Abstract: An anti-CLEC12A polypeptide generally includes an amino acid sequence having at least 90% amino acid similarity to SEQ ID NO:14. In some embodiments, anti-CLEC12A polypeptide may be incorporated into an anti-CLEC12A biologic. In some of these embodiments, the anti-CLEC12A biologic can be a bi-specific Killer engager molecule (BiKE), a tri-specific Killer engager molecule (TriKE), a tetra-specific Killer engager molecule (TetraKE), a penta-specific Killer engager molecule (PentaKE), a bi-specific T cell engager molecule (BiTE), a tri-specific T cell engager molecule (TriTE), tetra-specific T cell engager molecule (TetraTE), a penta-specific T cell engager molecule (PentaTE), a chimeric antigen receptor, a full antibody, an antibody-drug conjugate (ADC) molecule, a targeted delivery construct, or a labeling construct.

Abstract: Multispecific B7H3 targeting compounds and methods of use thereof are provided. The multispecific compounds include bispecific targeting proteins including a B7H3 targeting domain and an immune cell engaging domain; and trispecific targeting proteins including a B7H3 targeting domain, an immune cell engaging domain and an immune cell activating domain. The methods of use include methods of inducing NK-mediates cell killing, methods of inducing NK expansion in vivo, and methods of treating cancer.

Abstract: This disclosure describes compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain. In an illustrative embodiment, the targeting domain selectively binds to an HIV antigen.

Abstract: An immunotherapy compound includes an NK cell engaging domain, an NK activating domain and a targeting domain. The targeting domain selectively binds to HER2, HERS, or the HER2/HER3 heterodimer complex and is operably linked to the NK activating domain and the NK cell engaging domain. The compound may be administered to a subject to induce NK-mediated killing of a cancer cell, to stimulate expansion of NK cells in the subject, and/or for treating cancer.

Abstract: This disclosure describes engineered compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain.

Abstract: Provided are compositions for activating NK cells to stimulate an immune response for treating cancer and other disorders. In one embodiment, the invention provides a compound comprising an NK engaging domain that binds to CD 16; an NK activating domain operably linked to the NK engaging domain; and a targeting domain that selectively binds to a target cell and is operably linked to the NK activating domain and the NK engaging domain, wherein the targeting domain binds to CLEC12A.

Abstract: This disclosure describes engineered compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain.

Abstract: This disclosure describes engineered compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain.

Abstract: This disclosure describes engineered compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain.

Abstract: This disclosure describes engineered compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain.

Abstract: A host application executing on a client device includes a content processing extension that extends its functionality to process content items to a requesting host application executing on a client device. The content processing extension is an executable file that includes data conversion code and application code. The data conversion code, when executed in requesting host application, identifies content items provided by the requesting host application and formats the identified content items to be received by the content processing extension. The application code is native code executable by the host application associated with the content processing extension. The application code processes the results from execution of the data conversion and the identified content items in accordance with one or more functions of the host application, and returns the processed content items to the requesting host application via the content processing extension.

Abstract: This disclosure describes engineered compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain.

Abstract: The presently disclosed techniques related to data transfer and synchronization between multiple electronic devices. The multiple electronic devices may be logged onto a user's account with a cloud computing service so that they may transfer data relating to websites that they have accessed to the cloud computing service so that such data may be synchronized amongst the multiple electronic devices. A tab screen on each electronic device may allow a user to view the other linked devices as well as the websites that they have accessed so that the user may select such websites if so desired.

Abstract: This document describes techniques and apparatuses enabling an application-launching interface for multiple modes. This interface enables a user to quickly and easily select to launch applications associated with different modes. A user may avoid wading through multiple interfaces, making multiple selections, and/or a cognitive load associated with deciding on a mode with which to interact.

Abstract: The presently disclosed techniques related to data transfer and synchronization between multiple electronic devices. The multiple electronic devices may be logged onto a user's account with a cloud computing service so that they may transfer data relating to websites that they have accessed to the cloud computing service so that such data may be synchronized amongst the multiple electronic devices. A tab screen on each electronic device may allow a user to view the other linked devices as well as the websites that they have accessed so that the user may select such websites if so desired.

Abstract: A host application executing on a client device includes a content processing extension that extends its functionality to process content items to a requesting host application executing on a client device. The content processing extension is an executable file that includes data conversion code and application code. The data conversion code, when executed in requesting host application, identifies content items provided by the requesting host application and formats the identified content items to be received by the content processing extension. The application code is native code executable by the host application associated with the content processing extension. The application code processes the results from execution of the data conversion and the identified content items in accordance with one or more functions of the host application, and returns the processed content items to the requesting host application via the content processing extension.

Abstract: This document describes techniques and apparatuses enabling an application-launching interface for multiple modes. This interface enables a user to quickly and easily select to launch applications associated with different modes. A user may avoid wading through multiple interfaces, making multiple selections, and/or a cognitive load associated with deciding on a mode with which to interact.

Abstract: This document describes techniques and apparatuses enabling an application-launching interface for multiple modes. This interface enables a user to quickly and easily select to launch applications associated with different modes. A user may avoid wading through multiple interfaces, making multiple selections, and/or a cognitive load associated with deciding on a mode with which to interact.

Abstract: System, method and computer program for facilitating media playlist generation based at least in part on media library inventory information provided by a plurality of program participants. Data is transmitted from a program participant's client device indicative of media inventory in a media library of the program participant. Media item similarity ratings are received at the client device that have been compiled based on cumulative data collected from a plurality of program participants, including identification data of individual media items contained in media libraries of the program participants regardless of each individual media item's source. Similarity ratings compilation includes processing the cumulative data to determine an incidence of co-occurrence of pairs of individual media items in different program participants' media libraries and making an assignment of a similarity rating based on the determined incidence of co-occurrence.

Abstract: System, method and computer program that encompasses one or more client devices cooperating with a program host's on-line data processing center to generate media playlists. Data is transmitted from a program participant's client device to the processing center and is representative of media inventory in a media library on the client device and includes identification data of contained individual media items. Data is further received from a plurality of program participants representative of each respective program participant's media inventory, regardless of the source of the members of the inventory. Co-occurrence of pairs of individual media items in different program participants' media libraries is determined and a similarity rating is assigned between the pairs of individual media items based on the determined incidence of co-occurrence in the different program participants' media libraries. From this, a media playlist is generated.