Abstract: An apparatus includes a body, a shaft, a stapling head assembly, and an anvil. The body includes a motor, a first user input feature, and a second user input feature. The first user input feature is operable to activate the motor. The shaft extends distally from the body. The stapling head assembly is positioned at a distal end of the shaft. The stapling head assembly includes an anvil coupling feature, at least one annular array of staples, and a staple driver. The second user input feature is operable to drive the anvil coupling feature longitudinally. The staple driver is operable to drive the at least one annular array of staples. The motor is operable to drive the staple driver. The anvil is configured to couple with the anvil coupling feature. The anvil is further configured to deform the staples driven by the staple driver.

Abstract: Embodiments described herein generally relate to a customizable management system for various unique packaging production architectures. The customizable management system can be configurable to universally integrate with various systems within a variety of unique packaging production architectures. For example, the customizable management system can comprise one or more importer modules that receive package creation requests and translate the requests into a second format that is readable by one or more staging and selection modules. The system may also comprise staging and selection modules that are configured to identify within each translated packaging creation order one or more final packaging parameters and identify a workgroup that is capable of meeting the one or more final packaging parameters. The system may also comprise one or more machine group modules in communication with one or more packaging stations.

Abstract: The present invention relates to novel pharmaceutical composition comprising meloxicam for the treatment of acute pain, wherein the composition comprises at least a hydrophilic polymer and one or more alkalizing agents or combinations thereof.

Abstract: A process system and method for the making of articles, using an omnidirectional magnetic movement system with a transport surface and fabrication modules having a formation surface that can be transported omnidirectionally over the transport surface under the control of a movement controller. An article forming system provides process unit operations for forming articles onto the formation surface as the fabrication modules are moved asynchronously between a plurality of processing positions on the transport surface, and features a depositing device for placing a construction material onto the formation surface and one or more processing devices to form the construction material into the article.

Abstract: Oral solid pharmaceutical compositions containing meloxicam co-crystals described herein allow for the use of meloxicam for the treatment of acute pain. In particular, the improved dissolution and bioavailability of the meloxicam co-crystal compositions provide more rapid uptake of meloxicam in vivo as evidenced by increase blood plasma concentrations in a decreased amount of time following administration. A correlation between improved plasma concentrations and in vivo analgesic action are provided for the first time.

Abstract: The solubility and bioavailability properties of meloxicam can be improved by preparing compositions of meloxicam co-crystals and reducing the particle size of (e.g., “nanosizing”) co-crystals. Such compositions with improved dissolution pharmacokinetic properties can be prepared by granulation and blending the co-crystals with extragranular excipients to provide oral solid dosage forms. As a result of the improved properties of the meloxicam oral dosage forms, the compositions may be useful for the treatment of pain, including acute pain.

Abstract: A tire comprising a plurality of tread blocks. At least one tread block includes one or more piers for stiffening the tread blocks while allowing normal lateral (tangential) or circumferential strain for normal braking and motive traction.

Abstract: A quarter panel is configured for use with a vehicle having a forward end, a wheel, and a vertical surface located forward of the wheel. The quarter fender assembly includes a quarter fender in the form of an arcuate panel. The quarter panel is sized and configured to be mounted to the vehicle between the wheel and the vertical surface. The quarter panel assembly further includes a flexible flap mounted to an upper portion of the quarter fender. The flap has an at least partially arcuate forward surface.

Abstract: Drag reducing systems for vehicles are provided. In one aspect, a drag reducing system generally includes an airfoil rotatably couplable to the vehicle and configured to provide a lift force to the vehicle as a result of differential airflow velocity over the upper surface with respect to the lower surface. The drag reducing system may further include a flow alignment vane to rotationally align the airfoil to the direction of airflow. In another aspect, a drag reducing system generally includes an air vane hingedly couplable to a surface of a vehicle and configured to rotate from a first stowed position to a second deployed position. The air vane includes a flared leading portion to provide a force to bias the air vane toward the first position and a flared lateral portion to provide a force to rotate the air vane to the second deployed position.

