Patents by Inventor Jeffrey O. Hollinger
Jeffrey O. Hollinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190350843Abstract: The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.Type: ApplicationFiled: March 22, 2019Publication date: November 21, 2019Inventors: Charles E. Hart, Jeffrey O. Hollinger, Samuel E. Lynch
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Patent number: 10258566Abstract: The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.Type: GrantFiled: June 18, 2010Date of Patent: April 16, 2019Assignee: BIOMIMETIC THERAPEUTICS, LLCInventors: Charles E. Hart, Jeffrey O. Hollinger, Samuel E. Lynch
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Publication number: 20150093821Abstract: A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at least one reactive group —X which is a hydroxyl group (—OH) or an amine group (—NH2). The polyurethane composition is biodegradable within a living organism to biocompatible degradation products including the bioactive agent. Preferably, the released bioactive agent affects at least one of biological activity or chemical activity in the host organism. A biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is preferably derived from a diurea diol or a diester diol and is preferably biodegradable into biomolecule degradation products or into biomolecule degradation products and a biocompatible diol. Another biodegradable polyurethane composition includes hard segments and soft segments.Type: ApplicationFiled: October 10, 2014Publication date: April 2, 2015Inventors: Eric J. Beckman, Jeffrey O. Hollinger, Bruce A. Doll, Scott A. Guelcher, Jianying Zhang
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Publication number: 20130011441Abstract: The present invention relates to nanostructured bioconjugates and nano-structured network hydrogels used to deliver nucleic acids to targeted biological locations. The present invention further relates to methods of treating clinical conditions using the nanostructured bioconjugates and nano-structured network hydrogels.Type: ApplicationFiled: January 6, 2012Publication date: January 10, 2013Applicant: Carnegie Mellon UniversityInventors: Jeffrey O. Hollinger, Krzysztof Matyjaszewski, Abiraman Srinivasan
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Patent number: 8318820Abstract: A method of synthesizing of a biocompatible and biodegradable polyurethane foam includes the steps of: mixing at least one biocompatible polyol, water, at least one stabilizer, and at least one cell opener, to form a resin mix; contacting the resin mix with at least one polyisocyanate to form a reactive liquid mixture; and reacting the reactive liquid mixture form a polyurethane foam. The polyurethane foam is preferably biodegradable within a living organism to biocompatible degradation products. At least one biologically active molecule having at least one active hydrogen can be added to form the resin mix.Type: GrantFiled: November 5, 2005Date of Patent: November 27, 2012Assignee: Carnegie Mellon UniversityInventors: Scott A. Guelcher, Vishal Patel, Jeffrey O. Hollinger, Jonathan Didier
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Publication number: 20110117018Abstract: The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.Type: ApplicationFiled: June 18, 2010Publication date: May 19, 2011Applicant: BioMimetic Therapeutics, Inc.Inventors: Charles E. HART, Jeffrey O. HOLLINGER, Samuel E. LYNCH
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Patent number: 7799754Abstract: The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.Type: GrantFiled: February 9, 2007Date of Patent: September 21, 2010Assignee: Biomimetic Therapeutics, Inc.Inventors: Charles E. Hart, Jeffrey O. Hollinger, Samuel E. Lynch
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Publication number: 20100151025Abstract: The present invention provides compositions and methods useful for treating, preventing or slowing the progression of ONJ and ORNJ. The invention provides for the use of PDGF in a pharmaceutically acceptable buffer in the preparation of a medicament useful for treating, preventing or slowing the progression of ONJ and ORNJ. The invention provides for the use of PDGF in a pharmaceutically acceptable buffer wherein the PDGF is disposed in a biocompatible matrix in the preparation of a medicament useful for treating, preventing or slowing the progression of ONJ and ORNJ. In one embodiment, a method for treating, preventing or slowing the progression of ONJ or ORNJ comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix and applying the composition to a desired site in the jaw.Type: ApplicationFiled: February 20, 2008Publication date: June 17, 2010Applicant: BIOMIMETIC THERAPEUTICS, INC.Inventors: Samuel E. Lynch, Jeffrey O. Hollinger, Leslie A. Wisner-Lynch
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Publication number: 20090221784Abstract: A method for preparing biodegradable polyurethanes includes contacting a flowable quasi-pre-polymer including free aliphatic polyisocyanate compounds with a polyester polyol hardener having a functionality of at least two to form a reactive liquid mixture. The quasi-prepolymer can, for example, be formed by contacting a polyisocyanate component comprising at least one aliphatic polyisocyanate compound with a polyol component comprising at least one polyol compound to form an adduct of the polyisocyanate component and the polyol component wherein a sufficient excess of the polyisocyanate component is used to form the quasi-prepolymer.Type: ApplicationFiled: April 24, 2006Publication date: September 3, 2009Inventors: Scott A. Guelcher, Jonathan E. Didier, Jeffrey O. Hollinger
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Patent number: 7208179Abstract: This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one oligonucleotide. The composition may be further supplemented with, for example, one or more analgesics, antimicrobial compositions, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.Type: GrantFiled: June 7, 1995Date of Patent: April 24, 2007Assignee: The American National Red CrossInventors: William N. Drohan, Martin James MacPhee, Jeffrey O. Hollinger
