Abstract: The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn's disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula: where R1, R2, R2?, R3, R4, X1, X2, X3, X4, Q, and n are described herein.

Abstract: The present disclosure relates to aerosol delivery devices, methods of forming such devices, and elements of such devices. In some embodiments, the present disclosure provides a heating member that can be formed of a heating element conformed to a heater substrate configured as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size. In some embodiments, the disclosure provides methods of forming an aerosol delivery device, which can include providing a shell, providing a heating member formed of a heating element conformed to a substrate, configuring the heating member as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size, and inserting the heating member within the shell.

Abstract: A harvesting vehicle includes a header having a cutter bar, a crop transport draper and a reel mounted above the cutter bar to sweep the crop to the draper. The operation of the header is autonomously monitored and controlled to reduce operator loads or to run autonomously by detecting: reel wrapping; differential rates of flow of crop on the header at different locations; where the crop to be cut is at least partly lodged so that stems of the crop are not vertical; the presence of a crop streak of uncut or poorly cut crop behind the cutter bar and/or a band of disturbed soil behind the cutter bar. The detector is arranged to control ground speed, header height, reel height and operation.

Abstract: Briefly, example methods, apparatuses, and/or articles of manufacture may be implemented, in whole or in part, to authenticate a communications device. In an embodiment, the method may include accessing a prepackaged group of computer instructions and invoking an authentication operation of the communications device. The method may additionally include determining availability of a cellular communications channel to communicate with a client server and initiating a browser session to pass hardware-specific parameters to and from the client server. The method may further include receiving an outcome of the authentication operation, in which invoking of the authentication operation and receiving the outcome of the authentication operation occur during a single exchange between a client application and the prepackaged group of computer instructions.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: An extrusion system, for example for extruding a food product, that includes: an extruder, which propels extrudate through an outlet of the extruder; and a valve. The valve includes: an inlet, which receives extrudate from the extruder outlet; a main conduit, which extends from the inlet to a main outlet; a dumping conduit, which extends from a junction with the main conduit to a dumping outlet; and a flow control member, which is operable to move between: a plurality of flow controlling positions, in which extrudate is directed to the main outlet, with the flow control member providing, for each flow controlling position, a respective amount of impedance to flow along the main conduit; and a flow diverting position, in which extrudate is directed along the dumping conduit to the dumping outlet.

Abstract: A resource-based authorization control may be added to a data processing service. A control-plane action requested by an account or entity creates a resource-based authorization policy. The resource-based authorization policy pertaining to respective resources allows recurrent data-plane actions to maintain a data flow in a data pipeline to be authorized independent of a separate authorization service.

Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.

Abstract: A system for interfacing with a decisioning service from a third-party domain. A backend system may receive a request to interface with the decisioning service to generate a prequalification result for a user for a specified product, in response to the actuation of a button included in a third-party web domain rendering a product. The backend system may execute a call on a website of the decisioning service. The backend system may receive the product information from the button. The backend system may generate the website within the third-party domain, including a request for information about the user, in response to executing the call to the website. The backend system may transmit a request for generating prequalification result for the product to the decisioning service. The backend system may receive the prequalification result from the decisioning service.

Abstract: A system and method for virtual block stick circuits is presented. The present disclosure implements specialized algorithms adapted to determine the true status of a virtual block based on multiple inputs from different perspectives. In one embodiment, the system can use the far house perspective of that virtual track segment and the PTC hazard for the near virtual track segment directly adjacent to the near house uses the near house perspective of that virtual track segment. For the middle virtual track segments, the near house perspectives of the middle virtual track segments are held ‘TRUE’ if they are already ‘TRUE’ when the train first enters the block, using stick circuits for the near house perspective of the middle track circuits. The vital application can then indicate the true state of the virtual track segment as occupied (FALSE), to protect the train from trains that follow.

