Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: A method including: obtaining a detected representation of radiation redirected by each of a plurality of structures from a substrate additionally having a device pattern thereon, wherein each structure has an intentional different physical configuration of the respective structure than the respective nominal physical configuration of the respective structure, wherein each structure has geometric symmetry at the respective nominal physical configuration, wherein the intentional different physical configuration of the structure causes an asymmetric optical characteristic distribution and wherein a patterning process parameter measures change in the physical configuration; and determining a value, based on the detected representations and based on the intentional different physical configurations, to setup, monitor or correct a measurement recipe for determining the patterning process parameter.

Abstract: A method for developing software as a layered, segmented system having diverse functionalities, based on a software architecture and an aerial vehicle utilizing the software architecture are provided. The software architecture for the aerial vehicle, such as an unmanned aerial vehicle (UAV) includes an electrical segment, a propulsion segment, a flight management segment, a navigation segment, a data link segment, and perhaps a payload segment. Each segment includes a number of software modules and objects, and each segment interfaces with or controls one or more devices. The software architecture also includes a number of layers, including an executive layer for managing execution rates of the segments, a vehicle controller layer for coordinating activities across segments, and various layers providing utilities, common services, and computing support including operating system support. Rules of engagement guiding interaction between software entities within the software architecture are specified.

Abstract: A method for developing software as a layered, segmented system having diverse functionalities, based on a software architecture and an aerial vehicle utilizing the software architecture are provided. The software architecture for the aerial vehicle, such as an unmanned aerial vehicle (UAV) includes an electrical segment, a propulsion segment, a flight management segment, a navigation segment, a data link segment, and perhaps a payload segment. Each segment includes a number of software modules and objects, and each segment interfaces with or controls one or more devices. The software architecture also includes a number of layers, including an executive layer for managing execution rates of the segments, a vehicle controller layer for coordinating activities across segments, and various layers providing utilities, common services, and computing support including operating system support. Rules of engagement guiding interaction between software entities within the software architecture are specified.