Patents by Inventor Jeffrey M. Axten

Jeffrey M. Axten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enantopselective synthesis of methyl phenidate
    Patent number: 6025502
    Abstract: The invention relates to an enantioselective method of making methylphenidate and derivatives thereof. The method involves use of a rhodium catalyst, and selectively produces the D-enantiomer of the methylphenidate derivative in excess of the L-enantiomer thereof. Furthermore, the method selectively produces the threo-diastereomer in excess of the erythro-diastereomer. The method is thus suitable for synthesis of D-threo-methylphenidate (the biologically active form of this compound) and derivatives thereof.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: February 15, 2000
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jeffrey David Winklter, Jeffrey M. Axten, Lori Krim