Abstract: An electronic device detects a contact on a touch-sensitive surface of the electronic device, including a first portion of a gesture made with the contact, a second portion of the gesture that follows the first portion, and lift-off of the contact from the touch-sensitive surface during or after the second portion of the gesture. In response to detecting the second portion of the gesture, if a modifier input was detected while detecting the first portion of the gesture made with the contact, the electronic device performs a first operation and generates a first tactile output on the touch-sensitive surface. If the modifier input was not detected while detecting the first portion of the gesture, the electronic device performs a second operation different from the first operation and generates a second tactile output on the touch-sensitive surface, wherein the second tactile output is different from the first tactile output.

Abstract: A device for online gaming includes an actuation component and a controller communicatively coupled to a computer system. The controller is configured to perform operations including detecting an actuation of the actuation component, wherein the actuation component is associated with performing of an action in a video game executed by the computer system. Responsive to detecting the actuation, an instruction is provided to the computer system to perform the action, wherein, based on a current value of a timer, the computer system restricts the action from being performed. The timer, having been previously initiated based on a prior actuation of the actuation component, relates to a cooldown period during which the action cannot be repeated after the action is performed. Responsive to receiving a command from the computer system, a tactile effect is generated as an indication to a user that the action can be repeated.

Abstract: Systems and methods for generating a video of a user-defined virtual reality scene are disclosed. Exemplary implementations may: obtain a scene definition; obtain camera information for multiple virtual cameras to be used in generating a two-dimensional presentation of the virtual reality scene; execute a simulation of the virtual reality scene from the scene definition for at least a portion of the scene duration; obtain camera timing instructions specifying which of the virtual cameras should be used to generate the two-dimensional presentation of the virtual reality scene as a function of progress through the scene duration; generate the two-dimensional presentation of the virtual reality scene in accordance with the camera timing instructions and the camera information.

Abstract: A device includes a lower reservoir surface, an upper reservoir surface, and a reservoir sidewall extending between the upper and lower reservoir surfaces which together define a reservoir. The reservoir is configured to be completely filled by a liquid such that the liquid forms a column contacting the upper reservoir surface, the lower reservoir surface, and the reservoir sidewall, with a meniscus of the liquid being outside of the reservoir. At least one of the upper reservoir surface and the lower reservoir surface is configured to transmit light.

Abstract: A system for genetic editing of a transthyretin (TTR) gene, comprising (i) a Cas12i2 polypeptide or a first nucleic acid encoding the Cas12i2 polypeptide, and (ii) an RNA guide or a second nucleic acid encoding the RNA guide, wherein the RNA guide comprises a spacer sequence specific to a target sequence within an TTR gene. Also provided herein are methods for editing a TTR gene using the gene editing system disclosed herein and/or for treating diseases associated with the TTR gene.

Abstract: Fibrous structures having a surface pattern of a continuous knuckle region and a plurality of discrete pillow regions such that the fibrous structures exhibit improved softness compared to known fibrous structures and better sheet control during the making of such fibrous structures are provided.

Abstract: A computer implemented method of reducing data elements in a data file includes: receiving a data file including one or more primary data elements; storing the data file in a memory coupled to the processor; generating, from at least one of the one or more primary data elements, a plurality of supplemental data elements; determining whether any of the plurality of supplemental data elements and any of the primary data elements offset each other; and upon determining that at least one of the plurality of supplemental data elements and at least one of the primary data elements offset each other, deleting, from the data file, at least one of the offset supplemental data elements or primary data elements.

Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting HAO1 for use in genetic editing of the HAO1 gene. Also provide herein are methods of using the gene editing system for introducing edits to the HAO1 gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.

Abstract: Disclosed herein are transdermal microneedling devices that generate and emit low RF energy. Such a microneedling device may comprise a drive motor, drive circuitry for controlling the drive motor, and a drive linkage located on the drive motor rotor. The microneedling device may also comprise a power source capsule comprising a battery and associated power management circuitry. Also included may be a needle cartridge coupled to the main body, and comprising a drive shaft and a needle unit coupled to a distal end of the drive shaft to move therewith, where the needle unit has at least one needle extending therefrom. The drive shaft may comprise a linkage member configured to engage the drive linkage of the drive motor, and be configured to be driven by the drive motor and thereby drive movement of the needle unit such that the at least one needle extends beyond and retracts within the distal end of the needle cartridge.

Abstract: A method, computer readable medium, and processor are described herein for inline data inspection by using a decoder to decode a load instruction, including a signal to cause a circuit in a processor to indicate whether data loaded by a load instruction exceeds a threshold value. Moreover, an indication of whether data loaded by a load instruction exceeds a threshold value may be stored.