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Publication number: 20030235564Abstract: A pharmaceutical composition comprising in combination the Runx2 protein, a polynucleotide encoding the Runx2 protein, or a cell that has been transformed with a polynucleotide encoding Runx2 protein, in a pharmaceutically acceptable carrier, the carrier comprising a bio-compatible, biodegradable polymeric matrix. Another aspect of the present invention includes a device comprising the above-described pharmaceutical composition in combination with a sterile and substantially antigen-free, pre-shaped allograft or xenograft bone implant. Also contemplated herein is a method for repairing a bone defect comprising administering to a mammalian patient at the site in need of treatment a pharmaceutical composition, comprising in combination the Runx2 protein, a polynucleotide encoding the Runx2 protein, or a cell that has been transformed with a polynucleotide encoding Runx2 protein, in a pharmaceutically acceptable carrier wherein the carrier is a bio-compatible, biodegradable polymeric matrix.Type: ApplicationFiled: May 13, 2003Publication date: December 25, 2003Inventors: Bruce Doll, Huihua Fu, Jeffrey O. Hollinger, Charles Sfeir
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Publication number: 20030219466Abstract: Provided is a method for production of nanocrystalline hydroxyapatite particles, and nanocrystalline hydroxyapatite particles produced according to the method. The nanocrystalline hydroxyapatite particles exhibit substantially superior cell transformation abilities as compared to known and commercially-available calcium phosphate kits. The nanocrystalline hydroxyapatite particles also find use in tissue engineering applications, for example bone and tooth engineering and repair applications.Type: ApplicationFiled: March 19, 2003Publication date: November 27, 2003Inventors: Prashant N. Kumta, Charles S. Sfeir, Jeffrey O. Hollinger, Daiwon Choi, Lee Weiss, Phil Campbell
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Patent number: 5011495Abstract: Although many materials have been used for osseous wound repair, no agent rrently available provides the surgeon with a predictable level of bone regeneration. Because they do not elicit elicit immunologic responses, and because of the disadvantages of obtaining donor bone, ceramic compositions such as phosphate-bonded alumina and similar ceramics have been investigated as possible bone substitutes capable of promoting bone growth. Since ceramic tricalcium phosphate is biodegradable it has been the subject of considerable research. Despite the research effort, the use of tricalcium phosphate ceramic materials in the regeneration of bone is still subject to improvement. A distinctive form of ceramic beta tricalcium phosphate, modified to augment bone regeneration is provided herein. It is readily implantable in a bone cavity to promote formation throughout the cavity of new bone to replace that lost through trauma, disease, respective surgery, and birth defects.Type: GrantFiled: February 16, 1990Date of Patent: April 30, 1991Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Jeffrey O. Hollinger
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Patent number: 4717115Abstract: The invention is directed to an adjustable mold for use in fabricating bigradable polymeric bone replacements or implants. The invention consists of a box-like structure with two movable plates therein which can be locked into place permitting different size replacements to be fabricated. The interior walls are panels consisting of polytetrafluoroethylene which permit easy removal of a cured bone replacement. The construction and locking means for the movable plates permit the invention to withstand the pressures developed in replacement fabrication as well as to withstand the most commonly used types of sterilization procedures.Type: GrantFiled: October 14, 1986Date of Patent: January 5, 1988Assignee: The United States of America as represented by the Secretary of the ArmyInventors: John P. Schmitz, Jeffrey O. Hollinger
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Patent number: 4578384Abstract: A novel material consisting of a combination of a proteolipid and biodegradable, biocompatible copolymer has been developed for improving and accelerating the healing of osseous tissue. The proteolipid was prepared by combining muco-peptide-N-acetyl-muramoylhydrolase with phosphatidyl inositol, 4,5-diphosphate and the copolymer consists essentially of a 50:50 poly(L)(-)lactide co-glycolide.Type: GrantFiled: February 15, 1984Date of Patent: March 25, 1986Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Jeffrey O. Hollinger
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Patent number: RE39321Abstract: This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, antiinflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and/or using the unsupplemented or supplemented fibrin sealant dressing.Type: GrantFiled: June 20, 2003Date of Patent: October 3, 2006Assignee: The American National Red CrossInventors: Martin J. MacPhee, William N. Drohan, Gene Liau, Hernan Nunez, Wilson H. Burgess, Jeffrey O. Hollinger, Thomas Maciag
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Patent number: H571Abstract: The invention is directed to a simple attachment for a surgical bone cutt or osteotomy saw. The invention, consisting of a calibrated T-bar, saw blade holder assemblies, and cooling assemblies, permits two standard surgical saw blades to be attached in parallel to a nitrogen powered surgical reciprocating saw. Thus, a surgeon can make measured, parallel bone cuts in a single motion. The cooling assemblies, pivotally attached to the blade holder assemblies, permit water to be directed down and into the surgical site during the entire cutting operation thereby eliminating bone necrosis and reducing the risk of post-surgical bone morbidity.Type: GrantFiled: February 20, 1986Date of Patent: February 7, 1989Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Jeffrey O. Hollinger, John P. Schmitz, Eric S. Koppelman