Patents by Inventor Jeffrey M. Ralph

Jeffrey M. Ralph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical Compounds as ATF-4 Pathway Inhibitors
    Publication number: 20210093619
    Abstract: The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula IIIQ: wherein X6?, a, b, C8?, D8?, L82?, L83?, R81?, R82?, R83?, R84?, R85?, R86?, z82?, z84?, z85?, and z86? are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: June 7, 2018
    Publication date: April 1, 2021
    Inventors: Jeffrey Michael AXTEN, Michael P. DEMARTINO, Karen Anderson EVANS, Biswajit KALITA, Jeffrey M. RALPH
  • derivatives
    Patent number: 8895543
    Abstract: The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: November 25, 2014
    Assignee: Albany Molecular Research, Inc.
    Inventors: Ian L. Scott, Jeffrey M. Ralph, Matthew E. Voss
  • Benzene Sulfonamide Thiazole and Oxazole Compounds
    Publication number: 20140080851
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: November 25, 2013
    Publication date: March 20, 2014
    Applicant: GLAXOSMITHKLINE LLC
    Inventors: GEORGE ADJABENG, JERRY LEROY ADAMS, SCOTT HOWARD DICKERSON, KEITH HORNBERGER, NEIL W. JOHNSON, KEVIN KUNTZ, KIMBERLY PETROV, JEFFREY M. RALPH, TARA RENAE RHEAULT, GREGORY SCHAAF, JOHN STELLWAGEN, XINRONG TIAN, DAVID E. UEHLING, ALEX G. WATERSON, BRIAN WILSON
  • Benzene Sulfonamide Thiazole And Oxazole Compounds
    Publication number: 20130144055
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: January 31, 2013
    Publication date: June 6, 2013
    Applicant: GlaxoSmithKline LLC
    Inventors: George Adjabeng, Jerry Leroy Adams, Scott Howard Dickerson, Keith Hornberger, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David E. Uehling, Alex G. Waterson, Brian Wilson
  • Benzene sulfonamide thiazole and oxazole compounds
    Patent number: 8415345
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: April 9, 2013
    Assignee: Glaxo SmithKline LLC
    Inventors: George Adjabeng, Jerry Leroy Adams, Scott Howard Dickerson, Keith Hornberger, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David E. Uehling, Alex G. Waterson, Brian Wilson
  • Vinorelbine derivatives
    Patent number: 8053428
    Abstract: The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: November 8, 2011
    Assignee: Albany Molecular Research, Inc.
    Inventors: Ian L. Scott, Jeffrey M. Ralph, Matthew E. Voss
  • Benzene Sulfonamide Thiazole And Oxazole Compounds
    Publication number: 20110172215
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: May 4, 2009
    Publication date: July 14, 2011
    Inventors: George Adjabeng, Jeffrey Leroy Adams, Scott Howard Dickerson, Keith Hornberger, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David E. Uehling, Alex G. Waterson, Brian Wilson
  • Anthranilamide inhibitors of aurora kinase
    Patent number: 7884098
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: February 8, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H Faitg, Timothy Francis Gallagher, Neil W Johnson, Jiri Kasparec, Jeffrey M Ralph, Domingos J. Silva
  • Vinorelbine derivatives
    Patent number: 7842802
    Abstract: The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: November 30, 2010
    Assignee: Albany Molecular Research, Inc.
    Inventors: Ian L. Scott, Jeffrey M. Ralph, Matthew E. Voss
  • QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS
    Publication number: 20100234386
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
    Type: Application
    Filed: May 8, 2008
    Publication date: September 16, 2010
    Inventors: Amita Chaudhari, Dashyant Dhanak, Carla Ann Donatelli, Thomas H. Faitg, Yanhong Feng, Steven David Knight, Cynthia A. Parrish, Jeffrey M. Ralph, Martha A. Sarpong, Domingos J. Silva
  • Vinca derivatives
    Patent number: 7745619
    Abstract: The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 29, 2010
    Assignee: Albany Molecular Research, Inc.
    Inventors: Ian L. Scott, Jeffrey M. Ralph, Matthew E. Voss
  • ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
    Publication number: 20100016318
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Application
    Filed: January 25, 2008
    Publication date: January 21, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H. Faitg, Timothy Francis Gallagher, Neil W. Johnson, Jiri Kasparec, Jeffrey M. Ralph, Domingos J. Silva
  • Benzene Sulfonamide Thiazole and Oxazole Compounds
    Publication number: 20090298815
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: May 4, 2009
    Publication date: December 3, 2009
    Inventors: Jerry Leroy Adams, Scott Howard Dickerson, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David Edward Uehling, Alex Gregory Waterson, Brian Wilson
  • VINORELBINE DERIVATIVES
    Publication number: 20090088568
    Abstract: The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed.
    Type: Application
    Filed: December 10, 2008
    Publication date: April 2, 2009
    Applicant: AMR TECHNOLOGY, INC.
    Inventors: Ian L. Scott, Jeffrey M. Ralph, Matthew E. Voss
  • QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS
    Publication number: 20080293706
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
    Type: Application
    Filed: May 8, 2008
    Publication date: November 27, 2008
    Inventors: Amita CHAUDHARI, Dashyant DHANAK, Carla Ann DONATELLI, Thomas H. FAITG, Yanhong FENG, Steven David KNIGHT, Cynthia A. PARRISH, Jeffrey M. RALPH
  • Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases
    Publication number: 20080242667
    Abstract: The present invention provides a compound represented by Formula (I): or a salt thereof, or a solvate thereof, or a combination thereof, wherein the substituents are as defined herein. The present invention also relates to a composition comprising the compound of formula (I) and diluents, carriers, or excipients. Furthermore, the present invention relates to a method of treating a disease of cell proliferation comprising administering to a patient in need thereof a pharmaceutically effective amount of the compound of formula (I) or a salt thereof, or a solvate thereof, or a combination thereof.
    Type: Application
    Filed: August 23, 2006
    Publication date: October 2, 2008
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Jeffrey M. Ralph, Domingos J. Silva
  • Vinca derivatives
    Patent number: 7238704
    Abstract: The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: July 3, 2007
    Assignee: AMR Technology, Inc.
    Inventors: Ian L. Scott, Jeffrey M. Ralph, Matthew E. Voss
  • Vinorelbine derivatives
    Patent number: 7235564
    Abstract: The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: June 26, 2007
    Assignee: AMR Technology, Inc.
    Inventors: Ian L. Scott, Jeffrey M. Ralph, Matthew E. Voss