Abstract: Methods and apparatus relating to light amplification technology that has the ability to transform and amplify light to be seen in the visible spectrum by the user (FIG. 2). The biologically-based light amplification system including a reaction center, a proton gradient area, and a light amplification area, and may be configured such that light entering the system through the reaction center produces a proton gradient, which in turn acts upon reactants in the proton gradient area, and then causes a product to enter the light amplification area and thereby drive a bioluminescent or phosphorescent reaction to amplify the light The methods and apparatus use solely biological processes without any external power supply.

Abstract: An accelerometer 100 which includes a bracket 110, a pair of electrodes 210/220/230/240/250, a first electrically conductive foam 120, a second electrically conductive foam 130, wherein the first electrically conductive foam and the second electrically conductive foam are inserted between the pair of electrodes and the bracket.

Abstract: Electrochemical impedance-based label-free and rapid biosensor for select bodily fluid biomolecule levels. Monoclonal antibodies to of biomolecule such as Cortisol were covalently attached to a 16-mercaptohexadecanoic acid functionalized gold working electrode using zero-length crosslinkers N-(3-dimethylaminopropyl)-N-ethylcarbodiimide and 10 mM N-hydroxysulfosuccinimide. Cortisol was detected in phosphate buffered saline (simulated tear fluid) using a simple ferrocyanide reagent with a lower limit of detection of 18.73 pM and less than 10% relative standard deviation.

Abstract: Stents adapted to allow for monitoring an environment into which they have been inserted in a body, as well as methods of making and using such stents and systems involving such stents. Such stents allow for the detection and treatment of side effects and deleterious results of stent insertion. These stent are makeable by processes and methods involving three dimensional printing.

Abstract: Synthesis of novel and unique PAMAM (poly-amidoamine) polymers. PAMAM polymers can be grown by systematic alternation between ethylenediamine (EDA) and methacrylate. By taking advantage of the alternating terminal ends, successive generations G1 and G0.5 were combined under acidic conditions with Pluronic P123 as a liquid-crystal template. The resulting polymer was imaged with TEM and the product was circular and amorphous of no characteristic size ranging between about 5 nm to about 600 nm, with remarkable electrochemical activity unseen in any of the generations of PAMAM. Applications of this electroactive poly-amidoamine organic polymer include use as a new electron transfer reagent for amperometric biosensors.

Abstract: An accelerometer 100 which includes a bracket 110, a pair of electrodes 210/220/230/240/250, a first electrically conductive foam 120, a second electrically conductive foam 130, wherein the first electrically conductive foam and the second electrically conductive foam are inserted between the pair of electrodes and the bracket.

Abstract: A prosthetic device including an internal frame assembled from multiple longitudinal members and multiple transverse members, wherein each member is substantially planar and defines peripheral slots, and wherein the longitudinal members and transverse members are arranged to mate with one another to join the longitudinal members with the transverse members. In certain embodiments, a first group of longitudinal members is radially arranged relative to a central axis extending through the transverse members, and a second group of longitudinal members is tangentially arranged relative to the central axis, preferably with lateral edges of the second group of longitudinal members extending between two different longitudinal members of the first group of longitudinal members to provide enhanced torsional rigidity. An outer shaping member, which may be tubular in shape, may be arranged to cover at least a portion of the internal frame.

Abstract: An electrochemical sensor (100), comprising a substrate (105), two electrodes (130) and (140) screen printed onto said substrate, an elastomer (150) disposed over one of said plurality of screen printed electrodes, and one or more electroactive species disposed within said elastomer.

Abstract: Methods and devices to continuously measure electrochemical activity of one or more biochemical or molecular markers (FIG. 9). A substrate having electronics for measuring electrochemical activity and a plurality of electrodes such that the electrodes are in contact with the subcutaneous layer are attached to subject's skin or intravenously. The devices measure a biochemical process associated with one or more biochemical or molecular markers in vivo by detecting an electrochemical signal in subcutaneous layer (or intravenously) using the plurality of electrodes.

Abstract: The present invention relates to a diagnostic device and methods of using the same for diagnostic assays for monitoring the presence of biological samples wherein the device allows for the determination of at least two assay components on one sensor. More specifically, the invention relates to a multi-marker electrochemical impedance spectroscopy sensor comprising a plurality of molecular recognition elements wherein the sensor comprises multiple different molecular recognition element types that are tuned in a manner that alters the frequency of the molecular recognition element type such that it is at a detectably different frequency to the frequency of other molecular recognition element types on the same sensor.

Abstract: An improved method for the design and development of high performance hybrid devices having biological and nonbiological components. A figure of merit is developed for the biological component or components. The component is subjected to various environmental variables as it or its biological source organism is grown. The biological component is force adapted to cause its figure of merit to reach a goal or an acceptable measure. The biological component is used in hybrid constructs that may be nanostructures, given the small size of the biological parts. In one specific embodiment, force-adapted chlorosomes of C. aurantiacus enhance performance of a silicon photovoltaic cell. The bacteria, Chloroflexus aurantiacus (C. aurantiacus), strain J-10-f1, has the A.T.C.C. designation number 29366, having been deposited in July, 1976.