Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: Every year, professional classifiers at West Group manually classify over 350,000 headnotes, or abstracts of judicial opinions, across approximately 82,000 separate classes of the Key Number System. Although most headnotes are classified from the memory of the classifiers, a significant number are difficult and thus costly to classify manually. Accordingly, the inventors devised systems, methods, and software that facilitate manual classification of headnotes and documents generally and hard-to-classify headnotes particularly. One exemplary system provides a graphical user interface that concurrently displays an unclassified headnote, a ranked list of one or more candidate classes, a candidate class in combination with adjacent classes of the classification system, and at least one classified headnote that is associated with one of the candidate classes.

Abstract: Every year, professional classifiers at West Group manually classify over 350,000 headnotes, or abstracts of judicial opinions, across approximately 82,000 separate classes of the Key Number System. Although most headnotes are classified from the memory of the classifiers, a significant number are difficult and thus costly to classify manually. Accordingly, the inventors devised systems, methods, and software that facilitate manual classification of headnotes and documents generally and hard-to-classify headnotes particularly. One exemplary system provides a graphical user interface that concurrently displays an unclassified headnote, a ranked list of one or more candidate classes, a candidate class in combination with adjacent classes of the classification system, and at least one classified headnote that is associated with one of the candidate classes.

Abstract: Every year, professional classifiers at West Group manually classify over 350,000 headnotes, or abstracts of judicial opinions, across approximately 82,000 separate classes of the Key Number System. Although most headnotes are classified from the memory of the classifiers, a significant number are difficult and thus costly to classify manually. Accordingly, the inventors devised systems, methods, and software that facilitate manual classification of headnotes and documents generally and hard-to-classify headnotes particularly. One exemplary system provides a graphical user interface that concurrently displays an unclassified headnote, a ranked list of one or more candidate classes, a candidate class in combination with adjacent classes of the classification system, and at least one classified headnote that is associated with one of the candidate classes.

Abstract: Every year, professional classifiers at West Group manually classify over 350,000 headnotes, or abstracts of judicial opinions, across approximately 82,000 separate classes of the Key Number System. Although most headnotes are classified from the memory of the classifiers, a significant number are difficult and thus costly to classify manually. Accordingly, the inventors devised systems, methods, and software that facilitate manual classification of headnotes and documents generally and hard-to-classify headnotes particularly. One exemplary system provides a graphical user interface that concurrently displays an unclassified headnote, a ranked list of one or more candidate classes, a candidate class in combination with adjacent classes of the classification system, and at least one classified headnote that is associated with one of the candidate classes.