Abstract: The present disclosure relates to the design, fabrication, and applications of a three-dimensional (3D) bioreactor for cell expansion and cell secreted substance production. The bioreactor is composed of non-random interconnected voids providing a continuous three-dimensional surface area for cell adherence and growth.

Abstract: The present disclosure relates to the design, fabrication, and applications of a three-dimensional (3D) bioreactor for cell expansion and cell secreted substance production. The bioreactor is composed of non-random interconnected voids providing a continuous three-dimensional surface area for cell adherence and growth.

Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disks 17a and spacers (33, 40) are stacked to form a disk stack 17 having a feed well 31 in the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well 31. The fluid then flows into spacer channels (37, 41) within or on the surface of the spacers. The channels (37, 41) communicate the fluid toward the outer edges of the disks 17a. The disk surface past the spacers (33, 40) can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of patterned disks are stacked to form a disk stack having a feed well in the center core of the stack. Each patterned disk has channels defined by spacers, with the channels and spacers being of varying depths, heights, and/or widths. The fluid to be atomized or encapsulated is delivered to the feed well. The fluid then flows into the channels, which communicate the fluid toward the outer edges of the disks. The fluid exits the disk stack from a circumferential gap, which is created by interposing spacing disks between the patterned disks.

Abstract: An optoacoustic probe for optoacoustic imaging of a tissue is provided. The probe has a distal end operable to contact the tissue and a proximal end. A transducer assembly is configured to receive optoacoustic return signals. An optical window is configured to carry light along a light path to the tissue. The housing comprises a distal portion that has a probe face that includes an acoustic opening into which the transducer assembly is disposed and an optical opening into which the optical window is disposed. The transducer assembly and the optical window extend proximally from the probe face. A gasket is disposed within the optical opening at the probe face and extends at least partially around the optical window. The gasket is configured to form an optoacoustic barrier to at least partially optically and acoustically isolate at least a portion of the optical window from the housing of the probe.

Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disks 17a and spacers (33, 40) are stacked to form a disk stack 17 having a feed well 31 in the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well 31. The fluid then flows into spacer channels (37, 41) within or on the surface of the spacers. The channels (37, 41) communicate the fluid toward the outer edges of the disks 17a. The disk surface past the spacers (33, 40) can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of patterned disks are stacked to form a disk stack having a feed well in the center core of the stack. Each patterned disk has channels defined by spacers, with the channels and spacers being of varying depths, heights, and/or widths. The fluid to be atomized or encapsulated is delivered to the feed well. The fluid then flows into the channels, which communicate the fluid toward the outer edges of the disks. The fluid exits the disk stack from a circumferential gap, which is created by interposing spacing disks between the patterned disks.

Abstract: The present disclosure relates to the design, fabrication, and applications of a three-dimensional (3D) bioreactor for cell expansion and cell secreted substance production. The bioreactor is composed of non-random interconnected voids providing a continuous three-dimensional surface area for cell adherence and growth.

Abstract: The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.

Abstract: A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 ?m to 600 ?m. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.

Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disks 17a and spacers (33, 40) are stacked to form a disk stack 17 having a feed well 31 in the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well 31. The fluid then flows into spacer channels (37, 41) within or on the surface of the spacers. The channels (37, 41) communicate the fluid toward the outer edges of the disks 17a. The disk surface past the spacers (33, 40) can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

Abstract: The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.

Abstract: The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.

Abstract: A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 ?m to 600 ?m. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.

Abstract: A selective non-catalytic reduction apparatus for exhaust gases comprising a reactor for elevated temperature reduction of NOx comprising an injection zone, internal structure zone and rear zone. The internal structure zone includes packing materials and provides a surface area of 5.0 m2/g to 20 m2/g where the packing material is present in the reactor at a level of 10% to 50% of the reactor volume. The reactor provides one or more of the following: (1) a residence time for exhaust gas of 0.1 seconds to 5.0 seconds; (2) a pressure drop of less than or equal to 1400 Pa/m at an exhaust gas velocity of 1.0 meter/second.

Abstract: The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.