Abstract: A sample cartridge for a chemical processing instrument. The sample cartridge comprises a primary reaction vessel configured to accommodate a fluid sample for processing and configured to receive a lid for closing an open top of the primary reaction vessel, and a reagent vessel configured to receive one or more fluid reagents via an open top of the reagent vessel. The reagent vessel is connected to the primary reaction vessel via a primary reagent channel with a primary reagent valve disposed in the primary reagent channel to control fluid flow through the primary reagent channel. The sample cartridge further comprises a primary pneumatic port in fluid communication with the primary reaction vessel and configured to be connected to a pneumatic module to selectively adjust a pressure within the primary reaction vessel when the lid is closed to draw the fluid contents of the reagent vessel into the primary reaction vessel.

Abstract: Techniques are described for developing and using applications and skills with autonomous vehicles. In some embodiments, a development platform is provided that enables access to a developer console for developing software modules for use with autonomous vehicles. For example, a developer can specify instructions for causing an autonomous vehicle to perform one or more operations. To control the behavior of an autonomous vehicle, the instructions can cause an executing computer system at the autonomous vehicle to generate calls to an application programming interface (API) associated with an autonomous navigation system of autonomous vehicle. Such calls to the API can be configured to adjust parameters of a behavioral objective associated with a trajectory generation process performed by the autonomous navigation system that controls the behavior of the autonomous vehicle. The instructions specified by the developer can be packaged as a software module that can be deployed for use at autonomous vehicle.

Abstract: An assembly for display and storage, includes a main body with a top surface configured to present items, a bottom surface, and three side surfaces that define an internal cavity. The top surface may include at least one extendable platform that can transition between a stored position coplanar with the top surface and an open position extending laterally. Within the cavity, at least one height-adjustable shelf may be provided. The assembly may include a support that extends vertically from the main body, holding an adjustable signage assembly, which may be digital and remotely updatable.

Abstract: Methods, devices, and systems are described for a mounting flange and bracket for a space habitat. The bracket system couples a bladder of a space habitat to a cylindrical core. The bracket system includes a soft goods layer configured to cover the bladder of the space habitat. The bracket system includes a mounting flange configured to couple at an end of the cylindrical core. The mounting flange includes a lip extending around the mounting flange. The bracket system includes a bracket configured to connect the soft goods layer to the mounting flange. The bracket has a first end and a second end. The first end includes a pin configured to couple to the soft goods layer. The second end includes a protrusion configured to latch to the lip of the mounting flange. In some variations, a cap is configured to be coupled to the outer side of the mounting flange.

Abstract: An extrusion system, for example for extruding a food product, that includes: an extruder, which propels extrudate through an outlet of the extruder; and a valve. The valve includes: an inlet, which receives extrudate from the extruder outlet; a main conduit, which extends from the inlet to a main outlet; a dumping conduit, which extends from a junction with the main conduit to a dumping outlet; and a flow control member, which is operable to move between: a plurality of flow controlling positions, in which extrudate is directed to the main outlet, with the flow control member providing, for each flow controlling position, a respective amount of impedance to flow along the main conduit; and a flow diverting position, in which extrudate is directed along the dumping conduit to the dumping outlet.

Abstract: Methods, devices, and systems are described for a bracket fixture for securing a load to a soft goods layer in a space habitat. The bracket fixture includes a base having a plurality of sides, the plurality of sides having a pin parallel to its respective side, and an aperture between the pin and the respective side. The bracket fixture further includes a protrusion extending from the base, the protrusion including a fixture element.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: A container for transporting or preserving a biological material includes a bag member that includes a first layer having a peripheral edge and a second layer having a peripheral edge. The peripheral edge of the first layer is adjoined to the peripheral edge of the second layer around a circumference, with a phase change material between the first layer and the second layer. The bag member may further include a sealed first end and an opening defined in a second end. The bag member is configured to receive and hold the biological material.

Abstract: A device includes a deployment channel having a distal port and a proximal end disposed along a longitudinal axis. The device includes an actuator coupled to the deployment channel. The actuator is coupled to a pushrod disposed within a pushrod channel and aligned with the deployment channel. The pushrod is axially repositionable between a retract position and an eject position. A position of the pushrod relative to the pushrod channel is determined by the actuator.

Abstract: Responsive to a magnitude of current associated with power from a vehicle being supplied to loads having a same priority approaching or exceeding a predefined threshold and indication that one of the loads has not been present at a same time as other of the loads, one or more controllers may shed or operate with reduced power the one of the loads before shedding or operating with reduced power the other of the loads.

