Patents by Inventor Jeffrey Linnen

Jeffrey Linnen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240360435
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: July 12, 2024
    Publication date: October 31, 2024
    Applicant: Gen-Probe Incorporated
    Inventors: Kui GAO, Jijumon CHELLISERRY, Jeffrey LINNEN
  • Patent number: 12071615
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: August 27, 2024
    Assignee: Gen-Probe Incorporated
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • Publication number: 20220002707
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: September 27, 2021
    Publication date: January 6, 2022
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • Patent number: 11162091
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: November 2, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • Patent number: 11015185
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: May 25, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • Publication number: 20210139886
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: December 28, 2020
    Publication date: May 13, 2021
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • Publication number: 20190136225
    Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: April 26, 2017
    Publication date: May 9, 2019
    Inventors: Kui Gao, Jijumon Chelliserry, Jeffrey Linnen
  • Publication number: 20080108055
    Abstract: Compositions, methods and kits for detecting flavivirus nucleic acids. Particularly described are methods for detecting West Nile virus nucleic acids in the 3? non-coding region.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Applicant: GEN-PROBE INCORPORATED
    Inventors: Jeffrey Linnen, Reinhold Pollner, Wen Wu, Geoffrey Dennis, Paul Darby
  • Publication number: 20080081328
    Abstract: Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic acids.
    Type: Application
    Filed: October 15, 2007
    Publication date: April 3, 2008
    Applicant: GEN-PROBE INCORPORATED
    Inventors: Jeffrey LINNEN, Daniel KOLK, Janel DOCKTER, Damon GETMAN, Tadashi YOSHIMURA, Martha HO-SING-LOY, Reinhold POLLNER, Leslie STRINGFELLOW
  • Publication number: 20080020398
    Abstract: Compositions, methods and kits for detecting the nucleic acids of HIV-1, HIV-2, or the combination of HIV-1 and HIV-2. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers, including cross-reacting hybridization probes and cross-reacting amplification primers, for detecting very low levels of viral nucleic acids.
    Type: Application
    Filed: August 13, 2007
    Publication date: January 24, 2008
    Applicant: GEN-PROBE INCORPORATED
    Inventors: Jeffrey LINNEN, Wen WU
  • Publication number: 20070009953
    Abstract: Compositions, methods and kits for detecting flavivirus nucleic acids. Particularly described are methods for detecting very low levels of West Nile virus nucleic acids in the 5? non-coding/capsid region.
    Type: Application
    Filed: September 11, 2006
    Publication date: January 11, 2007
    Applicant: GEN-PROBE INCORPORATED
    Inventors: Jeffrey Linnen, Reinhold Pollner, Wen Wu, Geoffrey Dennis, Paul Darby
  • Publication number: 20060188912
    Abstract: Method of preparing a biological sample appropriate for use in a subsequent in vitro nucleic acid amplification reaction. The method involves a rapid, transient exposure to alkaline conditions which can be achieved by mixing an alkaline solution with a pH-buffered solution that includes a detergent and the biological sample to be tested for the presence of particular nucleic acid species using in vitro amplification. The invented method advantageously can improve detection of some target nucleic acids without substantially compromising detectability of others. The method is particularly useful for simultaneously preparing RNA and DNA templates that can be used in multiplex amplification reactions.
    Type: Application
    Filed: February 17, 2006
    Publication date: August 24, 2006
    Applicant: Gen-Probe Incorporated
    Inventors: Kui Gao, Michael Becker, Wen Wu, Jeffrey Linnen
  • Publication number: 20060134609
    Abstract: The present invention relates to oligonucleotides useful for determining the presence of SARS coronavirus in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, capture probes and amplification oligonucleotides, or used in various combinations thereof.
    Type: Application
    Filed: April 16, 2004
    Publication date: June 22, 2006
    Inventors: Jeffrey Linnen, Daniel Kacian, Norman Nelson, Damon Getman, Sangeetha Vijaysri
  • Publication number: 20050153282
    Abstract: Compositions, methods and kits for detecting the nucleic acids of HIV-1, HIV-2, or the combination of HIV-1 and HIV-2. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers, including cross-reacting hybridization probes and cross-reacting amplification primers, for detecting very low levels of viral nucleic acids.
    Type: Application
    Filed: December 16, 2004
    Publication date: July 14, 2005
    Applicant: Gen-Probe Incorporated
    Inventors: Jeffrey Linnen, Wen Wu