Patents by Inventor Jeffrey N. Weiser

Jeffrey N. Weiser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays for detecting pathogenic respiratory bacteria
    Patent number: 8906630
    Abstract: The present invention encompasses methods, assays and kits for the detection of pathogenic bacteria in a patient and for the differential diagnosis of pulmonary diseases associated with pathogenic bacteria from pulmonary diseases not associated with pathogenic bacteria.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: December 9, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jeffrey N. Weiser, Jane M. Gould
  • Modulating production of pneumococcal capsular polysaccharide
    Patent number: 6642017
    Abstract: The invention relates to methods of modulating capsular polysaccharide production in pneumococci such as Streptococcus pneumoniae. The invention further relates to methods of alleviating pneumococcal infections in animals, and to methods of identifying both agents capable of modulating pneumococcal capsular polysaccharide biosynthesis and agents useful for alleviating pneumococcal infections in animals.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: November 4, 2003
    Assignee: The Children's Hospital of Philadelphia
    Inventor: Jeffrey N. Weiser
  • Modulating production of pneumococcal capsular polysaccharide
    Publication number: 20030021811
    Abstract: The invention relates to methods of modulating capsular polysaccharide production in pneumococci such as Streptococcus pneumoniae. The invention further relates to methods of alleviating pneumococcal infections in animals, and to methods of identifying both agents capable of modulating pneumococcal capsular polysaccharide biosynthesis and agents useful for alleviating pneumococcal infections in animals.
    Type: Application
    Filed: January 30, 2002
    Publication date: January 30, 2003
    Inventor: Jeffrey N. Weiser
  • Compositions and methods for treatment of streptococcus pneumoniae infection
    Patent number: 5976542
    Abstract: The invention relates to an isolated nucleic acid encoding Streptococcus pneumoniae IgA protease and an isolated polypeptide comprising Streptococcus pneumoniae IgA protease and methods of use thereof.
    Type: Grant
    Filed: January 29, 1997
    Date of Patent: November 2, 1999
    Assignee: New England Medical Center
    Inventors: Jeffrey N. Weiser, Andrew G. Plaut, Joanne V. Gilbert-Rothstein
  • Compositions and methods for treatment of infection caused by Haemophilus influenzae and Streptococcus pneumoniae
    Patent number: 5871951
    Abstract: The invention relates to a method of identifying a compound capable of disrupting the addition of choline onto a bacterial cell surface component comprising incubating a sample of bacteria in a solution containing choline in the presence or absence of a test compound, and assessing the effect of the test compound on the addition of choline onto the bacterial cell surface component, wherein a lower level of choline on the cell surface component in the presence of the test compound, compared with the level of choline on the cell surface component in the absence of the test compound, is an indication that the test compound inhibits the addition of choline onto the cell surface component.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: February 16, 1999
    Assignee: The Children's Hospital of Philadelphia
    Inventor: Jeffrey N. Weiser
  • Opacity associated proteins, DNA encoding the same, and methods of use thereof
    Patent number: 5756105
    Abstract: Opacity associated proteins and DNA encoding the same are provided by the present invention. Opacity associated proteins are membrane proteins of H. influenzae which are useful as immunogens in vaccines against infection by H. influenzae. Recombinant cells transformed with DNA encoding opacity associated proteins and vectors encoding the same are also provided and are useful in and for the preparation of vaccines against H. influenzae infection. Antibodies against opacity associated proteins are also described. Methods of detecting H. influenzae in a sample and methods of immunizing mammals against H. influenzae are also provided.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: May 26, 1998
    Assignee: Children's Hospital of Philadelphia
    Inventor: Jeffrey N. Weiser