Patents by Inventor Jeffrey S. Grimm

Jeffrey S. Grimm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 9359327
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: June 7, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 9079882
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: July 14, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 9079884
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: July 14, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 9079883
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 14, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 9006432
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: April 14, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Daniel J. Pippel
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Patent number: 8835633
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: September 16, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Tong Xiao, Diego Broggini, Susanne Lochner
  • PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIMIDINE DERIVATIVES
    Publication number: 20140121374
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 1, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Daniel J. Pippel
  • Process for the preparation of piperazinyl and diazepanyl benzamide derivatives
    Patent number: 8680273
    Abstract: The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: March 25, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Anusuya Choudhury, Jeffrey S. Grimm, Kirk L. Sorgi, David Palmer, Jing Liu
  • Process for the preparation of substituted pyrimidine derivatives
    Publication number: 20140073795
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 13, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Publication number: 20140066624
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Application
    Filed: November 11, 2013
    Publication date: March 6, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of substituted pyrimidine derivatives
    Patent number: 8309720
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: November 13, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Publication number: 20120184740
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 19, 2012
    Inventors: Sergio Cesco-Cancian, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Tong Xiao, Diego Broggini, Susanne Lochner
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatgives
    Publication number: 20120178932
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 12, 2012
    Inventors: Sergio CESCO-CANCIAN, Jeffrey S. GRIMM, Neelakandha S. MANI, Christopher M. MAPES, David C. PALMER, Daniel J. PIPPEL, Tong XIAO, Diego BROGGINI, Susanne LOCHNER
  • PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES
    Publication number: 20110105752
    Abstract: The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.
    Type: Application
    Filed: January 10, 2011
    Publication date: May 5, 2011
    Inventors: Anusuya Choudhury, Jeffrey S. Grimm, Kirk L. Sorgi, David Palmer, Jing Liu
  • Process for the preparation of piperazinyl and diazepanyl benzamide derivatives
    Patent number: 7893257
    Abstract: The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: February 22, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Anusuya Choudhury, Jeffrey S. Grimm, Kirk L. Sorgi, David Palmer, Jing Liu
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Publication number: 20100029942
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: June 29, 2009
    Publication date: February 4, 2010
    Inventors: Sergio Cesco-Cancian, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Tong Xiao, Diego Broggini, Susanne Lochner
  • Process for the preparation of substituted pyrimidine derivatives
    Publication number: 20100004450
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Application
    Filed: June 29, 2009
    Publication date: January 7, 2010
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES
    Publication number: 20080171870
    Abstract: The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.
    Type: Application
    Filed: December 10, 2007
    Publication date: July 17, 2008
    Inventors: Anusuya Choudhury, Jeffrey S. Grimm, Kirk L. Sorgi, David Palmer, Jing Liu
  • One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols
    Publication number: 20080009628
    Abstract: One-pot condensation-reduction methods for preparing substituted allylic alcohols as well as highly selective extractive methods to separate isomeric alcohols produced in the one-pot condensation-reduction processes are provided for preparing, for example, a quinolone.
    Type: Application
    Filed: June 13, 2007
    Publication date: January 10, 2008
    Inventors: Michael Reuman, Roger Faessler, Armin Roessler, Kirk Sorgi, Xun Li, Jeffrey S. Grimm