Abstract: A useful substance is extracted from botanical feedstock by mechanically compressing the feedstock and pumping a solvent through the compressed feedstock at high pressure while applying compressive mechanical force against the feedstock. Movement of pressurized solvent through the compressed feedstock may increase the volume of solvent in contact with the feedstock. Flow of solvent under pressure may also present a shearing force that facilitates dissociation of the useful substance from the feedstock.

Abstract: A useful substance is extracted from botanical feedstock by mechanically compressing the feedstock and pumping a solvent through the compressed feedstock at high pressure while applying compressive mechanical force against the feedstock. Movement of pressurized solvent through the compressed feedstock may increase the volume of solvent in contact with the feedstock. Flow of solvent under pressure may also present a shearing force that facilitates dissociation of the useful substance from the feedstock.

Abstract: An extraction system uses a sample of botanical matter which has been rendered into particles of a predetermined range of sizes and compressed into a non-flowable form. The sample is loaded into an extraction chamber which may be sealed. A conductive or convective heat source is used to heat the loaded sample to a temperature which causes at least one substance within the sample to vaporize. A conduit can be used to transfer vapor resulting from vaporization of the substance to a collection chamber and mask. Pressure may be adjusted within the system to facilitate vaporization and vapor transport.

Abstract: A useful substance is extracted from botanical feedstock by mechanically compressing the feedstock and pumping a solvent through the compressed feedstock at high pressure while applying compressive mechanical force against the feedstock. Movement of pressurized solvent through the compressed feedstock may increase the volume of solvent in contact with the feedstock. Flow of solvent under pressure may also present a shearing force that facilitates dissociation of the useful substance from the feedstock.

Abstract: Crystalline polymorphs of 1-ethyl-3,7-dihydro-8-[(1R,2R) -(hydroxycyclopentyl)amino]-3-(2-hydroxyethyl)-7-[(3-bromo-4-methoxyphenyl)methyl]-1H-Purine-2,6-dione in Form 1 and Form 2, which exhibit x-ray powder diffraction profiles substantially the same as those shown in FIGS. 5 and 6, respectively, and which exhibit differential scanning calorimtery profiles substantially the same as those shown in FIGS. 2 and 4, respectively, and are represented by the formula: Pharmaceutical compositions comprising the polymorph Form 1 or 2 of Compound 13 and at least one excipient or carrier, and methods of using the polymorph Form 1 or 2 of Compound 13 to treat a variety of physiological disorders, such as erectile dysfunction.

Abstract: Crystalline polymorphs of 1-ethyl-3,7-dihydro-8-[(1R,2R)-(hydroxycyclopentyl)amino]-3-(2-hydroxyethyl)-7-[(3-bromo-4-methoxyphenyl)methyl]-1H-Purine-2,6-dione in Form 1 and Form 2, which exhibit x-ray powder diffraction profiles substantially the same as those shown in FIGS. 5 and 6, respectively, and which exhibit differential scanning calorimtery profiles substantially the same as those shown in FIGS.