Patents by Inventor Jeffrey Mohr

Jeffrey Mohr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080026460
    Abstract: A three-dimensional microwell system that supports long term embryonic stem cell (ESCs) culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured ESCs remain viable and undifferentiated for several weeks in culture and maintain undifferentiated replication when passaged to Matrigel®-coated, tissue culture-treated polystyrene dishes. Microwell-cultured ESCs maintain pluripotency, differentiating to each of the three embryonic germ layers. ESC aggregates released from microwells can be passaged for undifferentiated replication or differentiated to monodisperse EBs. The ability to constrain ESC growth in three dimensions advantageously provides for more efficient, reproducible culture of undifferentiated cells, high-throughput screening, and the ability to direct ESC differentiation by generating monodisperse EBs of a desired size and shape.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 31, 2008
    Inventors: Sean Palecek, Jeffrey Mohr, Juan De Pablo
  • Publication number: 20070269848
    Abstract: The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.
    Type: Application
    Filed: November 30, 2006
    Publication date: November 22, 2007
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Nicholas Abbott, Jeffrey Mohr, Christopher Murphy, Elise Huang, Juan De Pablo, Sean Palecek, Nathan Lockwood