Abstract: Feature pyramiding for in situ data visualizations is provided. In various embodiments, a point cloud is loaded. Each point within the point cloud represents a feature of a biological sample at its corresponding location. At least one tile is determined having a two-dimensional area and a zoom level. Those points having a location within the two-dimensional area are selected from the point cloud. Based on the selected points and the zoom level, a set of display points is determined, each point of the set of display point representing a feature of the biological sample at its corresponding location. The set of display points is provided for display at the zoom level.

Abstract: Described herein are novel and improved antibodies that bind human fibrin or fibrinogen ?C domain and methods of use thereof. In certain aspects, described herein are methods of inhibiting microglial activation. In certain aspects, described herein are pharmaceutical compositions comprising the antibodies that bind fibrin or fibrinogen ?C domain. In certain aspects, the antibodies and methods described herein are used for treatment of degenerative neuronal disorders that involve inflammatory demyelination.

Abstract: In some embodiments, an electronic device optionally identifies a person's face, and optionally performs an action in accordance with the identification. In some embodiments, an electronic device optionally determines a gaze location in a user interface, and optionally performs an action in accordance with the determination. In some embodiments, an electronic device optionally designates a user as being present at a sound-playback device in accordance with a determination that sound-detection criteria and verification criteria have been satisfied. In some embodiments, an electronic device optionally determines whether a person is further or closer than a threshold distance from a display device, and optionally provides a first or second user interface for display on the display device in accordance with the determination. In some embodiments, an electronic device optionally modifies the playing of media content in accordance with a determination that one or more presence criteria are not satisfied.

Abstract: An electronic device manufacturing system includes a mainframe including a transfer chamber and facets defining side walls of the transfer chamber. The facets include first facet, second facet, third facet, and fourth facet that form the transfer chamber. The first facet has a first number of substrate access ports. The second facet has a second number of substrate access ports. A first substrate access port of the first facet has a first side dimension and a second substrate access port of the second facet has a second side dimension that is different from the first side dimension. The second facet is adjacent to the first facet. The third facet is adjacent to the second facet. The fourth facet has the second number of substrate access ports. The second number of substrate access ports is different than the first number of substrate access ports.

Abstract: Systems and methods for generating a video of a user-defined virtual reality scene are disclosed. Exemplary implementations may: obtain a scene definition; obtain camera information for multiple virtual cameras to be used in generating a two-dimensional presentation of the virtual reality scene; execute a simulation of the virtual reality scene from the scene definition for at least a portion of the scene duration; obtain camera timing instructions specifying which of the virtual cameras should be used to generate the two-dimensional presentation of the virtual reality scene as a function of progress through the scene duration; generate the two-dimensional presentation of the virtual reality scene in accordance with the camera timing instructions and the camera information.

Abstract: A system and a method for connecting a vehicle to an external source includes determining that a vehicle to be propelled by a drive system having one or more motors is to connect to an off-board power source while the one or more motors are powered by an onboard power source. The onboard power source is controlled to provide a determined amount of first electric energy to a first converter system. A second converter system is controlled to output an amount of second electric energy from the off-board power source within a designated threshold range. The second converter system is disposed between the off-board power source and the first converter system. The drive system receives power from the off-board power source responsive to the second converter system outputting the second amount of electric energy within the designated threshold range.

Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: The present disclosure generally relates to interacting with an electronic device without touching a display screen or other physical input mechanisms. In some examples, the electronic device performs an operation in response to a positioning of a user's hand and/or an orientation of the electronic device.

Abstract: A computer system displays virtual objects overlaid on a view of a physical environment as a virtual effect. The computer system displays respective animated movements of the virtual objects over the view of the physical environment, wherein the respective animated movements are constrained in accordance with a direction of simulated gravity associated with the view of the physical environment. If current positions of virtual objects during the respective animated movement of the virtual objects corresponds to different surfaces at different heights detected in the view of the physical environment, the computer constrains the respective animated movements of the virtual objects in accordance with the different surfaces detected in the view of the physical environment.

