Patents by Inventor Jeffrey North

Jeffrey North has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical probes to identify anti-mycobacterial MmpL3 inhibitors
    Patent number: 11608328
    Abstract: The present application provides detectable compounds useful for identifying compounds that bind (e.g., inhibit) MmpL3. Methods of identifying compounds that bind and/or inhibit MmpL3 are also provided.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: March 21, 2023
    Assignees: Creighton University, Colorado State University Research Foundation
    Inventors: E. Jeffrey North, Amitkumar Navinchandra Pandya, Mary C. Jackson, Wei Li, Mercedes Gonzalez-Juarrero
  • Chemical Probes to Identify Anti-Mycobacterial MmpL3 Inhibitors
    Publication number: 20200331897
    Abstract: The present application provides detectable compounds useful for identifying compounds that bind (e.g., inhibit) MmpL3. Methods of identifying compounds that bind and/or inhibit MmpL3 are also provided.
    Type: Application
    Filed: February 21, 2020
    Publication date: October 22, 2020
    Applicants: Creighton University, Colorado State University Research Foundation
    Inventors: Jeffrey North, Amitkumar Navinchandra Pandya, Mary Jackson, Wei Li, Mercedes Gonzalez-Juarrero
  • Indole-based therapeutics
    Patent number: 10383848
    Abstract: Provided herein are indole-2-carboxamide compounds useful for the treatment of non-tuberculosis bacterial infections. Exemplary compounds provided herein are useful for the treatment of non-tuberculosis mycobacterial infections. Methods for preparing the indole-2-carboxamide compounds are also provided.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: August 20, 2019
    Assignees: Creighton University, Colorado State University Research Foundation
    Inventors: Jeffrey North, Mary C. Jackson
  • INDOLE-BASED THERAPEUTICS
    Publication number: 20180036283
    Abstract: Provided herein are indole-2-carboxamide compounds useful for the treatment of non-tuberculosis bacterial infections. Exemplary compounds provided herein are useful for the treatment of non-tuberculosis mycobacterial infections. Methods for preparing the indole-2-carboxamide compounds are also provided.
    Type: Application
    Filed: August 4, 2017
    Publication date: February 8, 2018
    Inventors: Jeffrey North, Mary C. Jackson
  • Diverse lead compound autotaxin inhibitors
    Patent number: 8343934
    Abstract: Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include naphthalenesulfones, phenylsulfones, and certain peptides with unnatural amino acids and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: January 1, 2013
    Assignee: University of Memphis
    Inventors: Abby Louise Parrill-Baker, Daniel Lee Baker, Elton Jeffrey North
  • Novel Diverse Lead Compound Autotaxin Inhibitors
    Publication number: 20110160148
    Abstract: Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include naphthalenesulfones, phenylsulfones, and certain peptides with unnatural amino acids and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.
    Type: Application
    Filed: June 30, 2010
    Publication date: June 30, 2011
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Abby Louise Parrill-Baker, Daniel Lee Baker, Elton Jeffrey North