Patents by Inventor Jeffrey M. Friedman
Jeffrey M. Friedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10479051Abstract: A building panel, which includes a decorative assembly including a glass assembly which includes first and second layers of glass and a clear interlayer between said first and second layers of glass, said glass assembly being compliant with safety code ANSI Z97.Type: GrantFiled: September 28, 2016Date of Patent: November 19, 2019Inventors: Harold S Friedman, Jeffrey M Friedman, Viktor Tsvik
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Publication number: 20170015086Abstract: A building panel, which includes a decorative assembly including a glass assembly which includes first and second layers of glass and a clear interlayer between said first and second layers of glass, said glass assembly being compliant with safety code ANSI Z97.Type: ApplicationFiled: September 28, 2016Publication date: January 19, 2017Inventors: Harold S. FRIEDMAN, Jeffrey M. FRIEDMAN, Viktor TSVIK
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Patent number: 9469567Abstract: Building panel, in particular for use in elevator cars, includes a glass assembly having two layers of glass and a clear interlayer therebetween and which glass assembly is compliant with safety code ANSI Z97.1, a decorative sheet arranged alongside the first layer of glass, and a backing sheet arranged alongside the decorative sheet on an opposite side from the glass assembly. An optional support structure is arranged alongside the backing sheet on an opposite side from the decorative sheet. The decorative sheet may be a wood veneer.Type: GrantFiled: March 20, 2015Date of Patent: October 18, 2016Inventors: Harold S Friedman, Jeffrey M Friedman, Viktor Tsvik
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Publication number: 20160272538Abstract: Building panel, in particular for use in elevator cars, includes a glass assembly having two layers of glass and a clear interlayer therebetween and which glass assembly is compliant with safety code ANSI Z97.1, a decorative sheet arranged alongside the first layer of glass, and a backing sheet arranged alongside the decorative sheet on an opposite side from the glass assembly. An optional support structure is arranged alongside the backing sheet on an opposite side from the decorative sheet. The decorative sheet may be a wood veneer.Type: ApplicationFiled: March 20, 2015Publication date: September 22, 2016Inventors: Harold S. FRIEDMAN, Jeffrey M. FRIEDMAN, Viktor TSVIK
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Publication number: 20150141274Abstract: Disclosed herein are methods, compositions, and kits for isolating actively translated mRNA from heterogeneous cell populations. Also disclosed herein are methods, compositions, and kits for identifying cell types that respond to stimuli in heterogeneous cell populations.Type: ApplicationFiled: May 9, 2013Publication date: May 21, 2015Inventors: Jeffrey M. Friedman, Zachary A. Knight, Keith Tan, Kivan Birsoy
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Publication number: 20120208267Abstract: The present invention relates in general to microRNAs (miRNAs). More specifically, the invention relates to expression vectors comprising multiple miRNAs or families and, clusters capable of targeting multiple oncogenic pathways.Type: ApplicationFiled: November 14, 2011Publication date: August 16, 2012Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Jeffrey M. FRIEDMAN, Gangning LIANG, Peter A. JONES
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Patent number: 8173793Abstract: The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to nucleic acids encoding materials identified herein as modulators of weight. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i.e., synthetic or natural oligonucleotides.Type: GrantFiled: May 6, 2009Date of Patent: May 8, 2012Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Yiying Zhang, Ricardo Proenca, Margherita Maffei, Jeffrey L. Halaas, Ketan Gajiwala, Stephen K. Burley
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Publication number: 20110218332Abstract: The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question function as a hormone.Type: ApplicationFiled: May 6, 2009Publication date: September 8, 2011Inventors: Jeffrey M. Friedman, Yiying Zhang, Ricardo Proenca, Margherita Maffei, Jeffrey L. Halaas, Ketan Gajiwala, Stephen K. Burley
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Publication number: 20110201103Abstract: The present invention relates in general to microRNAs (miRNAs). More specifically, the invention relates to expression vectors comprising multiple miRNA families and clusters capable of targeting multiple oncogenic pathways.Type: ApplicationFiled: August 7, 2009Publication date: August 18, 2011Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Gangning Liang, Peter A. Jones, Jeffrey M. Friedman
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Patent number: 7994301Abstract: Modulators of weight, including, for example, two isoforms of murine and human ob polypeptides, are provided, as well as diagnostic and therapeutic uses and methods comprising such. Also provided are nucleotide sequences, degenerate variations thereof, and proteins expressed by such.Type: GrantFiled: April 21, 2009Date of Patent: August 9, 2011Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Yiying Zhang, Ricardo Proenca
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Patent number: 7812137Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.Type: GrantFiled: October 24, 2006Date of Patent: October 12, 2010Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca, Ella Ioffe
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Publication number: 20090318677Abstract: The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone.Type: ApplicationFiled: April 21, 2009Publication date: December 24, 2009Inventors: Jeffrey M. Friedman, Yiying Zhang, Ricardo Proenca
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Patent number: 7619079Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.Type: GrantFiled: April 24, 2006Date of Patent: November 17, 2009Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca
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Patent number: 7612171Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.Type: GrantFiled: March 16, 2006Date of Patent: November 3, 2009Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca
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Patent number: 7544492Abstract: The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone.Type: GrantFiled: August 10, 2000Date of Patent: June 9, 2009Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Jeffrey L. Halaas, Ketan Gajiwala, Stephen K. Burley
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Patent number: 7521258Abstract: Modulators of weight, including, for example, two isoforms of murine and human ob polypeptides, are provided, as well as diagnostic and therapeutic uses and methods comprising such. Also provided are nucleotide sequences, degenerate variations thereof, and proteins expressed by such. Such materials are useful, for example, as molecular probes, as primers for polymerase chain reaction (PCR) amplification, as well as for the generation of antibodies. Also provided are vectors comprising such nucleotide sequences, including bacterial, insect, and mammalian expression vectors, which nucleotide sequences are operatively associated with an expression control sequence. Cells transformed or transfected with such vectors, and the use of such in the preparation of disclosed modulators, are also provided.Type: GrantFiled: February 17, 2004Date of Patent: April 21, 2009Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Yiying Zhang, Ricardo Proenca
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Patent number: 7148004Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.Type: GrantFiled: January 16, 1997Date of Patent: December 12, 2006Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca, Ella Ioffe
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Patent number: 7084252Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.Type: GrantFiled: January 16, 1996Date of Patent: August 1, 2006Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca
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Patent number: 7063958Abstract: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.Type: GrantFiled: February 14, 1996Date of Patent: June 20, 2006Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Gwo-Hwa Lee, Ricardo Proenca
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Patent number: 6821945Abstract: The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and to diagnostic and therapeutic uses of such modulators. In its broadest aspect, the present invention relates to nucleotide sequences corresponding to the murine and human OB gene, and two isoforms thereof, and proteins expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight and that have been postulated to play a critical role in the regulation of body weight and adiposity. The present invention further provides nucleic acid molecules for use as molecular probes or as primers for polymerase chain reaction (PCR) amplification. In further aspects, the present invention provides cloning vectors and mammalian expression vectors comprising the nucleic acid molecules of the invention.Type: GrantFiled: October 10, 2000Date of Patent: November 23, 2004Assignee: The Rockefeller UniversityInventors: Jeffrey M. Friedman, Yiying Zhang, Ricardo Proenca