Abstract: While a state of charge of a supplemental battery, that provides power to an electrical bus via a first DC/DC converter, is greater than a predefined threshold and responsive to a magnitude of current associated with loads on the electrical bus exceeding a predefined value, a controller reduces a setpoint of the first DC/DC converter to equal that of a second DC/DC converter, that transfers power between the electrical bus and a traction battery, such that the loads are powered by the supplemental and traction batteries.

Abstract: Feature pyramiding for in situ data visualizations is provided. In various embodiments, a point cloud is loaded. Each point within the point cloud represents a feature of a biological sample at its corresponding location. At least one tile is determined having a two-dimensional area and a zoom level. Those points having a location within the two-dimensional area are selected from the point cloud. Based on the selected points and the zoom level, a set of display points is determined, each point of the set of display point representing a feature of the biological sample at its corresponding location. The set of display points is provided for display at the zoom level.

Abstract: In some embodiments, an electronic device optionally identifies a person's face, and optionally performs an action in accordance with the identification. In some embodiments, an electronic device optionally determines a gaze location in a user interface, and optionally performs an action in accordance with the determination. In some embodiments, an electronic device optionally designates a user as being present at a sound-playback device in accordance with a determination that sound-detection criteria and verification criteria have been satisfied. In some embodiments, an electronic device optionally determines whether a person is further or closer than a threshold distance from a display device, and optionally provides a first or second user interface for display on the display device in accordance with the determination. In some embodiments, an electronic device optionally modifies the playing of media content in accordance with a determination that one or more presence criteria are not satisfied.

Abstract: An electronic device manufacturing system includes a mainframe including a transfer chamber and facets defining side walls of the transfer chamber. The facets include first facet, second facet, third facet, and fourth facet that form the transfer chamber. The first facet has a first number of substrate access ports. The second facet has a second number of substrate access ports. A first substrate access port of the first facet has a first side dimension and a second substrate access port of the second facet has a second side dimension that is different from the first side dimension. The second facet is adjacent to the first facet. The third facet is adjacent to the second facet. The fourth facet has the second number of substrate access ports. The second number of substrate access ports is different than the first number of substrate access ports.

Abstract: Described herein are novel and improved antibodies that bind human fibrin or fibrinogen ?C domain and methods of use thereof. In certain aspects, described herein are methods of inhibiting microglial activation. In certain aspects, described herein are pharmaceutical compositions comprising the antibodies that bind fibrin or fibrinogen ?C domain. In certain aspects, the antibodies and methods described herein are used for treatment of degenerative neuronal disorders that involve inflammatory demyelination.

Abstract: Systems and methods for generating a video of a user-defined virtual reality scene are disclosed. Exemplary implementations may: obtain a scene definition; obtain camera information for multiple virtual cameras to be used in generating a two-dimensional presentation of the virtual reality scene; execute a simulation of the virtual reality scene from the scene definition for at least a portion of the scene duration; obtain camera timing instructions specifying which of the virtual cameras should be used to generate the two-dimensional presentation of the virtual reality scene as a function of progress through the scene duration; generate the two-dimensional presentation of the virtual reality scene in accordance with the camera timing instructions and the camera information.

Abstract: A system and a method for connecting a vehicle to an external source includes determining that a vehicle to be propelled by a drive system having one or more motors is to connect to an off-board power source while the one or more motors are powered by an onboard power source. The onboard power source is controlled to provide a determined amount of first electric energy to a first converter system. A second converter system is controlled to output an amount of second electric energy from the off-board power source within a designated threshold range. The second converter system is disposed between the off-board power source and the first converter system. The drive system receives power from the off-board power source responsive to the second converter system outputting the second amount of electric energy within the designated threshold range.

Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: The present disclosure generally relates to interacting with an electronic device without touching a display screen or other physical input mechanisms. In some examples, the electronic device performs an operation in response to a positioning of a user's hand and/or an orientation of the electronic device.

Abstract: An electronic device has multiple cameras and displays a digital viewfinder user interface for previewing visual information provided by the cameras. The multiple cameras may have different properties such as focal lengths. When a single digital viewfinder is provided, the user interface allows zooming over a zoom range that includes the respective zoom ranges of both cameras. The zoom setting to determine which camera provides visual information to the viewfinder and which camera is used to capture visual information. The user interface also allows the simultaneous display of content provided by different cameras at the same time. When two digital viewfinders are provided, the user interface allows zooming, freezing, and panning of one digital viewfinder independently of the other. The device allows storing of a composite images and/or videos using both digital viewfinders and corresponding cameras.