Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system use Spodoptera frugiperda insect cells (such as Sf9 or Sf21) as viral production cells (VPCs).

Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant adeno-associated virus (rAAV) particles. The production process and system use Baculoviral Expression Vectors (BEVs) and/or Baculoviral Infected Insect Cells (BIICs) in the production of AAV particles (e.g., rAAVs) which allow for the controlled expression of AAV structural (e.g., capsid) proteins, such as VP1, VP2, and VPS and the controlled expression of AAV nonstructural (e.g., replication) proteins, such as Rep78 and Rep52.

Abstract: A method of improving at least one of quality and yield of a physical process comprises: obtaining values, from respective performances of the physical process, for a plurality of variables associated with the physical process; determining at least one Gaussian mixture model (GMM) representing the values for the variables for the performances of the physical process; based at least in part on the at least one GMM, computing at least one anomaly score for at least one of the variables for at least one of the performances of the physical process; based on the at least one anomaly score, identifying the at least one of the performances of the physical process as an outlier; and, based at least in part on the outlier identification, modifying the at least one of the variables for one or more subsequent performances of the physical process.

Abstract: An embodiment includes extracting, by a scheduler, function-tag data associated with a function identified by a deployment request. The embodiment also includes selecting, by the scheduler, a computing device within a server cluster to host the function based at least in part on a comparison of the function-tag data and host-tag data associated with the computing device. The embodiment also includes issuing, by the scheduler, an instruction to the computing device, wherein the issuing of the instruction causes an allocation of resources for hosting execution of the function.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: A method of implementing administrative services for a compensation platform is disclosed. One or more interactive compensation representation views are generated based on an evaluation of mapping rules against a flexible ontology and current data state, the flexible ontology comprising customizable compensation components, relationships, and properties. One or more compensation representation views are dynamically updated in real-time in response to changes in compensation data, user context, or access permissions without requiring manual regeneration of the one or more compensation representations. The one or more interactive compensation representation views include a user interface element displayed in response to a user selection of compensation data, wherein the user interface element provides direct access to compensation information relevant to the selected compensation data without requiring a change to another screen or another user context.

Abstract: A method of generating customizable goal representation is disclosed. A request from a user to view a goal representation is received. A flexible goal ontology is accessed that comprises one or more goal entities, one or more goal relationships between the goal entities, or one or more goal properties, the one or more goal properties including one or more metadata attributes relating to the one or more goal entities. A set of mapping rules is obtained that defines mappings between one or more goals. The set of mapping rules is evaluated to assemble a customized goal representation tailored to the user. The customized goal representation is updated based on a revaluation of the mapping rules affected by changes to the one or more goal entities, the one or more goal relationships, or the one or more properties.

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

Abstract: A handle of an endoscope may comprise a body portion that defines a first chamber having a first feature configured to support at least a first component of a steering assembly, and a second chamber having a second feature configured to support at least one fluidic component or electronic component.

Abstract: Certain aspects relate to percutaneous sheaths for medical procedures as well as to related systems and methods. For example, a system for performing a percutaneous assisted medical procedure can include a percutaneous sheath. The percutaneous sheath can include a first conduit for providing aspiration into the kidney and a second conduit for passing a catheter into the kidney. The system can also include an aspiration catheter configured to be inserted into the kidney through the second conduit of the percutaneous sheath. A fluidics system can include an irrigation source comprising a pump and an aspiration source comprising a vacuum. The irrigation source can be connected to a fluid inlet of the percutaneous sheath that is connected to the first conduit. The aspiration source can be connected to the aspiration catheter.

Abstract: A clasp assembly includes a pair of identical half sections configured to be coupled to one another. Each half section comprises one or more deformable features that are designed to deform during closure to create an interlocking engagement between each half section.

Abstract: A flywheel energy storage system comprises a rotor having a rotational axis about which the rotor spins in operation and comprising a ferrous material and a housing enclosing the rotor and having an interior subject to a vacuum. The system further comprises a vacuum pump configured to provide the vacuum of the interior of the housing, an electromagnet configured to apply a magnetic field and lift the rotor vertically along the rotational axis of the rotor, and at least one bearing provided between the rotor and the housing, and a controller in operative communication with the electromagnet and the vacuum pump. The rotor applies a force against the at least one bearing.

Abstract: A clasp assembly includes a pair of identical half sections configured to be coupled to one another. Each half section comprises one or more deformable features that are designed to deform during closure to create an interlocking engagement between each half section.

Abstract: A monitoring system having a heads-up display may include a receiver, a transmitter, and a monitor device. The monitoring system may be designed to display video information in a peripheral field and may be designed to display real-time information while minimizing latency. The monitoring system may provide for the monitoring or recording of patient vital information by a healthcare professional performing medical tasks.

Abstract: A monitoring system having a heads-up display may include a receiver, a transmitter, and a monitor device. The monitoring system may be designed to display video information in a peripheral field and may be designed to display real-time information while minimizing latency. The monitoring system may provide for the monitoring or recording of patient vital information by a healthcare professional performing medical tasks.

Abstract: A flywheel energy storage system comprises a rotor having a rotational axis about which the rotor spins in operation and comprising a ferrous material and a housing enclosing the rotor and having an interior subject to a vacuum. The system further comprises a vacuum pump configured to provide the vacuum of the interior of the housing, an electromagnet configured to apply a magnetic field and lift the rotor vertically along the rotational axis of the rotor, and at least one bearing provided between the rotor and the housing, and a controller in operative communication with the electromagnet and the vacuum pump. The rotor applies a force against the at least one bearing.

Abstract: A L0 cache is provided that includes a plurality of memory cells, full swing signal bit lines coupled to the plurality of memory cells to output full swing data signals, small signal global bit lines coupled to the full swing signal bit lines to provide small signal data signals, and an alignment device to align signals on the small signal global bit lines.