Abstract: Provided herein, in certain embodiments, are compounds of Formula I: or a pharmaceutically acceptable salt or a solvate thereof, compositions comprising a compounds of Formula I, or a pharmaceutically acceptable salt or a solvate thereof, and uses thereof such as in treating certain diseases or disorders (e.g., cancer, fibrosis, chronic inflammation).

Abstract: Provided herein are methods for next generation sequencing a target using universal adapter technologies and identifying and reducing error by distinguishing the signals from sequencing the target based on the location on the flow cell of the signals from sequencing the sample identifying region(s) of the adapters.

Abstract: The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein, in certain embodiments, are compounds of Formula I. or a pharmaceutically acceptable salt or a solvate thereof, compositions comprising a compounds of Formula I, or a pharmaceutically acceptable salt or a solvate thereof, and uses thereof such as in treating certain diseases or disorders (e.g., cancer, fibrosis, chronic inflammation).

Abstract: A wine funnel for facilitating the transfer of wine from a bottle to a decanter includes a frustoconical housing having a top wall, a substantially continuous outer wall, and a lower end. Centrally positioned on the top wall is an elevated ball for dispersing wine into smaller, multidirectional streams. The top wall also includes a plurality of concentric grooves that trap sediment from wine deflected by the ball. The grooves are in fluid communication with an internal spiraled passageway having a plurality of venturi ports for efficiently importing ambient air into wine as it flows through the housing and into a decanter or wine glass.

Abstract: Provided herein, in certain embodiments, are compounds of Formula I: or a pharmaceutically acceptable salt or a solvate thereof, compositions comprising a compounds of Formula I, or a pharmaceutically acceptable salt or a solvate thereof, and uses thereof such as in treating certain diseases or disorders (e.g., cancer, fibrosis, chronic inflammation).

Abstract: Methods for treatment of fibrotic diseases using compounds of formula I wherein RA is hydrogen, R7 and R8 are independently selected from H and SO2NR3R4, one of R7 and R8 is hydrogen, and R1, R2, R3, and R4 are each independently selected from H, alkyl, heteroalkyl, cycloalkyl, arylcycloalkyl, aryl, heteroaryl, heterocycloalkyl, and each of NR1R2 and NR3R4 can independently combine to form a heterocycloalkyl, and wherein said alkyl, heteroalkyl, cycloalkyl, arylcycloalkyl, aryl, heteroaryl, or heterocycloalkyl may be optionally substituted, or a pharmaceutically acceptable salt, ester, amide, stereoisomer, geometric isomer or prodrug thereof.

Abstract: Disclosed are systems and methods for dynamically routing pickers and autonomous vehicles to avoid areas closed to travel by the autonomous vehicles within a warehouse. A processor in communication with an autonomous vehicle and an electronic device operated by a user (e.g., handheld device) may, in response to detecting that the electronic device diverges from a path of the autonomous vehicle, provide, for display on the electronic device, information about the product. The processor may then determine a rendezvous location for the autonomous vehicle based on a location of the product. The processor may then instruct the autonomous vehicle to navigate to the rendezvous location and transmit the rendezvous location to the electronic device.

Abstract: Formulations of tegavivint and related compounds, methods of making such formulations and methods of treating various conditions utilizing such formulations.

Abstract: Methods for treatment of fibrotic diseases using compounds of formula I wherein RA is hydrogen, R7 and R8 are independently selected from H and SO2NR3R4, one of R7 and R8 is hydrogen, and R1, R2, R3, and R4 are each independently selected from H, alkyl, heteroalkyl, cycloalkyl, arylcycloalkyl, aryl, heteroaryl, heterocycloalkyl, and each of NR1R2 and NR3R4 can independently combine to form a heterocycloalkyl, and wherein said alkyl, heteroalkyl, cycloalkyl, arylcycloalkyl, aryl, heteroaryl, or heterocycloalkyl may be optionally substituted, or a pharmaceutically acceptable salt, ester, amide, stereoisomer, geometric isomer or prodrug thereof.

Abstract: Formulations of tegavivint and related compounds, methods of making such formulations and methods of treating various conditions utilizing such formulations.

Abstract: Formulations of tegavivint and related compounds, methods of making such formulations and methods of treating various conditions utilizing such formulations.

