Abstract: The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecule and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells within the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28 or CH44.

Abstract: The present technology provides anti-Thyroid Stimulating Hormone Receptor (TSHR) multi-specific (e.g., bispecific) immunoglobulin-related compositions and methods of using the same to treat TSHR-associated pathologies including, but not limited to, thyroid cancers, T-ALL (T lineage acute lymphoblastic leukemia), multiple myeloma and Grave's disease. Kits for use in practicing the methods are also provided.

Abstract: An instrument includes a reagent management system. The reagent management system includes a plurality of reagent wells, each reagent well operable to contain a reagent of a plurality of reagents positioned therein. The reagent management system is operable to select a flow of reagent from one of the plurality of reagents. A flexible connection includes a laminate stack and includes a first flexible channel in fluid communication with the reagent management system. The first flexible channel is operable to route the flow of reagent therethrough. A flow cell includes a flow channel in fluid communication with the first flexible channel. The flow channel is operable to route the flow of reagent over analytes positioned in the flow channel. The flexible connection enables the flow cell to be moved by the instrument relative to a fixed reference point in the instrument.

Abstract: Described herein are small molecules, compositions, methods, and kits relating to the treatment of bacterial spot disease in plants, in particular in tomato. In certain aspects, described herein is a small molecule composition for the treatment of bacterial spot disease or bacterial speck disease in a subject in need thereof, comprising piperidine, pyrrolidine, hexanoic acid, or any combination thereof, present in an amount to treat the symptoms of bacterial spot disease or bacterial speck disease in a subject in need thereof. Further described herein are methods of use and kits comprising the same.

Abstract: A method performed by a docking station operable in a plurality of modes is disclosed. The method may include obtaining first data via a first interface of the docking station and second data via a second interface of the docking station, responsive to operating in a first mode of the plurality of modes. The first interface may be configured to couple the docking station to a computing device, and the second interface may be configured to communicate with a network. The method may also include obtaining third data via the second interface of the docking station, in lieu of the first interface, responsive to operating in a second mode of the plurality of modes. The method may further include selectively outputting the first data and the second data, or the third data, to a display based on whether the docking station operates in the first mode or the second mode.

Abstract: The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

Abstract: A docking station operable in a plurality of modes is disclosed. An example method includes obtaining first data via a first interface of the docking station configured to couple the docking station to a computing device and second data via a second interface of the docking station configured to communicate with a network, responsive to operating in a first mode, obtaining third data via the second interface of the docking station, responsive to operating in a second mode, and selectively outputting the first and the second data, or the third data, to a display based on whether the docking station operates in the first or the second mode. The selectively outputting includes determining that the computing device is not coupled to the docking station, and in response, processing the third data by an application installed in a secure sandbox, and outputting the processed third data to the display.

Abstract: A data platform for running a subset of cells in a notebook is provided. The data platform receives a run cells message from a notebook user interface (UI) application specifying the subset of cells to run. For each cell in the subset, the data platform runs the cell to generate a set of results, generates a cell execution stream using the results, stores the stream, and transmits the stream to the notebook UI application. The notebook UI application generates a display for the user using the cell execution stream. The data platform provides an efficient way to run specific cells in a notebook and display the results to the user.

Abstract: An example of a biotin-streptavidin cleavage composition includes a formamide reagent and a salt buffer. The formamide reagent is present in the biotin-streptavidin cleavage composition in an amount ranging from about 10% to about 50%, based on a total volume of the biotin-streptavidin cleavage composition. The salt buffer makes up the balance of the biotin-streptavidin cleavage composition. In some examples, the biotin-streptavidin cleavage composition is used to cleave library fragments from a solid support. In other examples, other mechanisms are used to cleave library fragments from a solid support.

Abstract: Systems and methods for vehicle-based determination of HD map update information. Sensor-equipped vehicles may determine locations of various detected objects relative to the vehicles. Vehicles may also determine the location of reference objects relative to the vehicles, where the location of the reference objects in an absolute coordinate system is also known. The absolute coordinates of various detected objects may then be determined from the absolute position of the reference objects and the locations of other objects relative to the reference objects. Newly-determined absolute locations of detected objects may then be transmitted to HD map services for updating.

Abstract: The disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.

Abstract: A system and method for identifying and authenticating a physical article to a virtual environment. A physical article, such as a decorative pin used in gameplay or some purchased article with anti-counterfeiting tag information, may be scanned by a mobile device and verified by a mobile device application. Such a process may uniquely identify a product as being associated with one particular customer, which may limit counterfeiting and may also allow the article to be incorporated in some form into a game or other virtual environment, such as in the form of an accessory for a game character.

Abstract: Methods and apparatuses related to federated search of multiple sources with conflict resolution are disclosed. A method may comprise obtaining a set of data ontologies (e.g., types, properties, and links) associated with a plurality of heterogeneous data sources; receiving a selection of a graph comprising a plurality of graph nodes connected by one or more graph edges; and transforming the graph into one or more search queries across the plurality of heterogeneous data sources. A method may comprise obtaining a first data object as a result of executing a first search query across a plurality of heterogeneous data sources; resolving, based on one or more resolution rules, at least the first data object with a repository data object; deduplicating data associated with at least the first data object and the repository data object prior to storing the deduplicated data in a repository that has a particular data model.

Abstract: A continuous glucose monitoring system may utilize electrode current (Isig) signals, Electrochemical Impedance Spectroscopy (EIS), and Vcntr values to optimize sensor glucose (SG) calculation in such a way as to enable reduction of the need for blood glucose (BG) calibration requests from users.

Abstract: The disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.

Abstract: A percutaneous circulatory support system includes a percutaneous circulatory support device having an impeller and a distal portion. A guidewire insertion aide is removably carried in the distal portion of the percutaneous circulatory support device. The guidewire insertion aide includes a tapered distal end portion initially in contact with the distal portion of the percutaneous circulatory support device. The guidewire insertion aide is configured to couple to a guidewire.

Abstract: A first turboexpander generator defines a portion of a first conduit flow passage. The first turboexpander generator is configured to decrease a temperature or pressure of a process stream flowing through the first turboexpander generator by generating electrical power from the process stream. A second turboexpander generator defines a portion of a second conduit flow passage. The second turboexpander generator is configured to decrease a temperature or pressure of a process stream flowing through the second turboexpander generator by generating electrical power from the process stream. The first and second conduit flow passages are arranged to carry fluid flow in parallel to one another. The first and the second turboexpander generator are substantially identical in critical dimensions and performance.

Abstract: Surgical drill guides have modular configurations and are adapted to accommodate a wide range of anatomy. The surgical drill guides are adapted to be removed while leaving a guide wire in its intended location in human bone. The distal end of the drill guide acts as a safety stop for the guide wire by preventing the guide wire from penetrating too far past the far side of the bone.

Abstract: An illustrative system includes an image sensor comprising a first pixel, a second pixel, a third pixel, and a fourth pixel. The system further includes a pixel-level broadband infrared cutoff filter that covers the second pixel and that is configured to prevent the second pixel from collecting infrared light having wavelengths included in a first range of wavelengths. The first, third, and fourth pixels are not covered by pixel-level broadband infrared cutoff filters configured to prevent the first, third, and fourth pixels from collecting infrared light having wavelengths included in the first range of wavelengths.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.