Abstract: The instant invention provides methods and compositions for the treatment of infection or infectious colonization of the eyelid and/or ocular surface for the treatment and prevention of ocular disorders and eyelid disorders.

Abstract: The present invention is directed to anti-microbial cleanser compositions comprising linalool, hinokitiol and dipropylene glycol. The present invention further provides methods for using these compositions to maintain eyelid hygiene, to treat an ocular disorder or to clean a skin surface. The cleanser compositions of the present invention can be in the form of a foam, gel or liquid.

Abstract: The instant invention provides methods and compositions for the treatment of infection or infectious colonization of the eyelid and/or ocular surface for the treatment and prevention of ocular disorders and eyelid disorders.

Abstract: A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine concentrations of solutes such as salt and antigenic analytes in the tear sample.

Abstract: The present invention is directed to anti-microbial cleanser compositions comprising linalool, hinokitiol and dipropylene glycol. The present invention further provides methods for using these compositions to maintain eyelid hygiene, to treat an ocular disorder or to clean a skin surface. The cleanser compositions of the present invention can be in the form of a foam, gel or liquid.

Abstract: The present invention provides stable aqueous doxycycline aqueous solutions suitable for pharmaceutical, especially ophthalmic, use. The doxycycline aqueous solutions have a pH ranging from 4.5-8, and contain an antioxidant and a stabilizer such as caffeine, creatine or mixtures thereof. The solutions have improved lifetimes and can be used topically.

Abstract: Nutritional supplements for eye health comprising: an anti-oxidant component; an anti-inflammatory component; and an anti-angiogenic component. The supplements inhibit development and progression of a range of retinal diseases and degenerations, particularly AMD and diabetic eye disease, diabetic retinopathy and diabetic macular edema. The supplements include tocotrienol and green tea extract.

Abstract: The instant invention provides methods and compositions for the treatment of infection or infectious colonization of the eyelid and/or ocular surface for the treatment and prevention of ocular disorders and eyelid disorders.

Abstract: Nutritional supplements for eye health comprising: an anti-oxidant component; an anti-inflammatory component; and an anti-angiogenic component. The supplements inhibit development and progression of a range of retinal diseases and degenerations, particularly AMD and diabetic eye disease, diabetic retinopathy and diabetic macular edema. The supplements include tocotrienol and green tea extract.

Abstract: A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine concentrations of solutes such as salt and antigenic analytes in the tear sample.

Abstract: The instant invention provides preparations comprising an oxidizing antimicrobial agent such as chlorine dioxide and a heterocyclic compound that improves the antibacterial effect of the oxidizing antimicrobial agent preparation. The invention has particular use as an eye care preparation such as an eye drop. The invention further provides methods for reducing bacterial colonization and treating infection.

Abstract: Nutritional supplements for treating dry eye, meibomian gland inflammation, meibomian gland dysfunction or xerostomia comprising flaxseed oil, or a GLA-rich oil, combined with a n-3 rich oil, such as fish oil which is rich in eicosapentaenoic acid (EPA) and docosahexaeonic acid (DHA), are disclosed. Methods of treating dry eye, meibomian gland inflammation, meibomian gland dysfunction or dry mouth by administering the supplements are also described.

Abstract: Ophthalmic compositions and methods of using the same to simultaneously treat eye surface inflammation and dry eye are disclosed. The ophthalmic preparation contains a tetracycline compound in aqueous solution. The preparation preferably further includes a balance of electrolytes sufficient to maintain or restore essentially normal levels of conjunctival mucus-containing goblet cells and corneal glycogen. These electrolytes can include potassium, chloride, bicarbonate, sodium, calcium, magnesium and phosphate.

Abstract: A method and preparation for the stimulation of tear secretion. The method involves topically applying a phosphodiesterase inhibitor and/or cyclic nucleotide analogue to the ocular surface. Inhibition of phosphodiesterase and cyclic nucleotide analogues increase cyclic nucleotide levels in lacrimal gland tissue, thereby stimulating tear secretion. The preparation contains a phosphodiesterase inhibitor or a cyclic nucleotide analogue and a vehicle for the phosphodiesterase inhibitor or cyclic nucleotide analogue, and may contain an ophthalmic preservative.

Abstract: A multidose liquid dispenser for maintaining the sterility of solutions without a preservative has been developed. The dispenser includes a filter assembly having a hydrophobic filter and a hydrophilic filter in tandem with the hydrophobic filter located near the dispensing tip. The use of the hydrophobic exterior filter and the hydrophilic interior filter permits excellent liquid flow while precluding the growth of bacteria on the filter. The inability of the bacteria to attach to the exterior hydrophobic filter prevents clogging of the pores.

Abstract: An ophthalmic preparation and a method for preparing the ophthalmic preparation is described. The ophthalmic preparation has an enhanced ability to permit essentially normal maintenance of ocular surface mucus-containing goblet cells while present in the eye.

Abstract: A method and preparation for the stimulation of tear secretion. The method involves topically applying to the ocular surface melanocyte stimulating hormones, and their active precursors, derivatives, and fragments which activate melanotropin receptors of lacrimal gland tissue. The preparation contains a melanocyte stimulating hormone, and a vehicle for a melanocyte stimulating hormone and may also contain an ophthalmic preservative.

Abstract: An ophthalmic preparation and a method for preparing the ophthalmic preparation is described. The ophthalmic preparation has an enhanced ability to permit essentially normal maintenance of ocular surface mucus-containing goblet cells while present in the eye.

Abstract: A method and preparation for the stimulation of tear secretion. The method involves topically applying a phosphodiesterase inhibitor and/or cyclic nucleotide analogue to the ocular surface. Inhibition of phosphodiesterase and cyclic nucleotide analogues increase cyclic nucleotide levels in lacrimal gland tissue, thereby stimulting tear secretion. The preparation contains a phosphodiesterase inhibitor or a cyclic nucleotide analogue and a vehicle for the phosphodiesterase inhibitor or cyclic nucleotide analogue, and may contain an ophthalmic preservative.