Abstract: An inhalation device (10), in particular an electronic cigarette, has at least one liquid jet device (24), such as a micro heater or resistor, to produce liquid drops on demand, wherein a hollow needle (40) is mounted on the liquid jet device (24). A cartridge (16) has at least one first septum (54) sealing Around the needle (40) of the inhalation device (10). Further, the invention relates to a method of conveying liquid drops in an inhalation device (10) as a liquid jet, such as by means of at least one liquid jet device (24), in particular a micro heater or resistor, in combination with a hollow needle (40) mounted on the liquid jet device (24).

Abstract: An inner mandrel for forming a variable taper component includes a plurality of interlocking pieces and a brace. Each interlocking piece defines opposed tapered edge faces, a first surface, and a tapered second surface opposite the first surface. One of the edge faces defines a locking feature and another of the edge faces defines a receiving feature engaging the locking feature of an adjacent interlocking piece. The first surface defines a variable taper and a plurality of recesses. The brace secures the plurality of interlocking pieces to each other in a concentric arrangement about a central axis. A maximum width of each of the interlocking pieces is smaller than a minimum width of an end portion of the variable taper component. A central portion of the variable taper component is wider than the end portions.

Abstract: This invention provides a polymer, which is preferably a polyether polymer. The polymer may be used in coating compositions. Containers and other articles comprising the polymer and methods of making such containers and other articles are also provided. The invention further provides compositions including the polymer (e.g., powder coatings), which have utility in a variety of coating end uses, including, for example, valve and pipe coatings.

Abstract: Disclosed adjustable retaining arm systems can include a multi-segmented, articulable arm that holds one or more interchangeable tools and can be made relaxed to set a desired position and made rigid to fix the desired position by adjusting tension in a cable running through the arm. The arm can quickly attach and detach from a support structure. The support structure include a cable tensioning system, sensors, control system, power system, etc. A user input device, such as a foot pedal or button on the arm, can be used by a surgeon to change the arm between relaxed and rigid states. The arm and attachable tools can be detachable, disposable and/or sterilizable, while other system components can remain mounted in a fixed location as the arm is removed and replaced. The arm can hold multiple tools in any desired orientation around subject work location.

Abstract: Embodiments of the present disclosure relate to techniques for accurate positioning of an energy application device for neuromodulation treatment protocols. In one embodiment, a neuromodulation positioning patch is applied to a patient's skin. The energy application device is configured to couple to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. In one embodiment, the frame is also configured to couple to a removable dock for an imaging probe that, when coupled to the removable dock and, in turn, the frame of the neuromodulation positioning patch, is configured to acquire image data through the opening to identify or verify a treatment position.

Abstract: A water heating system is disclosed. The water heating system may include a water tank configured to store water, a heating element configured to heat the water inside the water tank, and a sensor configured to measure water temperature in the water tank. The water heating system may further include a controller configured to determine a difference between a target water temperature and the water temperature. The controller may activate the heating element when the determined difference is greater than a differential temperature threshold value. The controller may be further configured to detect a trigger event, and decrease the differential temperature threshold value from a first value to a second value responsive to detecting the trigger event.

Abstract: An event detection system in a telecommunications network is coupled to base stations to receive characteristics of uplink network traffic transmitted to the base stations. The event detection system identifies a geographic area in which the one or more characteristics of a subset of the uplink network traffic, generated by electronic devices located within the identified geographic area, satisfy a criterion. An event indicator is generated based on the subset of uplink network traffic. The event indicator can then be used by the event detection system, another component of the telecommunications network, or an external system to provide an event-based service that leverages information about events to provide information or content to people participating in or nearby to an event.

Abstract: An event indicator is received from an event detection system in a data network. The event indicator identifies a geographic area in which characteristics of uplink network traffic, generated by electronic devices located within the identified geographic area, satisfy a criterion. One or more media content items that were generated by respective electronic devices located within the identified geographic area are identified. Each media content item is mapped to a respective location within the identified geographic area based on a location of the respective electronic device that generated the media content item. A first media content item is output to an emergency response system based on the location to which the first media content item is mapped.

Abstract: A debris collection assembly includes a jig and an adapter insert. The jig includes a front wall and a back wall opposite the front wall. The front wall defines an aperture therethrough. The back wall defines an adapter opening that aligns with the aperture. The jig includes a vacuum port and defines an interior cavity that fluidly connects the aperture, the adapter opening, and the vacuum port. The adapter insert is removably loaded through the adapter opening into the interior cavity of the jig. The adapter insert defines an orifice sized to receive a drill bit and allow the drill bit to extend through the aperture in the front wall to drill into a work piece. Negative pressure at the vacuum port draws airflow through the interior cavity and captures debris generated from drilling.