Abstract: Described herein are examples of material removal machines with work tables separated by an air gap. In some examples. the air gap may provide space for a material removal tool of the material removal machine to extend between and substantially below the work tables to effect a deep cut on a workpiece that extends across the air gap. In some examples. a table actuator may be configured to move the work tables in tandem, allowing for the work tables and/or work piece to be moved to the material removal tool, rather than vice versa. Efficient design of the work tables and material removal machine ensures that the air gap between the work tables remains unobstructed all the way to a floor of the material removal machine. and ensures that the space underneath the work tables is sufficient for fluid/debris drainage and operator access.

Abstract: A surgical fastener applier including a housing containing a compartment, an elongated member extending distally from the housing, first and second jaws and a firing mechanism positioned within the housing. The firing mechanism is movable between a first position and a second position to effect firing of fasteners into the tissue clamped between the first and second jaws. A cover on the housing is openable to access the compartment. A power pack is removably loadable into the compartment, the power pack having a motor and an engagement member removably engageable with the firing mechanism within the compartment when the power pack is loaded into the compartment to effect movement of the firing mechanism from the first position to the second firing position.

Abstract: A device displays, in a first display region of a camera user interface, a first live view from a first camera. While displaying the first live view from the first camera, the device detects movement of a first user input (e.g., a first contact on a touch-sensitive surface). In accordance with a determination that the movement of the first user input meets first movement criteria, the device moves the first live view in the first display region in accordance with the movement of the first user input, displays a second live view from a second camera, and moves the second live view in the first display region in accordance with the movement of the first user input.

Abstract: The disclosed technology provides solutions for improving solar carport systems and in particular, for improving a solar carport integrated with a busbar. Aspects of the disclosed technology include an integrated solar carport that includes at least one beam, at least one rail coupled to the at least one beam, and one or more vertical columns configured to support the at least one beam and the at least one rail. Further, the integrated solar carport includes one or more solar modules coupled to the at least one beam or the at least one rail and a busbar coupled to each beam of the at least one beam and one of the vertical columns. Methods of manufacturing the integrated solar carport are also provided.

Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.

Abstract: Briefly, example methods, apparatuses, and/or articles of manufacture may be implemented, in whole or in part, using one or more computing devices to obtain, from a communications device, an identifier of the communications device transmitted via a communications network. The communications network may transmit a request for one or more parameters unique to a subscriber of the communications network. The method may also include processing signals indicative of the requested one or more parameters in response to the subscriber entering the one or more parameters into a graphical user interface of the communications device. The method may further include transmitting, to the communications device, one or more signals to provide a complement of subscriber parameters.

Abstract: Technology is disclosed herein to enable data transfer from unmanned aerial vehicles to cloud destinations. In an implementation, a relay resource in communication with a UAV sends a transfer request to a cloud service for managing data transfer for unmanned aerial vehicles. The request includes a unique identifier for the data file. The cloud service determines instructions for transferring the data file to a destination based on the file's unique identifier. The cloud service sends the transfer instructions to the relay resource via an API, the instructions including information for uploading the file to the destination.

Abstract: The present disclosure includes a split ring wire bundle seal sleeve and an assembly technology for pressurized electrical feedthroughs. A kit of parts is also described.

Abstract: Implementations relate to a multimodal translation application that can provide an abridged version of a translation through an audio interface of a computing device, while simultaneously providing a verbatim textual translation at a display interface of the computing device. The application can provide these different versions of the translation in certain circumstances when, for example, the rate of speech of a person speaking to a user is relatively high compared to a preferred rate of speech of the user. For example, a comparison between phonemes of an original language speech and a translated language speech can be performed to determine whether the ratio satisfies a threshold for providing an audible abridged translation. A determination to provide the abridged translation can additionally or alternatively be based on a determined language of the speaker.

Abstract: A computer generated voice can automatically be adapted to be similar to a user's voice. Various implementations include processing audio data capturing a first language spoken utterance to identify one or more pitch characteristics. For example, the one or more pitch characteristics can include an estimated frequency range of the given user's voice. Additionally or alternatively, the system can process the audio data capturing the first language spoken utterance and a set of candidate computer generated voices using a computer generated voice selection model to select a candidate computer generated voice. Various implementations can include automatically modifying the selected candidate computer generated voice based on the one or more pitch characteristics to change the frequency range of the modified computer generated voice based on the user's voice.