Abstract: An electronic device has multiple cameras and displays a digital viewfinder user interface for previewing visual information provided by the cameras. The multiple cameras may have different properties such as focal lengths. When a single digital viewfinder is provided, the user interface allows zooming over a zoom range that includes the respective zoom ranges of both cameras. The zoom setting to determine which camera provides visual information to the viewfinder and which camera is used to capture visual information. The user interface also allows the simultaneous display of content provided by different cameras at the same time. When two digital viewfinders are provided, the user interface allows zooming, freezing, and panning of one digital viewfinder independently of the other. The device allows storing of a composite images and/or videos using both digital viewfinders and corresponding cameras.

Abstract: The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn's disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula: where R1, R2, R2?, R3, R4, X1, X2, X3, X4, Q, and n are described herein.

Abstract: The present disclosure relates to aerosol delivery devices, methods of forming such devices, and elements of such devices. In some embodiments, the present disclosure provides a heating member that can be formed of a heating element conformed to a heater substrate configured as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size. In some embodiments, the disclosure provides methods of forming an aerosol delivery device, which can include providing a shell, providing a heating member formed of a heating element conformed to a substrate, configuring the heating member as a truncated cone (or similar shape) having a first end of a first size and a second end of greater size, and inserting the heating member within the shell.

Abstract: A harvesting vehicle includes a header having a cutter bar, a crop transport draper and a reel mounted above the cutter bar to sweep the crop to the draper. The operation of the header is autonomously monitored and controlled to reduce operator loads or to run autonomously by detecting: reel wrapping; differential rates of flow of crop on the header at different locations; where the crop to be cut is at least partly lodged so that stems of the crop are not vertical; the presence of a crop streak of uncut or poorly cut crop behind the cutter bar and/or a band of disturbed soil behind the cutter bar. The detector is arranged to control ground speed, header height, reel height and operation.

Abstract: Briefly, example methods, apparatuses, and/or articles of manufacture may be implemented, in whole or in part, to authenticate a communications device. In an embodiment, the method may include accessing a prepackaged group of computer instructions and invoking an authentication operation of the communications device. The method may additionally include determining availability of a cellular communications channel to communicate with a client server and initiating a browser session to pass hardware-specific parameters to and from the client server. The method may further include receiving an outcome of the authentication operation, in which invoking of the authentication operation and receiving the outcome of the authentication operation occur during a single exchange between a client application and the prepackaged group of computer instructions.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: An extrusion system, for example for extruding a food product, that includes: an extruder, which propels extrudate through an outlet of the extruder; and a valve. The valve includes: an inlet, which receives extrudate from the extruder outlet; a main conduit, which extends from the inlet to a main outlet; a dumping conduit, which extends from a junction with the main conduit to a dumping outlet; and a flow control member, which is operable to move between: a plurality of flow controlling positions, in which extrudate is directed to the main outlet, with the flow control member providing, for each flow controlling position, a respective amount of impedance to flow along the main conduit; and a flow diverting position, in which extrudate is directed along the dumping conduit to the dumping outlet.

Abstract: A resource-based authorization control may be added to a data processing service. A control-plane action requested by an account or entity creates a resource-based authorization policy. The resource-based authorization policy pertaining to respective resources allows recurrent data-plane actions to maintain a data flow in a data pipeline to be authorized independent of a separate authorization service.

Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.

Abstract: A system for interfacing with a decisioning service from a third-party domain. A backend system may receive a request to interface with the decisioning service to generate a prequalification result for a user for a specified product, in response to the actuation of a button included in a third-party web domain rendering a product. The backend system may execute a call on a website of the decisioning service. The backend system may receive the product information from the button. The backend system may generate the website within the third-party domain, including a request for information about the user, in response to executing the call to the website. The backend system may transmit a request for generating prequalification result for the product to the decisioning service. The backend system may receive the prequalification result from the decisioning service.

Abstract: Described herein are examples of material removal machines with work tables separated by an air gap. In some examples. the air gap may provide space for a material removal tool of the material removal machine to extend between and substantially below the work tables to effect a deep cut on a workpiece that extends across the air gap. In some examples. a table actuator may be configured to move the work tables in tandem, allowing for the work tables and/or work piece to be moved to the material removal tool, rather than vice versa. Efficient design of the work tables and material removal machine ensures that the air gap between the work tables remains unobstructed all the way to a floor of the material removal machine. and ensures that the space underneath the work tables is sufficient for fluid/debris drainage and operator access.