Patents by Inventor Jeffrey N. Johnston

Jeffrey N. Johnston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Verticilide enantiomer and methods of inhibiting cardiac ryanodine receptor-mediated intracellular calcium release
    Patent number: 11208435
    Abstract: The non-natural enantiomer (ent-(+)-verticilide) and uses for treatment of RyR2-mediated spontaneous Ca2+ leak, arrhythmia and memory loss.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: December 28, 2021
    Assignee: Vanderbilt University
    Inventors: Jeffrey N. Johnston, Suzanne Batiste, Bjorn C. Knollmann, Daniel J Blackwell, Nieves Gomez-Hurtado
  • VERTICILIDE ENANTIOMER AND METHODS OF INHIBITING CARDIAC RYANODINE RECEPTOR-MEDIATED INTRACELLULAR CALCIUM RELEASE
    Publication number: 20200262872
    Abstract: The non-natural enantiomer (ent-(+)-verticilide) and uses for treatment of RyR2-mediated spontaneous Ca2+ leak, arrhythmia and memory loss.
    Type: Application
    Filed: June 25, 2018
    Publication date: August 20, 2020
    Inventors: Jeffrey N. Johnston, Suzanne Batiste, Bjorn C. Knollmann, Daniel J Blackwell, Nieves Gomez-Hurtado
  • Stereoselective methods, catalysts and intermediates for the synthesis of (?)-Nutlin-3 and related compounds
    Patent number: 8889863
    Abstract: The present invention provides methods and intermediates are provided for the preparation of (?)-Nutlin-3. Methods and intermediates are also provided for the enantioselective addition of aryl nitromethanes to aldimines. Bis(amidine) catalysts for the use in these and other reactions are also provided.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: November 18, 2014
    Assignee: Vanderbilt University
    Inventors: Jeffrey N. Johnston, Tyler A. Davis
  • STEREOSELECTIVE METHODS, CATALYSTS AND INTERMEDIATES FOR THE SYNTHESIS OF (-)-NUTLIN-3 AND RELATED COMPOUNDS
    Publication number: 20120088915
    Abstract: The present invention provides methods and intermediates are provided for the preparation of (?)-Nutlin-3. Methods and intermediates are also provided for the enantioselective addition of aryl nitromethanes to aldimines. Bis(amidine) catalysts for the use in these and other reactions are also provided.
    Type: Application
    Filed: July 14, 2011
    Publication date: April 12, 2012
    Inventors: Jeffrey N. Johnston, Tyler A. Davis
  • Amination process
    Patent number: 7078567
    Abstract: The present invention provides methodology for carbon-nitrogen bond formation via vinyl or aryl amination. In the process of the invention, an sp2 hybridized radical is reacted with an azomethine moiety to form pyrrolidine and indole compounds. The methodology provides a facile process for the synthesis of compounds having the pyrrolidine or indole subunit and is especially advantageous for compounds having acid or base labile functional groups and/or is comprised of chiral centers susceptible to acid/base epimerization.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: July 18, 2006
    Inventors: Jeffrey N. Johnston, Rajesh Viswanathan
  • Chiral organic compounds and metal coordination complexes thereof
    Patent number: 6943256
    Abstract: Disclosed are chiral organic compounds and metal coordination complexes thereof having C2 symmetry.
    Type: Grant
    Filed: October 20, 2003
    Date of Patent: September 13, 2005
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Jeffrey N. Johnston
  • Chiral organic compounds and metal coordination complexes thereof
    Publication number: 20040143118
    Abstract: Disclosed are chiral organic compounds and metal coordination complexes thereof having C2 symmetry.
    Type: Application
    Filed: October 20, 2003
    Publication date: July 22, 2004
    Inventor: Jeffrey N. Johnston
  • Amination process
    Publication number: 20040082778
    Abstract: The present invention provides methodology for carbon-nitrogen bond formation via vinyl or aryl amination. In the process of the invention, an sp2 hybridized radical is reacted with an azomethine moiety to form pyrrolidine and indole compounds. The methodology provides a facile process for the synthesis of compounds having the pyrrolidine or indole subunit and is especially advantageous for compounds having acid or base labile functional groups and/or is comprised of chiral centers susceptible to acid/base epimerization.
    Type: Application
    Filed: October 16, 2003
    Publication date: April 29, 2004
    Inventors: Jeffrey N. Johnston, Rajesh Viswanathan
  • Amination process
    Patent number: 6670479
    Abstract: The present invention provides methodology for carbon-nitrogen bond formation via vinyl or aryl amination. In the process of the invention, an sp2 hybridized radical is reacted with an azomethine moiety to form pyrrolidine and indole compounds. The methodology provides a facile process for the synthesis of compounds having the pyrrolidine or indole subunit and is especially advantageous for compounds having acid or base labile functional groups and/or is comprised of chiral centers susceptible to acid/base epimerization.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: December 30, 2003
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventors: Jeffrey N. Johnston, Rajesh Viswanathan
  • Amination process
    Publication number: 20020128490
    Abstract: The present invention provides methodology for carbon-nitrogen bond formation via vinyl or aryl amination. In the process of the invention, an sp2 hybridized radical is reacted with an azomethine moiety to form pyrrolidine and indole compounds. The methodology provides a facile process for the synthesis of compounds having the pyrrolidine or indole subunit and is especially advantageous for compounds having acid or base labile functional groups andor is comprised of chiral centers susceptible to acidbase epimerization.
    Type: Application
    Filed: March 7, 2001
    Publication date: September 12, 2002
    Inventors: Jeffrey N. Johnston, Rajesh Viswanathan