Abstract: An electronic device, while displaying a representation of a piece of music, detects a first input event at a location corresponding to the representation of the piece of music, and in response, provides tactile feedback that corresponds to at least a subset of beats of the piece of music. Subsequently, in response to detecting a second input event at the location corresponding to the representation of the piece of music, the electronic device ceases to provide the tactile feedback that corresponds to the beats of the piece of music.

Abstract: In some embodiments, an electronic device optionally identifies a person's face, and optionally performs an action in accordance with the identification. In some embodiments, an electronic device optionally determines a gaze location in a user interface, and optionally performs an action in accordance with the determination. In some embodiments, an electronic device optionally designates a user as being present at a sound-playback device in accordance with a determination that sound-detection criteria and verification criteria have been satisfied. In some embodiments, an electronic device optionally determines whether a person is further or closer than a threshold distance from a display device, and optionally provides a first or second user interface for display on the display device in accordance with the determination. In some embodiments, an electronic device optionally modifies the playing of media content in accordance with a determination that one or more presence criteria are not satisfied.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: Aspects of the present disclosure relate to the sharing of synchronization information corresponding to content among devices in a communication network. An originating device collects synchronization information related to the presentation of content to a user via the originating device. The synchronization information is defined according to reference points related to the presentation of the content to the user via the originating device, including a current state of the presentation of the content and/or additional information obtained during the presentation of the content. Based on detection of a synchronization event, the originating device transmits the collected synchronization information, resulting in the receipt of the synchronization information by one or more receiving devices. Thereafter, the presentation of the content to the user on one of the receiving devices can incorporate the synchronization information collected and transmitted by the originating device.

Abstract: A positron emission tomography (PET) scanner is provided having a plurality of detector subsystems, including processing circuitry to determine, for each detector subsystem of the plurality of detector subsystems, a singles count loss correction factor of the detector subsystem; determine, for each detector subsystem pair of a plurality of pairs of the detector subsystems, a coincidence count loss correction factor for the detector subsystem pair; calculate a scanner coincidence count loss correction factor for the PET scanner based on the coincidence count loss correction factors determined for the plurality of pairs of the detector subsystems; and reconstruct an image based on the calculated scanner count loss correction factor and scan data acquired from a scan of a patient performed using the PET scanner.

Abstract: Systems and methods for using image analysis techniques to assess unsafe driving conditions by a vehicle operator are discloses. According to aspects, a computing device may access and analyze image data depicting the vehicle operator. In analyzing the image, the computing device may measure certain visible metrics as depicted in the image data and compare the metrics to corresponding threshold values, and may accordingly determine whether the vehicle operator is exhibiting an unsafe driving condition. The computing device may generate and present alerts that indicate any determined unsafe driving condition.

Abstract: Systems and methods for forming aqueous based, water-soluble polymer slurry systems may include (1) a liquid phase which may be a suspension comprised of salt, water, and a water-soluble organic solvent and (2) a solid phase which may comprise a water-soluble polymer powder. The aqueous based, water-soluble polymer slurry systems may optimize processing of the suspension package so that it may slurry in low and high salt tolerance polymers, and the finished product can survive over 30 days at an approximately 120-degree Fahrenheit aging temperature, thereby overcoming economic performance and stability challenges through its high flash point, long shelf-life, high-temperature tolerance, and low cost.

Abstract: A coagent masterbatch comprising a semi-crystalline polyolefin carrier resin and an alkenyl-functional coagent. A peroxide curable formulation comprising the coagent masterbatch and a polyolefin compound. A method of making the masterbatch and formulation; a peroxide-cured polyolefin product prepared therefrom; a manufactured article comprising or made from the masterbatch, formulation, or product; and a method of using the manufactured article.

Abstract: A display system can include a head-mounted display configured to project light to an eye of a user to display virtual image content at different amounts of divergence and collimation. The display system can include an inward-facing imaging system images the user's eye and processing electronics that are in communication with the inward-facing imaging system and that are configured to obtain an estimate of a center of rotation of the user's eye. The display system may render virtual image content with a render camera positioned at the determined position of the center of rotation of said eye.

Abstract: Disclosed herein is a transportable bio-cement comprising a desiccated microorganism package; where the microorganism package comprises one or more microorganisms; a first binder, where the first binder is produced by the microorganism; and where the microorganism has protected itself by a layer of the first binder; where the transportable bio-cement is devoid of moisture. Disclosed herein too is a method of manufacturing a transportable dry composition comprising blending together a microorganism package; a nutrient; and a liquid; activating the microorganism package to produce a first binder; subjecting the microorganism package to desiccation to form a transportable bio-cement; and blending the transportable bio-cement with an aggregate to form a bio-concrete; where the aggregate comprises a substrate, a second binder, and a liquid.

Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.

Abstract: Overcoming localization errors in geographic regions where a global positioning system signal is obstructed is provided. A system can identify a geographic location with a localization error. In response, the system can supplement the global positioning system data associated with the geographic location with supplemental data to generate supplemental global positioning system data. Additionally, an operational state of a vehicle is controlled based on the supplemental global positioning system data.

