 2016
    Assignee: The Regents of the University of California
    Inventors: James Kirby, Jeffrey L. Fortman, Minobu Nishimoto, Jay D. Keasling
  • RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE
    Publication number: 20160177345
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Application
    Filed: March 6, 2013
    Publication date: June 23, 2016
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Hybrid polyketide synthases
    Patent number: 9334514
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: May 10, 2016
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • PRODUCING ALPHA-OLEFINS USING POLYKETIDE SYNTHASES
    Publication number: 20160068827
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an ?-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the ?-olefin.
    Type: Application
    Filed: September 14, 2015
    Publication date: March 10, 2016
    Inventors: Jeffrey L. Fortman, Leonard Katz, Eric J. Steen, Jay D. Keasling
  • Host cells and methods for producing isoprenyl alkanoates
    Patent number: 9200298
    Abstract: The invention provides for a method of producing an isoprenyl alkanoate in a genetically modified host cell. In one embodiment, the method comprises culturing a genetically modified host cell which expresses an enzyme capable of catalyzing the esterification of an isoprenol and a straight-chain fatty acid, such as an alcohol acetyltransferase (AAT), wax ester synthase/diacylglycerol acyltransferase (WS/DGAT) or lipase, under a suitable condition so that the isoprenyl alkanoate is produced.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: December 1, 2015
    Assignee: The Regents of the University of California
    Inventors: Taek Soon Lee, Jeffrey L. Fortman, Jay D. Keasling
  • Producing dicarboxylic acids using polyketide synthases
    Patent number: 9040282
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: May 26, 2015
    Assignee: The Regents of the University of California
    Inventors: Leonard Katz, Jeffrey L Fortman, Jay D Keasling