Abstract: An endoscopic tissue resection device configured to be attached at a distal tip of an endoscope is disclosed. The device comprises a cap, a snare sheath, a snare, and a spring wire. The snare comprises a collapsible snare wire configured to be retracted from the cavity of the cap into the snare sheath, the collapsible snare wire reversibly collapsing upon retraction, and to be advanced from the snare sheath into the cavity of the cap, the collapsible snare wire reversibly expanding upon advancement. The spring wire is reversibly deflectable from a resting state to a deflected state. In the resting state the spring wire orients and stabilizes an apex of the collapsible snare wire within the cap such that two opposing wire portions of the collapsible snare wire are positioned in apposition to a distal opening of the cap.

Abstract: A material restoration system for restoring material surfaces, the material restoration system comprising: a first composition including at least fifty percent alcohol by volume; at least twenty percent cutting oil by volume; denatured alcohol; C9-11 Pareth-8; Sodium C14-16; Sodium laureth sulfate; Sodium chloride; and Sodium xylenesulfonate.

Abstract: Captured samples of a physical structure or other scene are mapped to a predetermined multi-dimensional coordinate space, and spatially-adjacent samples are organized into array cells representing subspaces thereof. Each cell is classified according to predetermined target-identifying criteria for the samples of the cell. A cluster of spatially-contiguous cells of common classification, peripherally bounded by cells of different classification, is constructed, and a boundary demarcation is defined from the peripheral contour of the cluster. The boundary demarcation is overlaid upon a visual display of the physical scene, thereby visually demarcating the boundaries of a detected target of interest.

Abstract: A sole portion for an item of footwear having a plurality of cleat systems, cleats, or plate structures that dissipate force by deflecting, deforming, displacing or otherwise shifting under selected force, or by facilitating cleat movement around a radial line during ground engagement.

Abstract: In one embodiment, an operating system of a computing system determines, by an application instance manager of the operating system, that a first instance corresponding to a first application is to be activated according to an instance database managed by the operating system, where the first application includes several application components, including the first instance and a presenter. The application instance manager invokes the first instance and the presenter, the presenter being managed by the first instance. The operating system determines that the presenter is configured to present data obtained by a data provider, the data provider being one of several application components of a second application. The data provider accesses data from a data store and populates a dataset defined by the second application. The presenter of the first application generates a user interface to present the data from the dataset defined by the second application.

Abstract: The present disclosure relates to methods of administering Compound I for treating fibrotic disorders, inflammatory disorders or autoimmune disorders.

Abstract: The present invention provides methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators, and compositions having low impurity levels.

Abstract: A server system is communicatively connected to a plurality of computing devices and one or more databases. The server system receives one or more queries from a computing device. The one or more queries specify a data source. The server system determines a level of security applicable to a user of the computing device. The server system translates the one or more queries into one or more logical queries according to semantics of the data source, and transmits the logical queries to a query pipeline of the server system. The server system executes the one or more queries against a first database of the one or more databases to retrieve query results from the data source. The server system applies the determined level of security to the query results to obtain one or more data sets, and returns the one or more data sets to the computing device.

Abstract: The present invention provides crystalline forms of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same.

Abstract: Training a lexicon of a natural language processing system may include receiving a data set containing a corpus of absolute paths driven by a vehicle annotated with natural language descriptions of said absolute paths and determining parameters of the lexicon based on the data set. The degree to which a path taken by the vehicle satisfies the annotated description may be specified by a scoring function. The lexicon may be determined by finding the lexicon parameters that optimize the degree to which the paths taken by the vehicle satisfy the annotated descriptions. Objects in the environment of the same class are disambiguated by specifying their position relative to other objects using prepositions.

Abstract: Aspects of the present disclosure generally relate to systems and methods for flight control of aircrafts driven by electric propulsion systems and in other types of vehicles. In some embodiments, a flight control system of an aircraft is disclosed, configured to receive one or more signals to control movement of the aircraft, determine at least one flight condition of the aircraft, wherein the at least one flight condition includes at least a phase of flight, calculate at least one or more loads associated with the aircraft based on the determined at least one flight condition; determine an optimized flight configuration to alleviate loads on one or more components of the aircraft based on the received one or more signals and the calculated loads, generate one or more effector commands based on the optimized flight configuration; and actuate one or more aircraft effectors based on the one or more effector commands.