Abstract: A tire comprising a plurality of tread blocks. At least one tread block includes one or more piers for stiffening the tread blocks while allowing normal lateral (tangential) or circumferential strain for normal braking and motive traction. The piers can extend the entire length dimension of the tread block or portions thereof.

Abstract: Drag reducing systems for vehicles are provided. In one aspect, a drag reducing system generally includes a flow restricting deflector couplable to a mount and positioned upstream in a path of airflow to an object. The flow restricting deflector generally includes a body portion and a plurality of flow choking orifices configured to provide a choked airflow condition. In another aspect, the drag reducing system is configured for positioning adjacent a wheel and tire combination of a vehicle upstream in a path of airflow to the wheel and tire combination. The flow restricting deflector may be coupled to and extending downward from a splash shield adjacent the wheel and tire combination.

Abstract: Systems and methods for inflating a tire to an operating pressure that is above a cold inflation tire pressure are provided. More specifically, the system may include a tire pressure sensor coupled to a vehicle tire, a compressor configured to provide compressed air to the vehicle tire, a valve between the compressor and the vehicle tire; and a controller configured to: access a tire parameter associated with the vehicle tire, receive a tire pressure of the vehicle tire from the tire pressure sensor, and when then tire pressure received from the tire pressure is less than an operating tire pressure that is based on the accessed tire parameter, cause the valve to pass pressurized air from the compressor to the vehicle tire, wherein the operating tire pressure is greater than a cold inflation tire pressure of the vehicle tire.

Abstract: A disclosed lift axle is suitable for a vehicle that has a first wheel for supporting the vehicle on a road surface. The lift axle system includes a lift mechanism that is coupled to the vehicle and is configured to reciprocate an axle between a stowed position and deployed position. The lift axle system further includes a second wheel coupled to the axle. The second wheel engages the road surface when the lift mechanism is in the deployed position, and the second wheel is disengaged from the road surface when the lift mechanism is in the stowed position. The second wheel has a lower rolling resistance than the first wheel.

Abstract: An aerodynamic control system for a ground vehicle comprises a LiDAR module including at least one LiDAR sensor configured to obtain wind data upstream of the ground vehicle; a computing device; an aerodynamic device controller; and an aerodynamic device including a control surface. The computing device is configured to receive the wind data from the LiDAR module and generate output signals based on the wind data. The aerodynamic device controller is configured to receive the output signals from the computing device and generate control signals to control the aerodynamic device to adjust aerodynamic properties of the ground vehicle based at least in part the wind data. Changes to the configuration of the control surface may include increasing or decreasing a deflection angle of the at least one aerodynamic device. The aerodynamic device may include, e.g., a pneumatically actuated aerodynamic device or an electro-mechanically actuated aerodynamic device.

Abstract: A disclosed lift axle is suitable for a vehicle that has a first wheel for supporting the vehicle on a road surface. The lift axle system includes a lift mechanism that is coupled to the vehicle and is configured to reciprocate an axle between a stowed position and deployed position. The lift axle system further includes a second wheel coupled to the axle. The second wheel engages the road surface when the lift mechanism is in the deployed position, and the second wheel is disengaged from the road surface when the lift mechanism is in the stowed position. The second wheel has a lower rolling resistance than the first wheel.

Abstract: A disclosed lift axle is suitable for a vehicle that has a first wheel for supporting the vehicle on a road surface. The lift axle system includes a lift mechanism that is coupled to the vehicle and is configured to reciprocate an axle between a stowed position and deployed position. The lift axle system further includes a second wheel coupled to the axle. The second wheel engages the road surface when the lift mechanism is in the deployed position, and the second wheel is disengaged from the road surface when the lift mechanism is in the stowed position. The second wheel has a lower rolling resistance than the first wheel.