Abstract: An electronic device with a touch-sensitive surface, a display, and one or more tactile output generators displays, on the display, a respective user interface element within a user interface region. The device detects a gesture on the touch-sensitive surface for moving the respective user interface element by a respective amount. In response, in accordance with a determination that moving the respective user interface element by the respective amount would cause the respective user interface element to move beyond a predefined limit, the device generates a respective tactile output via the tactile output generators and moves the respective user interface element by the respective amount and beyond the predefined limit. In response to detecting liftoff of a contact used to perform the gesture, the device at least partially reverses the movement of the respective user interface element, such that the respective user interface element is moved to the predefined limit.

Abstract: Systems and methods relate to processing digital pathology images. More specifically, techniques include accessing a digital pathology image that depicts a section of a biological sample, wherein the digital pathology image comprises regions displaying reactivity to a plurality of stains. For each of a plurality of tiles of the digital pathology image, a local-density measurement is calculated for each of a plurality of biological object types. One or more spatial-distribution metrics may be generated for the biological object types based at least in part on the calculated local-density measurements. A tumor immunophenotype may then be generated for the digital pathology image based at least in part on the local-density measurements or the one or more spatial-distribution metrics.

Abstract: The present disclosure provides a multilayer film. The multilayer film includes at least two layers including a sealant layer and a second layer in contact with the sealant layer. The sealant layer contains (A) a first ethylene-based polymer having a density from 0.900 g/cc to 0.925 g/cc and a melt index from 0.5 g/10 min to 30 g/10 min; and (B) a polyethylene-polydimethylsiloxane block copolymer having a weight average molecular weight from 1,000 g/mol to 10,000 g/mol. The second layer contains a second ethylene-based polymer.

Abstract: A process to form a rheology modified composition, the process comprising applying radiation, and optionally heat, to a composition that comprises at least the following component: a) an olefin-based polymer comprising a total unsaturation ?0.20 /1000 C; and wherein the radiation is applied using an electron beam (e-beam) at a dosage selected from 0.1 MRad to 1.5 MRad; and wherein component a is selected from a telechelic polyolefin of the formula A1L1L2A2, an unsaturated polyolefin of the formula A1L1, or an ethylene/alpha-olefin interpolymer. A process to form a rheology modified composition, the process comprising applying heat, and optionally radiation, to a composition that comprises at least the following components: a) an olefin-based polymer, as described above, comprising a total unsaturation ?0.20/1000 C; b) from 1.0 to 100 ppm of a peroxide, based on the weight of the composition.

Abstract: A computing device having a touch-sensitive surface and a display, detects a stylus input on the touch-sensitive surface while displaying a user interface. A first operation is performed in the user interface in accordance with a determination that the stylus input includes movement of the stylus across the touch-sensitive surface while the stylus is detected on the touch-sensitive surface. A second operation different from the first operation is performed in the user interface in accordance with a determination that the stylus input includes rotation of the stylus around an axis of the stylus while the stylus is detected on the touch-sensitive surface. A third operation is performed in the user interface in accordance with a determination that the stylus input includes movement of the stylus across the touch-sensitive surface and rotation of the stylus around an axis of the stylus while the stylus is detected on the touch-sensitive surface.

Abstract: Systems and methods for detecting roadway lane boundaries are disclosed herein. One embodiment receives image data of a portion of a roadway; receives historical vehicle trajectory data for the portion of the roadway; generates, from the historical vehicle trajectory data, a heatmap indicating, for a given pixel in the heatmap, an extent to which the given pixel coincides spatially with vehicle trajectories in the historical vehicle trajectory data; and projects the heatmap onto the image data to generate a composite image that is used in training a neural network to detect roadway lane boundaries, the projected heatmap acting as supervisory data. The trained neural network is deployed in a vehicle to generate and save map data including detected roadway lane boundaries for use by other vehicles or to control operation of the vehicle itself based, at least in part, on roadway lane boundaries detected by the trained neural network.

Abstract: A method for clock switching includes propagating a first clock signal through a first clock path, propagating a second clock signal through a second clock path, generating a first delay control signal based on the first clock signal, and generating a second delay control signal based on the second clock signal. The method also includes, in a first mode, coupling the first clock path to a delay circuit and inputting the first delay control signal to a control input of the delay circuit. The method also includes, in a second mode, coupling the second clock path to the delay circuit and inputting the second delay control signal to the control input of the delay circuit.

Abstract: Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a Superoxide Dismutase 1 (SOD1) gene. The SOD1 RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an SOD1 gene. Pharmaceutical compositions that include one or more SOD1 RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described SOD1 RNAi agents to central nervous system (CNS) tissue, in vivo, provides for inhibition of SOD1 gene expression and a reduction in SOD1 activity, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including amyotrophic lateral sclerosis (ALS.).