Patents by Inventor Jeffrey S. SWERS

Jeffrey S. SWERS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250154224
    Abstract: D domain (DD) containing polypeptides (DDpp) that specifically bind targets of interest (e.g., BCMA, CD123, CS1, HER2, AFP, and AFP p26) are provided, as are nucleic acids encoding the DDpp, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. DDpp such as DDpp fusion proteins, are also provided as are methods of making and using the DDpp. Such uses include, but are not limited to diagnostic and therapeutic applications.
    Type: Application
    Filed: January 17, 2025
    Publication date: May 15, 2025
    Inventors: David M. HILBERT, Jeffrey S. SWERS
  • Publication number: 20250026849
    Abstract: Provided herein are multi-functional chimeric antigen receptor (CAR)-based compositions and their use in directing immune responses to target cells. The compositions have uses that include treating hyperproliferative disorders such as cancer. The provided methods generally include the use of a CAR cell in combination with an Adapter. The Adapter confers the ability to modulate, alter, and/or redirect CAR cell-mediated immune response in vitro and in vivo.
    Type: Application
    Filed: August 26, 2024
    Publication date: January 23, 2025
    Inventors: David M. HILBERT, Jeffrey S. SWERS, David William LAFLEUR
  • Publication number: 20240156866
    Abstract: Provided herein are multi-functional chimeric antigen receptor (CAR)-based compositions and their use in directing immune responses to target cells. The compositions have uses that include treating hyperproliferative disorders such as cancer. The provided methods generally include the use of a CAR cell in combination with an Adapter. The Adapter confers the ability to modulate, alter, and/or redirect CAR cell-mediated immune response in vitro and in vivo. In some embodiments, the CAR cell comprises a genetic modification to reduce or eliminate the expression of a targeted antigenic determinant.
    Type: Application
    Filed: June 28, 2023
    Publication date: May 16, 2024
    Inventors: David M. HILBERT, Jeffrey S. SWERS, David William LAFLEUR
  • Publication number: 20230250185
    Abstract: Provided herein are D domain containing polypeptides that specifically bind targets of interest, as are nucleic acids encoding the D domain containing polypeptides, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. Also provided herein are methods of making and using the D domain containing polypeptides, nucleic acids, vectors and host cells, for example, but not limitefd to, in diagnostic and therapeutic applications. Also provided herein are multi-functional chimeric antigen receptor (CAR)-based compositions and Adapters and their use in methods of directing immune responses to target cells. In some embodiments, the methods include the use of a CAR expressing cell in combination with an Adapter. The Adapter confers the ability to modulate, alter, and/or direct CAR expressing cell-mediated immune response in vitro and in vivo.
    Type: Application
    Filed: November 14, 2022
    Publication date: August 10, 2023
    Inventors: David LAFLEUR, Jeffrey S. SWERS, Justin EDWARDS
  • Publication number: 20230125550
    Abstract: D domain (DD) containing polypeptides (DDpp) that specifically bind targets of interest (e.g., BCMA, CD123, CS1, HER2, AFP, and AFP p26) are provided, as are nucleic acids encoding the DDpp, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. DDpp such as DDpp fusion proteins, are also provided as are methods of making and using the DDpp. Such uses include, but are not limited to diagnostic and therapeutic applications.
    Type: Application
    Filed: September 28, 2022
    Publication date: April 27, 2023
    Inventors: David M. HILBERT, Jeffrey S. SWERS
  • Publication number: 20220056105
    Abstract: D domain (DD) containing polypeptides (DDpp) that specifically bind targets of interest (e.g., BCMA, CD123, CS1, HER2, AFP, and AFP p26) are provided, as are nucleic acids encoding the DDpp, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. DDpp such as DDpp fusion proteins, are also provided as are methods of making and using the DDpp. Such uses include, but are not limited to diagnostic and therapeutic applications.
    Type: Application
    Filed: November 14, 2018
    Publication date: February 24, 2022
    Inventors: David M. HILBERT, Jeffrey S. SWERS
  • Publication number: 20210401891
    Abstract: D domain (DD) containing polypeptides (DDpp) that specifically bind targets of interest (e.g., BCMA, CD123, CS1, HER2, AFP, and AFP p26) are provided, as are nucleic acids encoding the DDpp, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. DDpp such as DDpp fusion proteins, are also provided as are methods of making and using the DDpp. Such uses include, but are not limited to diagnostic and therapeutic applications.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Inventors: David M. HILBERT, Jeffrey S. SWERS
  • Publication number: 20210403517
    Abstract: D domain (DD) containing polypeptides (DDpp) that specifically bind targets of interest (e.g., BCMA, CD123, CS1, HER2, AFP, and AFP p26) are provided, as are nucleic acids encoding the DDpp, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. DDpp such as DDpp fusion proteins, are also provided as are methods of making and using the DDpp. Such uses include, but are not limited to diagnostic and therapeutic applications.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Inventors: David M. HILBERT, Jeffrey S. SWERS
  • Publication number: 20210023133
    Abstract: Provided herein are multi-functional chimeric antigen receptor (CAR)-based compositions and their use in directing immune responses to target cells. The compositions have uses that include treating hyperproliferative disorders such as cancer. The provided methods generally include the use of a CAR cell in combination with an Adapter. The Adapter confers the ability to modulate, alter, and/or redirect CAR cell-mediated immune response in vitro and in vivo.
    Type: Application
    Filed: November 14, 2018
    Publication date: January 28, 2021
    Inventors: David M. HILBERT, Jeffrey S. SWERS, David William LAFLEUR