Publication number: 20250140413
Abstract: A method of treating preterm birth (PTB) risk in a subject is disclosed. An example method may obtain risk indicator values for two or more risk indicators selected from a panel of risk indicators comprising the group consisting of: AFP, anemia status, assistance status, body mass index, CD40L, cholesterol, CRP, diabetes status, ENA78, EOTAXIN, GP130, hCG, HDL, HGF, hypertension status, ICAM1, IFNA, IFNB, IL-10, IL-13, Il-15, IL-1A, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-8, IL1R1, IL4R, INH, IP-10, LDL, LIF, MCP3, MCSF, MIG, MIP1A, MIP1B, NGF, PAPP-A, parity, PDGFBB, progesterone, RANTES, ratio of triglycerides to HDL, sFASL, TNFR1, TRAIL, triglycerides, VEGF, VEGFR1, VEGFR2, and VEGFR3. The example method may input the obtained risk indicator values into a predictive model to calculate a predictive score indicative of PTB risk, determine the subject has an elevated risk of PTB risk based upon the predictive score, and administer an intervention to the subject.
Type:
Application
Filed:
October 31, 2024
Publication date:
May 1, 2025
Inventors:
Laura Jelliffe, Kelli Ryckman, Jeffrey Murray