Abstract: In one embodiment, an operating system of a computing system determines, by an application instance manager of the operating system, that a first instance corresponding to a first application is to be activated according to an instance database managed by the operating system, where the first application includes several application components, including the first instance and a presenter. The application instance manager invokes the first instance and the presenter, the presenter being managed by the first instance. The operating system determines that the presenter is configured to present data obtained by a data provider, the data provider being one of several application components of a second application. The data provider accesses data from a data store and populates a dataset defined by the second application. The presenter of the first application generates a user interface to present the data from the dataset defined by the second application.

Abstract: Vacuum-integrated photoresist-less methods and apparatuses for forming metal hardmasks can provide sub-30 nm patterning resolution. A metal-containing (e.g., metal salt or organometallic compound) film that is sensitive to a patterning agent is deposited on a semiconductor substrate. The metal-containing film is then patterned directly (i.e., without the use of a photoresist) by exposure to the patterning agent in a vacuum ambient to form the metal mask. For example, the metal-containing film is photosensitive and the patterning is conducted using sub-30 nm wavelength optical lithography, such as EUV lithography.

Abstract: A system and method which allows the basic checkpoint-reverse-mode AD strategy (of recursively decomposing the computation to reduce storage requirements of reverse-mode AD) to be applied to arbitrary programs: not just programs consisting of loops, but programs with arbitrarily complex control flow. The method comprises (a) transforming the program into a formalism that allows convenient manipulation by formal tools, and (b) introducing a set of operators to allow computations to be decomposed by running them for a given period of time then pausing them, while treating the paused program as a value subject to manipulation.

Abstract: Certain embodiments provide a method of providing added peripheral IDS activity to a subject with Hunter syndrome, comprising administering to the subject a therapeutically effective dose of a pharmaceutical composition comprising a protein comprising an IDS amino acid sequence and a TfR binding domain. The added peripheral IDS activity can be measured by comparing levels of keratan sulfate (KS) in the subject after administration of the pharmaceutical composition relative to a baseline level. Certain embodiments also provide methods of providing a clinical benefit to a subject with Hunter syndrome and improving treatment in a patient having non-neuronopathic Hunter syndrome, as well as methods and treatment regimens for resolving infusion related reactions (IRRs).

Abstract: The present invention provides methods of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators, methods of preparing intermediates of pyrimidine cyclohexyl glucocorticoid receptor modulators, and pyridinium compounds.

Abstract: A computing device generates and displays a data visualization in a data visualization user interface. The data visualization includes a plurality of visual data marks representing data from a data source. The computing device detects a first user input to select a visual data mark of the plurality of visual data marks. In response to detecting the first user input, the computing device identifies a first aggregated data value, for the visual data mark, corresponding to a first data field in the data source. The computing device retrieves a first disaggregated set of data rows corresponding to the first aggregated data value, from a first table, in the data source, containing the first data field. The computing device displays, in the data visualization user interface, a plurality of data rows from the first disaggregated set of data rows.

Abstract: The present invention provides methods of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators, methods of preparing intermediates of pyrimidine cyclohexyl glucocorticoid receptor modulators, and thioether compounds.

Abstract: A data signal receiver circuit, including: a comparator configured to generate a first data signal based on a comparison of an input data signal and a reference voltage, wherein the first data signal includes a first logic low pulse and a first logic high pulse; and a duty cycle control circuit configured to generate: a second data signal based on the first data signal, wherein the second data signal includes a second logic low pulse responsive to the first logic low pulse, wherein the second logic low pulse has a width greater than a unit interval (UI); and a third data signal based on the first data signal, wherein the third data signal includes a second logic high pulse responsive to the first logic high pulse, wherein the second logic high pulse has a width greater than the UL.

Abstract: A client device receives one or more inputs for generating a data visualization according to a data source. The device determines one or more requirements for generating the data visualization. The device sends a request to a network gateway that is communicatively connected to the client device and a plurality of data servers, and receives, from the network gateway, capabilities of each data server. The device determines, according to the received capabilities, that a first data server of the plurality of data servers includes a first set of capabilities that satisfies the requirements for generating the data visualization. The device sends, via the network gateway, one or more queries to the first data server and receives, from the first data server, one or more data sets from the data source. The device generates the data visualization according to the retrieved data sets and displays the data visualization.