Patents by Inventor Jeffrey Rice

Jeffrey Rice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYPEPTIDE DISPLAY LIBRARIES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20220119802
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Application
    Filed: June 25, 2021
    Publication date: April 21, 2022
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • Polypeptide display libraries and methods of making and using thereof
    Patent number: 11078479
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: August 3, 2021
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • Methods for Enhancing Bacterial Cell Display of Proteins and Peptides
    Publication number: 20210024917
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Application
    Filed: April 8, 2020
    Publication date: January 28, 2021
    Inventors: Patrick Sean Daugherty, Jeffrey Rice
  • POLYPEPTIDE DISPLAY LIBRARIES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20200318099
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Application
    Filed: December 11, 2019
    Publication date: October 8, 2020
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • Methods for enhancing bacterial cell display of proteins and peptides
    Patent number: 10640762
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: May 5, 2020
    Assignee: The Regents of the University of California
    Inventors: Patrick Sean Daugherty, Jeffrey Rice
  • Polypeptide display libraries and methods of making and using thereof
    Patent number: 10544410
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: January 28, 2020
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • POLYPEPTIDE DISPLAY LIBRARIES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20190264194
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Application
    Filed: June 11, 2018
    Publication date: August 29, 2019
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • Polypeptide display libraries and methods of making and using thereof
    Patent number: 10041063
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: August 7, 2018
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • Methods for Enhancing Bacterial Cell Display of Proteins and Peptides
    Publication number: 20180002687
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Application
    Filed: June 5, 2017
    Publication date: January 4, 2018
    Inventors: Patrick Sean Daugherty, Jeffrey Rice
  • Methods for enhancing bacterial cell display of proteins and peptides
    Patent number: 9695415
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: July 4, 2017
    Assignee: The Regents of the University of California
    Inventors: Patrick Sean Daugherty, Jeffrey Rice
  • Polypeptide Display Libraries and Methods of Making and Using Thereof
    Publication number: 20160032279
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Application
    Filed: August 7, 2015
    Publication date: February 4, 2016
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • Methods for Enhancing Bacterial Cell Display of Proteins and Peptides
    Publication number: 20160010082
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Application
    Filed: May 20, 2015
    Publication date: January 14, 2016
    Inventors: Patrick Sean Daugherty, Jeffrey Rice
  • Polypeptide display libraries and methods of making and using thereof
    Patent number: 9134309
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 15, 2015
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • Methods for enhancing bacterial cell display of proteins and peptides
    Patent number: 9062107
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: June 23, 2015
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Jeffrey Rice
  • Methods for Enhancing Bacterial Cell Display of Proteins and Peptides
    Publication number: 20150031855
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 29, 2015
    Inventors: PATRICK S. DAUGHERTY, Jeffrey Rice
  • Polypeptide display libraries and methods of making and using thereof
    Patent number: 8361933
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: January 29, 2013
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • Methods for enhancing bacterial cell display of proteins and peptides
    Patent number: 8293685
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: October 23, 2012
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Jeffrey Rice
  • Polypeptide Display Libraries and Methods of Making and Using Thereof
    Publication number: 20100113303
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Application
    Filed: September 21, 2009
    Publication date: May 6, 2010
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice
  • SYSTEMS AND KITS FOR PROMOTING AND MAINTAINING ORAL HEALTH
    Publication number: 20100035202
    Abstract: Systems and kits dispensing material and methods of forming and using the systems and kits are disclosed. The system may include a deformable vessel portion for storing material and a spout portion for directing the material as the material is dispensed from the system. The vessel portion and the spout portion may be formed separately and subsequently coupled together to form the system.
    Type: Application
    Filed: May 15, 2007
    Publication date: February 11, 2010
    Applicant: ZICARE, LLC
    Inventors: Tim Clarot, Regina Miskewitz, Samuel Belcher, Louis Germanio, JR., Jeffrey Rice
  • Polypeptide display libraries and methods of making and using thereof
    Patent number: 7612019
    Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: November 3, 2009
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Paul H. Bessette, Jeffrey Rice