Abstract: There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and/or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

Abstract: A method and apparatus for delivery of cell therapies, introduced via percutaneous access to the circulation, and delivered to the site of vascular injury or intervention.

Abstract: A system for heating a selected section of a conductive ribbon comprises a non-conductive base and conducting pads. Further, the system comprises a variable voltage power supply electrically coupled to the conducting pads and a sensor. A processor is programmed to enable the variable power supply to produce a voltage signal across the conducting pads to cause the selected section, which includes a biological sample and is clamped to the non-conductive base via the conducting pads, to heat up. The processor receives, from the sensor, an electrical measurement. A correction for the voltage signal is computed based on the measurement to achieve a desired temperature, wherein the desired temperature is for processing the biological sample and the correction accounts for a variance in the selected section. The applied voltage signal is adjusted based upon the correction to regulate the selected section of at the desired temperature for a time.

Abstract: There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and/or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

Abstract: There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and/or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

Abstract: A system for heating a selected section of a conductive ribbon comprises a non-conductive base and conducting pads. Further, the system comprises a variable voltage power supply electrically coupled to the conducting pads and a sensor. A processor is programmed to enable the variable power supply to produce a voltage signal across the conducting pads to cause the selected section, which includes a biological sample and is clamped to the non-conductive base via the conducting pads, to heat up. The processor receives, from the sensor, an electrical measurement. A correction for the voltage signal is computed based on the measurement to achieve a desired temperature, wherein the desired temperature is for processing the biological sample and the correction accounts for a variance in the selected section. The applied voltage signal is adjusted based upon the correction to regulate the selected section of at the desired temperature for a time.

Abstract: Systems and methods of heating a conductive ribbon for sample collection and/or sample processing comprises coupling conducting pads to the conductive ribbon, applying a signal across the conducting pads to cause the conductive ribbon to heat up, taking a measurement of at least one electrical property associated with the conductive ribbon in response to the applied signal, computing a correction for the applied signal to achieve a desired temperature suitable for fixing a sample to the heated conductive ribbon, and adjusting the applied signal to regulate the heat of the conductive ribbon to the desired temperature for a predetermined time.

Abstract: A device comprises a reactive semiconductor bridge including a conductive metal, a reactive material, and an overcoat. When a high current passes through the reactive semiconductor bridge, the conductive metal vaporizes into a high temperature plasma. The reactive material is coupled to the conductive metal such that the conductive metal experiences an exothermic reaction to the plasma. When the conductive metal turns to plasma, the overcoat material absorbs at least a part of the exothermic reaction of the reactive material and breaks into a plurality of particles that are propelled away from the bridge. A gap is disposed between the overcoat and a membrane, and an explosive material couples to the membrane. The plurality of particles crosses the gap and penetrates the membrane to ignite the explosive material in response to being propelled away from the bridge.

Abstract: An exploding foil initiator system comprises a substrate having a first side and a second side, an exploding foil initiator and surface mount pads. The exploding foil initiator is formed on the first side of the substrate and comprises a first contact, a second contact and a channel that electrically connects the first contact and the second contact. A first surface mount pad is formed on the second side of the substrate. As second surface mount pad is also formed on the second side of the substrate. A first via extends through the substrate to electrically connect the first contact with the first surface mount pad. Analogously, a second via extends through the substrate to electrically connect the second contact to the second surface mount pad.

Abstract: A device comprises a reactive semiconductor bridge including a conductive metal, a reactive material, and an overcoat. When a high current passes through the reactive semiconductor bridge, the conductive metal vaporizes into a high temperature plasma. The reactive material is coupled to the conductive metal such that the conductive metal experiences an exothermic reaction to the plasma. When the conductive metal turns to plasma, the overcoat material absorbs at least a part of the exothermic reaction of the reactive material and breaks into a plurality of particles that are propelled away from the bridge. A gap is disposed between the overcoat and a membrane, and an explosive material couples to the membrane. The plurality of particles crosses the gap and penetrates the membrane to ignite the explosive material in response to being propelled away from the bridge.

Abstract: There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and/or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

Abstract: There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and/or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

Abstract: An exploding foil initiator system comprises a substrate having a first side and a second side, an exploding foil initiator and surface mount pads. The exploding foil initiator is formed on the first side of the substrate and comprises a first contact, a second contact and a channel that electrically connects the first contact and the second contact. A first surface mount pad is formed on the second side of the substrate. As second surface mount pad is also formed on the second side of the substrate. A first via extends through the substrate to electrically connect the first contact with the first surface mount pad. Analogously, a second via extends through the substrate to electrically connect the second contact to the second surface mount pad.

Abstract: A fluorescence-cued Raman identification system comprises a collection subsystem to collect samples, a reagent treatment subsystem to treat collected samples and a fluorescence imaging subsystem that automatically takes at least one image of the collected sample. The subsystems further include a Raman spectroscopy subsystem that measures the spectrum of viable organisms located from at least one collected image, a visible imaging microscope subsystem that provides a visual image of the particle analyzed by the Raman spectroscopy subsystem and a processor configured to perform image processing to locate viable organisms within the sample, which are targeted by the Raman spectroscopy subsystem. The processor further analyzes the spectrum recorded by the Raman spectroscopy subsystem to make a preliminary identification of the targeted organisms, which can be verified by an operator using the visible imaging microscope subsystem.

Abstract: A fluorescence-cued Raman identification system comprises a collection subsystem to collect samples, a reagent treatment subsystem to treat collected samples and a fluorescence imaging subsystem that automatically takes at least one image of the collected sample. The subsystems further include a Raman spectroscopy subsystem that measures the spectrum of viable organisms located from at least one collected image, a visible imaging microscope subsystem that provides a visual image of the particle analyzed by the Raman spectroscopy subsystem and a processor configured to perform image processing to locate viable organisms within the sample, which are targeted by the Raman spectroscopy subsystem. The processor further analyzes the spectrum recorded by the Raman spectroscopy subsystem to make a preliminary identification of the targeted organisms, which can be verified by an operator using the visible imaging microscope subsystem.

Abstract: A biological and chemical detection system is provided that detects and identifies biological and/or chemical particulates of interest. The biological and chemical detection system comprises a collector, a first optical device, a second optical device and a processor. The collector is configured to deposit particulates drawn from a fluid stream onto a sample substrate to define a sample area. The first optical device derives first data relative to at least a portion of the sample area, which is analyzed to determine at least one field of view and/or specific target location. The second optical device then interrogates the sample area at each determined target location, e.g., using Raman spectroscopy, to produce interrogation data.

Abstract: There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and/or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. The deflector shaft could have a first portion and a second portion, the second portion being more flexible than the first portion. The deflector frame can include one, two, or more movable structures, such as hinges. Also disclosed are methods for insertion and removal of the deflector.

Abstract: A biological and chemical detection system is provided that detects and identifies biological and/or chemical particulates of interest. The biological and chemical detection system comprises a collector, a first optical device, a second optical device and a processor. The collector is configured to deposit particulates drawn from a fluid stream onto a sample substrate to define a sample area. The first optical device derives first data relative to at least a portion of the sample area, which is analyzed to determine at least one field of view and/or specific target location. The second optical device then interrogates the sample area at each determined target location, e.g., using Raman spectroscopy, to produce interrogation data.

Abstract: There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and/or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.