Patents by Inventor Jeffrey Mintzes
Jeffrey Mintzes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120107241Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: August 29, 2011Publication date: May 3, 2012Inventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Patent number: 7628977Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: GrantFiled: April 18, 2003Date of Patent: December 8, 2009Assignees: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Patent number: 7469488Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: GrantFiled: October 29, 2004Date of Patent: December 30, 2008Assignees: Alkermes, Inc., The Penn State Research FoundationInventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
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Publication number: 20080253971Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: April 18, 2003Publication date: October 16, 2008Applicants: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: David Edwards, Robert Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Publication number: 20070014738Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: September 20, 2006Publication date: January 18, 2007Inventors: David Edwards, Robert Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Patent number: 7052678Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a polycationic complexing agent which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the polycationic complexing agent upon association with the bioactive agent. The particles can further comprise a pharmaceutically acceptable carrier. The amount of polycationic complexing agent present in the particles is an amount sufficient to sustain the release of diagnostic, therapeutic or prophylactic agent from the particles.Type: GrantFiled: March 7, 2002Date of Patent: May 30, 2006Assignees: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: Rita Vanbever, Robert S. Langer, David A. Edwards, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Publication number: 20060039987Abstract: Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.Type: ApplicationFiled: October 24, 2005Publication date: February 23, 2006Applicant: Advanced Inhalation Research, Inc.Inventors: Richard Batycky, Blair Jackson, Lloyd Johnston, Jeffrey Mintzes, Ernest Penachio
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Publication number: 20050163725Abstract: The claimed invention relates to a method of treating a human patient with growth hormone deficiency or a non-growth hormone deficiency disorder treatable with hGH, which comprises administering human growth hormone to the deep lung to said patient by a pulmonary device.Type: ApplicationFiled: July 28, 2004Publication date: July 28, 2005Inventors: Charles Blizzard, John Chipman, Gordon Cutler, Blair Jackson, Lloyd Johnston, Richard Lucas, Jeffrey Mintzes
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Publication number: 20050058607Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: ApplicationFiled: October 29, 2004Publication date: March 17, 2005Applicants: Avanced Inhalation Research, Inc., The Penn State Research FoundationInventors: Donghao Chen, Richard Batycky, LIoyd Johnson, Jeffrey Mintzes
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Patent number: 6848197Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: GrantFiled: April 18, 2001Date of Patent: February 1, 2005Assignees: Advanced Inhalation Research, Inc., The Penn State Research Foundation, Inc.Inventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
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Publication number: 20040062718Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: April 18, 2003Publication date: April 1, 2004Applicants: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Publication number: 20040009231Abstract: This invention relates to the administration of proteins by absorption from the lungs. In particular, it is concerned with providing therapeutic doses of human growth hormone to the bloodstream without irritating or otherwise damaging lung tissue. This invention also relates to the methods of delivery of human growth hormone to the pulmonary system.Type: ApplicationFiled: March 19, 2003Publication date: January 15, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: Blair Jackson, Lloyd Johnston, Charles D. Blizzard, Jeffrey Mintzes
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Patent number: 6652837Abstract: Particles incorporating a surfactant and/or a hydrophilic or hydrophobic complex of a positively or negatively charged therapeutic agent and a charged molecule of opposite charge for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 &mgr;m and 30 &mgr;m, which together yield an aerodynamic diameter of the particles of between approximately one and three microns. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of poly(lactic acid) or poly(glycolic acid) or copolymers thereof. Alternatively, the particles may be formed solely of a therapeutic or diagnostic agent and a surfactant.Type: GrantFiled: September 13, 1999Date of Patent: November 25, 2003Assignees: Massachusetts Institute of Technology, The Penn State Research FoundationInventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Publication number: 20030068277Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a polycationic complexing agent which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the polycationic complexing agent upon association with the bioactive agent. The particles can further comprise a pharmaceutically acceptable carrier. The amount of polycationic complexing agent present in the particles is an amount sufficient to sustain the release of diagnostic, therapeutic or prophylactic agent from the particles.Type: ApplicationFiled: March 7, 2002Publication date: April 10, 2003Applicant: Massachusetts Institute of TechnologyInventors: Rita Vanbever, Robert S. Langer, David A. Edwards, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Publication number: 20030017113Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: ApplicationFiled: April 18, 2001Publication date: January 23, 2003Applicant: Advanced Inhalation Research, Inc.Inventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
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Publication number: 20020052310Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.Type: ApplicationFiled: December 29, 2000Publication date: May 2, 2002Applicant: Massachusetts Institute of Technology The Penn State Research FoundationInventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen
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Patent number: 5985309Abstract: Particles incorporating a surfactant and/or a hydrophilic or hydrophobic complex of a positively or negatively charged therapeutic agent and a charged molecule of opposite charge for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and a mass mean diameter between 5 .mu.m and 30 .mu.m, which together yield an aerodynamic diameter of the particles of between approximately one and three microns. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of poly(lactic acid) or poly(glycolic acid) or copolymers thereof. Alternatively, the particles may be formed solely of a therapeutic or diagnostic agent and a surfactant.Type: GrantFiled: November 17, 1997Date of Patent: November 16, 1999Assignee: Massachusetts Institute of TechnologyInventors: David A. Edwards, Robert S. Langer, Rita Vanbever, Jeffrey Mintzes, Jue Wang, Donghao Chen