Patents by Inventor Jeffrey M. Linnen

Jeffrey M. Linnen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF WEST NILE VIRUS NUCLEIC ACIDS IN THE VIRAL 3' NON-CODING REGION
    Publication number: 20210040570
    Abstract: Compositions for detecting flavivirus nucleic acids are for detecting West Nile virus nucleic acids in the 3? non-coding region. The compositions can include oligonucleotides including nucleotide sequences that are substantially complementary to a West Nile virus target nucleic acid. The compositions can also include a detectable moiety.
    Type: Application
    Filed: August 18, 2020
    Publication date: February 11, 2021
    Inventors: Jeffrey M. LINNEN, Reinhold B. POLLNER
  • COMPOSITIONS AND METHODS FOR DETECTING ZIKA VIRUS NUCLEIC ACID
    Publication number: 20210010093
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: September 25, 2020
    Publication date: January 14, 2021
    Inventors: Kui GAO, Jeffrey M. LINNEN
  • COMPOSITIONS AND METHODS FOR DETECTING HEV NUCLEIC ACID
    Publication number: 20200399720
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: September 4, 2020
    Publication date: December 24, 2020
    Inventors: Kui GAO, Edgar O. ONG, Jennifer COLE, Jeffrey M. Linnen
  • Compositions and methods for detecting HEV nucleic acid
    Patent number: 10815541
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 27, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Edgar O. Ong, Jennifer Cole, Jeffrey M. Linnen
  • METHODS FOR ISOLATING A TARGET NUCLEIC ACID FROM RED BLOOD CELLS
    Publication number: 20200308661
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: May 8, 2020
    Publication date: October 1, 2020
    Inventors: Jijumon CHELLISERRY, Kui GAO, Jeffrey M. LINNEN
  • Detection of West Nile virus nucleic acids in the viral 3? non-coding region
    Patent number: 10781495
    Abstract: Compositions for detecting flavivirus nucleic acids. Particularly described are compositions for detecting West Nile virus nucleic acids in the 3? non-coding region. These compositions are preferably oligonucleotides comprising nucleotide sequences that are substantially complementary to a West Nile virus target nucleic acid. These compositions preferably comprise a detectable moiety.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: September 22, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jeffrey M. Linnen, Reinhold B. Pollner
  • Compositions and methods for detecting hepatitis B virus
    Patent number: 10745767
    Abstract: Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic acids.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: August 18, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jeffrey M. Linnen, Daniel P. Kolk, Janel M. Dockter, Damon K. Getman, Tadashi Yoshimura, Martha K. Ho-Sing-Loy, Reinhold B. Pollner, Leslie A. Stringfellow
  • Red blood cell lysis solution
    Patent number: 10689713
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: June 23, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jijumon Chelliserry, Kui Gao, Jeffrey M. Linnen
  • Compositions and Methods for Detecting or Quantifying Hepatitis B Virus
    Publication number: 20200063218
    Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.
    Type: Application
    Filed: November 1, 2019
    Publication date: February 27, 2020
    Applicant: Gen-Probe Incorporated
    Inventors: Kui Gao, Jeffrey M. Linnen
  • COMPOSITIONS AND METHODS FOR DETECTING ZIKA VIRUS NUCLEIC ACID
    Publication number: 20200040411
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: October 21, 2019
    Publication date: February 6, 2020
    Inventors: Kui GAO, Jeffrey M. LINNEN
  • Compositions and methods for detecting Zika virus nucleic acid
    Patent number: 10508312
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: December 17, 2019
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jeffrey M. Linnen
  • Compositions and methods for detecting or quantifying Hepatitis B virus
    Patent number: 10508313
    Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: December 17, 2019
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Jeffrey M. Linnen
  • METHOD FOR DETECTING CHIKUNGUNYA VIRUS
    Publication number: 20190367998
    Abstract: Compositions, methods and kits for detecting Chikungunya viral nucleic acids. Particularly described are methods for detecting very low levels of the viral nucleic acids using nucleic acid amplification.
    Type: Application
    Filed: June 3, 2019
    Publication date: December 5, 2019
    Inventors: James M. CARRICK, Jeffrey M. LINNEN
  • Method for detecting chikungunya virus
    Patent number: 10344341
    Abstract: Compositions, methods and kits for detecting Chikungunya viral nucleic acids. Particularly described are methods for detecting very low levels of the viral nucleic acids using nucleic acid amplification.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: July 9, 2019
    Assignee: GEN-PROBE INCORPORATED
    Inventors: James M. Carrick, Jeffrey M. Linnen
  • RED BLOOD CELL LYSIS SOLUTION
    Publication number: 20180334727
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Application
    Filed: June 27, 2018
    Publication date: November 22, 2018
    Inventors: Jijumon Chelliserry, Kui Gao, Jeffrey M. Linnen
  • COMPOSITIONS AND METHODS FOR DETECTING HEV NUCLEIC ACID
    Publication number: 20180334734
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: June 22, 2018
    Publication date: November 22, 2018
    Inventors: Kui Gao, Edgar O. Ong, Jennifer Cole, Jeffrey M. Linnen
  • Red blood cell lysis solution
    Patent number: 10093989
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: October 9, 2018
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jijumon Chelliserry, Kui Gao, Jeffrey M. Linnen
  • Compositions and methods for detecting HEV nucleic acid
    Patent number: 10053742
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: August 21, 2018
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Edgar O. Ong, Jennifer Cole, Jeffrey M. Linnen
  • Compositions and methods for detecting HEV nucleic acid
    Patent number: 10047406
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: August 14, 2018
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Kui Gao, Edgar O. Ong, Jennifer Cole, Jeffrey M. Linnen
  • COMPOSITIONS AND METHODS FOR DETECTING HEPATITIS B VIRUS
    Publication number: 20180195136
    Abstract: Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic acids.
    Type: Application
    Filed: January 25, 2018
    Publication date: July 12, 2018
    Inventors: Jeffrey M. LINNEN, Daniel P. KOLK, Janel M. DOCKTER, Damon K. GETMAN, Tadashi YOSHIMURA, Martha K. HO-SING-LOY, Reinhold B. POLLNER, Leslie A. STRINGFELLOW