Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:

Abstract: The present disclosure provides, inter alia, methods of treating generalized pustular psoriasis (GPP) by administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C—X—C motif chemokine receptor 2 (CXCR2) antagonist. Also provided herein are methods of modulating dysregulated IL-36 signaling in a subject in need thereof and methods of reducing neutrophil, inflammatory dendritic cell (iDC), and/or CD4 T cell accumulation in a subject in need thereof, said methods, include administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C—X—C motif chemokine receptor 2 (CXCR2) antagonist.

Abstract: Compounds are provided as chemokine inhibitors having the structure:

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein Z, L, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:

Abstract: Compounds are provided as chemokine inhibitors having the structure:

Abstract: Compounds are provided as chemokine inhibitors having the structure:

Abstract: Embodiments relate to managing exclusive control of a shareable resource between a plurality of concurrently executing threads. An aspect includes determining the number of concurrently executing threads waiting for exclusive control of the shareable resource. Another aspect includes, responsive to a determination that the number of concurrently executing threads waiting for exclusive control of the shareable resource exceeds a pre-determined value, one or more of said concurrently executing threads terminating its wait for exclusive control of the shareable resource. Another aspect includes, responsive to a determination that the number of concurrently executing threads waiting for exclusive control of the shareable resource is less than a pre-determined value, one or more of said one or more concurrently executing threads which terminated its wait for exclusive control of the shareable resource, restarting a wait for exclusive control of the shareable resource.

Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:

Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:

Abstract: Compounds are provided as chemokine inhibitors having the structure:

Abstract: Embodiments relate to managing exclusive control of a shareable resource between a plurality of concurrently executing threads. An aspect includes determining the number of concurrently executing threads waiting for exclusive control of the shareable resource. Another aspect includes, responsive to a determination that the number of concurrently executing threads waiting for exclusive control of the shareable resource exceeds a pre-determined value, one or more of said concurrently executing threads terminating its wait for exclusive control of the shareable resource. Another aspect includes, responsive to a determination that the number of concurrently executing threads waiting for exclusive control of the shareable resource is less than a pre-determined value, one or more of said one or more concurrently executing threads which terminated its wait for exclusive control of the shareable resource, restarting a wait for exclusive control of the shareable resource.

Abstract: A dry food waste disposal system has a food waste disposer having a grind and discharge section having a grind mechanism having a stationary grind ring and a rotatable shredder plate rotated by a motor. The dry food waste disposal system also includes a storage tank that includes a sensor that senses how full the storage tank is, a discharge line coupling a discharge outlet of the food waste disposer to the storage tank, and a controller that disables the food waste disposer off in response to the sensor sensing that the storage tank is full.