Abstract: A wine-glass polisher includes a housing having at least one cleaning chamber defined by a bottom wall and at least one sidewall. Extending from the sidewall is a wine-glass holder including a horizontal arm having a C-shaped gripping member at a distal end for holding the stem of an inverted wine glass. Immediately above the gripping member is a motorized disc for engaging the base of a wine glass to rotate it during a cleaning and drying cycle. Mounted on the sidewall, below the wine-glass holder, is an upper dispensing nozzle for projecting either drying air or steam onto the exterior surface of a wine glass. Upwardly extending from the bottom wall of the cleaning chamber is a lower dispensing nozzle for projecting drying air or hot water onto the interior surface of a wine glass. Hot water and air are sequentially delivered to the nozzles to clean and subsequently dry a wine glass.

Abstract: A cover assembly for use to protect the contents of a boat including a pair of channels, a semi-rigid guide member slidably disposed within a passage of one of the channels, a crossrod supported on each end by one of the pair of channels and connected on one end to the semi-rigid guide member, and a cover sheet connected to the crossrod. The cover assembly configured such that as a retraction mechanism moves the semi-rigid guide member in the passage, the cover is extended or retracted to the desired position.

Abstract: A wine-glass polisher includes a base unit having a frustoconical cleaning chamber removably fastened thereto. A steam generator, an air heater and a vacuum pump are each in fluid communication with the cleaning chamber. A portion of the steam and hot air is directed to a channel formed in the chamber outer wall. An annular, U-shaped baffle surrounding the open top is in fluid communication with the channel for projecting the steam and hot air downwardly toward a wine glass below. A remaining portion of the heated air and steam is delivered directly to the upper surface of the base unit to clean and dry the interior surface of the glass. A controller first initiates a polishing cycle by activating the vacuum pump and steam generator. Upon expiration of the predetermined duration, the controller activates the blower to dry the exterior and interior surfaces of the glass.

Abstract: A cover assembly for use to protect the contents of a boat including a pair of channels, a semi-rigid guide member slidably disposed within a passage of one of the channels, a crossrod supported on each end by one of the pair of channels and connected on one end to the semi-rigid guide member, and a cover sheet connected to the crossrod. The cover assembly configured such that as a retraction mechanism moves the semi-rigid guide member in the passage, the cover is extended or retracted to the desired position.

Abstract: The present invention provides methods and apparatus in which a surgical retractor comprises a plurality of mechanically coupled tissue retaining walls that are guided into position along one or more guides previously implanted into the patient. The walls are preferably coupled by pivots, so that separating some of the walls from one another opens an operating space. There are preferably two guides, which are driven or screwed into the pedicles of vertebrae, or other bone. Oversized channels are best disposed in a frame, which also serves to hold lock the walls apart. Various convenience features are contemplated including a web disposed between the walls, which expands as the walls are separated. Also contemplated are projections from near the bottoms of one or more of the walls, which can alternatively or additionally help to hold the underlying tissue in place.

Abstract: The present invention provides methods and apparatus in which a surgical retractor comprises a plurality of mechanically coupled tissue retaining walls that are guided into position along one or more guides previously implanted into the patient. The walls are preferably coupled by pivots, so that separating some of the walls from one another opens an operating space. There are preferably two guides, which are driven or screwed into the pedicles of vertebrae, or other bone. Oversized channels are best disposed in a frame, which also serves to hold lock the walls apart. Various convenience features are contemplated including a web disposed between the walls, which expands as the walls are separated. Also contemplated are projections from near the bottoms of one or more of the walls, which can alternatively or additionally help to hold the underlying tissue in place.

Abstract: The present invention provides methods and apparatus in which a surgical retractor comprises a plurality of mechanically coupled tissue retaining walls that are guided into position along one or more guides previously implanted into the patient. The walls are preferably coupled by pivots, so that separating some of the walls from one another opens an operating space. There are preferably two guides, which are driven or screwed into the pedicles of vertebrae, or other bone. Since practical considerations will usually mean that the guides are completely parallel to one another, the retractor has oversized channels to receive the guides. The channels are best disposed in a frame, which also serves to hold lock the walls apart. Various convenience features are contemplated including a web disposed between the walls, which expands as the walls are separated.

Abstract: The present invention provides methods and apparatus in which a surgical retractor comprises a plurality of mechanically coupled tissue retaining walls that are guided into position along one or more guides previously implanted into the patient. The walls are preferably coupled by pivots, so that separating some of the walls from one another opens an operating space. There are preferably two guides, which are driven or screwed into the pedicles of vertebrae, or other bone. Since practical considerations will usually mean that the guides are not generally parallel to one another, the guides are capable of polyaxial movement with respect to the pedicles, and retractor is provided with oversized channels to receive the guides. The channels may be conveniently disposed in a frame, which also serves to hold lock the walls apart. Various convenience features are contemplated including a web disposed between the walls, which expands as the walls are separated.