Patents by Inventor Jeffrey L. GUSTAFSON

Jeffrey L. GUSTAFSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SELECTIVE BTK IRREVERSIBLE INHIBITORS
    Publication number: 20220306638
    Abstract: The invention provides a series of conformationally stable and selective, irreversible kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds. The compounds herein are atropisomers having increased kinase selectivity and are for use in treating conditions that benefit from selective BTK kinase inhibition.
    Type: Application
    Filed: June 23, 2020
    Publication date: September 29, 2022
    Applicant: SAN DIEGO STATE UNIVERSITY FOUNDATION
    Inventors: Jeffrey L. GUSTAFSON, Sean Thomas TOENJES, Samuel T. ALBRIGHT, Ramsey HAZIN
  • Atropisomerism for increased kinase inhibitor selectivity
    Patent number: 11345707
    Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: May 31, 2022
    Assignee: San Diego State University (SDSU) Foundation
    Inventors: Jeffrey L. Gustafson, Davis E. Smith, David Hecht, Isaac Marquez, Sean Toenjes
  • Atropisomerism for enhanced kinase inhibitor selectivity
    Patent number: 10934300
    Abstract: The invention provides a series of conformationally stable and selective kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds. The compounds herein are atropisomers having increased kinase selectivity, and are for use in treating conditions that benefit from selective kinase inhibition.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: March 2, 2021
    Assignee: San Diego State University (SDSU) Foundation
    Inventors: Jeffrey L. Gustafson, Sean T. Toenjes, Sean M. Maddox
  • ATROPISOMERISM FOR ENHANCED KINASE INHIBITOR SELECTIVITY
    Publication number: 20200165258
    Abstract: The invention provides a series of conformationally stable and selective kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds. The compounds herein are atropisomers having increased kinase selectivity, and are for use in treating conditions that benefit from selective kinase inhibition.
    Type: Application
    Filed: June 21, 2018
    Publication date: May 28, 2020
    Applicant: San Diego State University Research Foundation
    Inventors: Jeffrey L. GUSTAFSON, Sean T. TOENJES, Sean M. MADDOX
  • ATROPISOMERISM FOR INCREASED KINASE INHIBITOR SELECTIVITY
    Publication number: 20200131191
    Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.
    Type: Application
    Filed: December 18, 2019
    Publication date: April 30, 2020
    Applicant: SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Jeffrey L. GUSTAFSON, Davis E. SMITH, David HECHT, Isaac MARQUEZ, Sean TOENJES
  • Atropisomerism for increased kinase inhibitor selectivity
    Patent number: 10550124
    Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: February 4, 2020
    Assignee: San Diego State University Foundation
    Inventors: Jeffrey L. Gustafson, Davis E. Smith, David Hecht, Isaac Marquez, Sean Toenjes
  • ATROPISOMERISM FOR INCREASED KINASE INHIBITOR SELECTIVITY
    Publication number: 20180230154
    Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.
    Type: Application
    Filed: August 15, 2016
    Publication date: August 16, 2018
    Applicant: SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Jeffrey L. GUSTAFSON, Davis E. SMITH, David HECHT, Isaac MARQUEZ, Sean TOENJES