Abstract: The present disclosure relates to methods and compositions of matter to increase the percentage of edited cells in a cell population when employing nucleic-acid guided editing methods, as well as systems and instruments for performing these methods and using these compositions.

Abstract: A nanoparticle includes a copolymer comprising a vinyl-aromatic monomer and a heterocyclic monomer. The copolymer is crosslinked with a multifunctional crosslinking agent polymerizable through an addition reaction. A nanoparticle and elastomer composition is disclosed. Several methods of mixing heterocyclic and non-heterocyclic monomer nanoparticles into an elastomer are also disclosed. These methods include mixing in a multi-elements static mixer and an intermeshing mixer with venting, among others.

Abstract: Embodiments of the present invention include information services, methods and systems to facilitate gathering and management of information by home users and professional users of information gathering, processing, and distribution services, and user interfaces through which users communicate with information services. In one embodiment of the present invention, a central information gathering, processing, and distribution service provides a simple, but robust and highly functional, interface to remote home users and professional users to allow the home users and professional users to continuously receive updated information gleaned from continuous searching of the Internet and other information sources by the information service. The interface allows users to define, refine, and stably store interests that define information searches continuously carried out, on behalf of the user, by the information gathering, processing, and distribution service.

Abstract: Systems and methods for hedging against stock price fluctuations are provided. These systems and methods are preferably directed towards providing executives holding company stock options with opportunities to limit their exposure to fluctuations in the price of stock issued by such companies. This is established through entering into transactions involving stock options with a counterparty.

Abstract: A lock system for casement windows is disclosed which includes a tie bar slidably secured to the flame. The tie bat is secured to a lock handle that is also secured to the flame. The tie bat eliminates the need for rollers riveted to the tie bar by having a first bent section disposed between straight sections and a second bent section disposed between straight sections. All of the straight sections are linearly aligned with one another and at least some of the straight sections of the tie bar are slidably mounted to the flame using conventional guides. The lock system also includes first and second strikers mounted to the sash. The first striker comprising a first ramp that receives a first bent section and the second striker comprising a second ramp that receives a second bent section when the tie bat is slidably moved towards the first and second strikers as the tie bar is moved from an unlocked position to a locked position.

Abstract: The present invention provides an apparatus for resurfacing of an ice surface to provide for dense high quality ice. The apparatus comprises an ice resurfacing machine having a water storage tank connected by delivery pipe to a flood bar assembly to apply water from the water storage to a flood cloth. At least one of the delivery pipe and flood bar assembly are provided with one or more magnets to magnetically treat the water as the water flows through the delivery pipe and the flood bar assembly thereby producing a denser more high quality ice. The present invention also provides for a method of forming an ice surface on a chilled surface, the method comprising passing the water to be applied to the chilled surface through a magnetic field to produce denser, higher quality ice.

Abstract: Systems and methods for hedging against stock price fluctuations are provided. These systems and methods are preferably directed towards providing executives holding company stock options with opportunities to limit their exposure to fluctuations in the price of stock issued by such companies. This is established through entering into transactions involving stock options with a counterparty.