Patents by Inventor Jeffrey S. Kiel

Jeffrey S. Kiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7550628
    Abstract: The present invention provides a novel process for preparation of the tannate salt of gabapentin for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. However, the prior art neither discloses nor suggests the preparation of gabapentin tannate. The process for preparing gabapentin tannate includes the mixing of gabapentin and tannic acid together in the presence of one or more solvents. The method may further include the step of selecting the one or more solvents from a group consisting of purified water, ethanol, glycerin, propylene glycol, diethylether, methylene chloride, acetone, isopropyl alcohol and mixtures thereof. The process may also include the steps of isolating and purifying the tannate salt. This may be accomplished by filtration, drying, centrifugation and lyophilization. The process may utilize either natural or synthetic tannic acid.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: June 23, 2009
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20090149815
    Abstract: Medication dosing system for one or more medications based on patient classification codes and standardized dosage units, where the patient classification codes are correlated with one or more characteristics of the patient, such as weight or age, and each medication is formulated so that the dosage unit for the classification code contains the recommended amount of medication for patients within that classification code.
    Type: Application
    Filed: December 11, 2008
    Publication date: June 11, 2009
    Inventors: Jeffrey S. Kiel, H. Greg Thomas
  • Publication number: 20090062191
    Abstract: The invention relates to a suspension of albumin and tannic acid for maintaining gastrointestinal homeostasis.
    Type: Application
    Filed: August 29, 2007
    Publication date: March 5, 2009
    Inventors: Jeffrey S. Kiel, H. Gregory Thomas, Richard Andrew Todebush
  • Patent number: 7456312
    Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: November 25, 2008
    Assignee: Kiel Laborities, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20080242728
    Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
    Type: Application
    Filed: June 13, 2008
    Publication date: October 2, 2008
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 7390922
    Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention provides a novel process for preparation of the tannate salt of gabapentin in liquid or semi-solid dosage form for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: June 24, 2008
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20080125453
    Abstract: Compositions of tannate salts of phenylephrine, pyrilamine, and dextromethorphan produced by a method that allows for the in-situ conversions and incorporation of the tannate salts in a single dosage form. The conversion process includes dissolving salts of phenylephrine, pyrilamine, and dextromethorphan in a solvent and mixing with a dispersing agent and tannic acid to generate tannate salts. The tannate salts may be further processed without further purification or isolation to single dosage forms, such as tablets and suspension.
    Type: Application
    Filed: February 8, 2008
    Publication date: May 29, 2008
    Applicant: TIBER LABORATORIES, LLC
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 7273623
    Abstract: An active pharmaceutical ingredient is combined with tannic acid to form a tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then blended with pharmaceutically acceptable excipients to form a granulate which is processed into a tablet or capsule to generate a therapeutic solid dosage form.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: September 25, 2007
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 7094429
    Abstract: An active ingredient from the group of an antihistamine, a decongestant, an antitussive or anticholinergic is dissolved in a suitable solvent and added to a dispersion of tannic acid in water to form the tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then added to a liquid or semi-solid medium composed of thickening, suspending, coloring, sweetening and flavoring agents, with stirring. Thereafter, preservatives, pH-adjusting and anti-caking agents in a suitable solvent are mixed with the liquid or semi-solid medium to generate a therapeutic dosage form.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: August 22, 2006
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 6869618
    Abstract: An active ingredient from the group of an antihistamine, a decongestant, an antitussive or anticholinergic is dissolved in a suitable solvent and added to a dispersion of tannic acid in water to form the tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then added to a liquid or semi-solid medium composed of thickening, suspending, coloring, sweetening and flavoring agents, with stirring. Thereafter, preservatives, pH-adjusting and anti-caking agents in a suitable solvent are mixed with the liquid or semi-solid medium to generate a therapeutic dosage form.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: March 22, 2005
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20040234593
    Abstract: A therapeutic composition comprises diphenhydramine tannate in the substantial absence of other active ingredients. The composition has utility in providing symptomatic relief of sneezing, itchy, watery eyes, itchy nose or throat and runny nose due to hay fever (allergic rhinitis) or other respiratory allergies.
