Abstract: The specification relates to compounds of Formula (1): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cancer.

Abstract: A passive flow modulation device for a machine defining an axial direction and a radial direction, the passive flow modulation device including: a first ring with a first coefficient of thermal expansion; a second ring disposed coaxially with the first ring and positioned at least partially inward of the first ring along the radial direction, spaced from the first ring along the axial direction, or both, the first ring, the second ring, or both defining at least in part one or more passages, the second ring with a second coefficient of thermal expansion that is less than the first coefficient of thermal expansion to passively modulate a size of the one or more passages during operation.

Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Abstract: Disclosed herein is a simplified EMO linkage circuit that enables add-on equipment without retrofit, and eliminates the need for multi-contact EMO switches.

Abstract: A switch module includes multiple ports, each port electrically communicating with a port light emitting diode (LED), where each port LED is configured to emit light to indicate power delivery out of the port, and each port LED is configured to emit one of a plurality of light colors to indicate a power level delivered out of the port.

Abstract: Systems and methods for managing a redundant management module are provided. In this regard, a representative system, among others, includes first and second management modules that are configured to manage a computing device; and a programmable logic device that is configured to: instruct the first management module to manage the computing device responsive to detecting that the first management module is ready to manage the computing device, and instruct the second management module to manage the computing device responsive to detecting that the first management module failed to manage the computing device.

Abstract: Systems and methods for managing a redundant management module are provided. In this regard, a representative system, among others, includes first and second management modules that are configured to manage a computing device; and a programmable logic device that is configured to: instruct the first management module to manage the computing device responsive to detecting that the first management module is ready to manage the computing device, and instruct the second management module to manage the computing device responsive to detecting that the first management module failed to manage the computing device.

Abstract: A hardware and software system including a controller that can be operatively combined with several methods of display on a display screen under software and hardware control for the purpose of browsing through data stored in a memory device. The browsing of the data stored in a memory device is facilitated in such a way that it allows a rapid view of what contents are present and the organization of the material in the data, as well as rapid access to the items in the data involved. The controllers in the system have specialized functions for effecting various actions on the data displayed on the display screen in such a way that users can rapidly browse through the data involved. The methods of display may include interaction with CD-R, CD-RW, DVD, a portable optical large volume storage disk, a portable large volume non-optical storage medium, a TV, and an HDTV.

Abstract: A method for flipping pages of an electronic book via an electromechanical information browsing device that controls page flipping actions of information displayed as an e-book on a display device. The browsing device includes a controller that provides tactile feedback so as to lessen the user-interface differences between conventional books and e-books. Sensors and control mechanisms in the controller generate a series of electrical signals that are interpreted by the computer that displays the e-book to control various browsing operations, such as flipping pages, controlling a rate of page flipping, jumping to pre-set locations in the e-book, etc.

Abstract: In one embodiment, a system comprises a portable computing device comprising a first graphics controller and a first communication interface, and a turbo station comprising a second communication interface to manage communication with the portable computing device, and at least one auxiliary computing component coupled to the communication interface and configured to process cooperatively with the first graphics controller in the portable computing device.

Abstract: In one embodiment, a system comprises a portable computing device comprising a first graphics controller and a first communication interface, and a turbo station comprising a second communication interface to manage communication with the portable computing device, and at least one auxiliary computing component comprising a multi-core graphics engine coupled to the communication interface and configured to process cooperatively with the first graphics controller in the portable computing device.