    Type: Application
    Filed: March 5, 2004
    Publication date: November 25, 2004
    Inventors: Jeffrey S Kiel, H Greg Thomas, Narasimhan Mani
  • Publication number: 20040192618
    Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention provides a novel process for preparation of the tannate salt of gabapentin in liquid or semi-solid dosage form for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
    Type: Application
    Filed: March 22, 2004
    Publication date: September 30, 2004
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20040192617
    Abstract: The present invention provides a novel process for preparation of the tannate salt of gabapentin for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. However, the prior art neither discloses nor suggests the preparation of gabapentin tannate. The process for preparing gabapentin tannate includes the mixing of gabapentin and tannic acid together in the presence of one or more solvents. The method may further include the step of selecting the one or more solvents from a group consisting of purified water, ethanol, glycerin, propylene glycol, diethylether, methylene chloride, acetone, isopropyl alcohol and mixtures thereof. The process may also include the steps of isolating and purifying the tannate salt. This may be accomplished by filtration, drying, centrifugation and lyophilization. The process may utilize either natural or synthetic tannic acid.
    Type: Application
    Filed: March 22, 2004
    Publication date: September 30, 2004
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20040192616
    Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
    Type: Application
    Filed: March 22, 2004
    Publication date: September 30, 2004
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20040132827
    Abstract: Compositions of tannate salts of phenylephrine, pyrilamine, and dextromethorphan produced by a method that allows for the in-situ conversion and incorporation of the tannate salts in a single dosage form. The conversion process includes dissolving salts of phenylephrine, pyrilamine, and dextromethorphan in a solvent and mixing with a dispersing agent and tannic acid to generate tannate salts. The tannate salts may be further processed without further purification or isolation to single dosage forms, such as tablets and suspension.
    Type: Application
    Filed: August 22, 2003
    Publication date: July 8, 2004
    Applicant: PediaMed Pharmaceuticals, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20030083354
    Abstract: Compositions of tannate salts of phenylephrine and pyrilamine produced by a method that allows for the in-situ conversion and incorporation of the tannate salts in a single dosage form. The conversion process includes dissolving a salts of phenylephrine and pyrilamine in a solvent and mixing with a dispersing agent and tannic acid to generate tannate salts. The tannate salts may be further processed to single dosage forms, such as tablets and suspensions.
    Type: Application
    Filed: October 26, 2001
    Publication date: May 1, 2003
    Applicant: PediaMed Pharmaceuticals, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20030077321
    Abstract: An active pharmaceutical ingredient is combined with tannic acid to form a tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then blended with pharmaceutically acceptable excipients to form a granulate which is processed into a tablet or capsule to generate a therapeutic solid dosage form.
    Type: Application
    Filed: October 10, 2002
    Publication date: April 24, 2003
    Applicant: KIEL LABORATORIES, INC.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20030050252
    Abstract: An active ingredient from the group of an antihistamine, a decongestant, an antitussive or anticholinergic is dissolved in a suitable solvent and added to a dispersion of tannic acid in water to form the tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then added to a liquid or semi-solid medium composed of thickening, suspending, coloring, sweetening and flavoring agents, with stirring. Thereafter, preservatives, pH-adjusting and anti-caking agents in a suitable solvent are mixed with the liquid or semi-solid medium to generate a therapeutic dosage form.
    Type: Application
    Filed: April 9, 2002
    Publication date: March 13, 2003
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 6350724
    Abstract: The present invention provides a composition, and a method of use thereof, that is pesticide-free and yet is capable of cleansing an individual of a pest infestation. The composition of the present invention consists essentially of an acid, an alcohol, an aqueous detergent and water. The composition is used in the removal of pests and their ova from infested individuals. Preferably, the composition of the present invention takes the form of a shampoo and is used to cleanse individuals of lice infestations. In use, the composition is applied to hair and allowed to remain in contact with the hair and scalp for a period of time, called the residence time. After the residence time, the composition is rinsed from the hair. Then, the hair is combed with a suitable nit comb. These treatment steps may be repeated as necessary and appropriate to effectuate the removal of the pest infestation.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: February 26, 2002
    Assignee: Effcon Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, Jeffrey H. Ping
  • Patent number: 6214381
    Abstract: A pharmaceutical composition useful for treating ocular conditions, such as glaucoma. In particular, the pharmaceutical composition is a sustained release oral dosage composition for relieving intraocular pressure comprising methazolamide and a high molecular weight binder, wherein the composition provides sustained rate of methazolamide release in an in vitro drug release profile. A filler and a lubricant may also be included.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: April 10, 2001
    Assignee: Effcon, Inc.
    Inventors: Eddie R. Burklow, Jeffrey S. Kiel, Jeffrey H. Ping