Abstract: The present disclosure relates to pharmaceutical compositions of adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).

Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles and AAV formulations, including recombinant adeno-associated virus (rAAV) particles and formulations. In certain embodiments, the present disclosure presents methods and systems for clarifying, purifying, formulating, filtering and processing AAV particles and AAV formulations. The present disclosure also describes compositions, methods and processes for the design, preparation, manufacture, use and/or formulation of AAV particles comprising modulatory polynucleotides, e.g., polynucleotides encoding small interfering RNA (siRNA) molecules which target the Huntingtin (HTT) gene (e.g., the wild-type or the mutated CAG-expanded HTT gene). Methods for using formulated AAV particles comprising modulatory polynucleotides to inhibit the HTT gene expression in a subject with a neurodegenerative disease (e.g., Huntington's Disease (HD)) are also disclosed.

Abstract: The present invention is directed to tool arrangement having a one piece frame. The one piece frame that is solid and non-adjustable and includes a back side, front side and one or more extension walls extending away from the front side of the one piece frame. An attachment portion is located on said back side of the one piece frame for connecting the tool arrangement to a robotic arm. The one piece frame has at least three mounting locations formed at predetermine locations on said one piece frame. The at least three mounting locations are predetermined and non-adjustable locations on the one piece frame. The tool arrangement includes a stationary gripper connected to one of the three mounting locations and at least one four point gripper connected to another one of the three mounting locations.

Abstract: The present invention is directed to tool arrangement having a one piece frame. The one piece frame that is solid and non-adjustable and includes a back side, front side and one or more extension walls extending away from the front side of the one piece frame. An attachment portion is located on said back side of the one piece frame for connecting the tool arrangement to a robotic arm. The one piece frame has at least three mounting locations formed at predetermine locations on said one piece frame. The at least three mounting locations are predetermined and non-adjustable locations on the one piece frame. The tool arrangement includes a stationary gripper connected to one of the three mounting locations and at least one four point gripper connected to another one of the three mounting locations.

Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.

Abstract: A robotic mower boundary sensing system includes a boundary driving circuit on a charging station transmitting an encoded signal on a boundary wire, a boundary sensor on a robotic mower and including an inductor receiving the encoded signal, and a vehicle control unit on the robotic mower receiving the encoded signal from the boundary sensor and decoding the signal and cross correlating the received signal to determine the distance of the boundary sensor from the boundary wire.

Abstract: A robotic mower boundary sensing system includes a boundary driving circuit on a charging station transmitting an encoded signal on a boundary wire, a boundary sensor on a robotic mower and including an inductor receiving the encoded signal, and a vehicle control unit on the robotic mower receiving the encoded signal from the boundary sensor and decoding the signal and cross correlating the received signal to determine the distance of the boundary sensor from the boundary wire.

Abstract: A robotic mower launch point system includes a user interface for an operator to enter a plurality of launch point locations, durations and frequencies, and a vehicle control unit that stores the locations, durations and frequencies, determines a sequence of launches based on the launch point frequencies, and commands the robotic mower to exit a charging station and follow a boundary wire to each launch point in the sequence where the robotic mower mows for that launch point's duration before returning to the charging station. The vehicle control determines the sequence based on the frequency of each launch point relative to a total of the launch point frequencies.

Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.

Abstract: A robotic mower home finding system includes a charging station connected to an outer boundary wire loop, and a vehicle control unit on the robotic mower that directs a traction drive system to drive the robotic mower along a path offset a specified distance from an outer boundary wire loop toward the charging station. The vehicle control unit changes the specified distance randomly or incrementally so that the robotic mower does not take the same path to the charging station each time.

Abstract: A robotic mower boundary sensing system includes a boundary driving circuit on a charging station transmitting an encoded signal on a boundary wire, a boundary sensor on a robotic mower and including an inductor receiving the encoded signal, and a vehicle control unit on the robotic mower receiving the encoded signal from the boundary sensor and decoding the signal and cross correlating the received signal to determine the distance of the boundary sensor from the boundary wire.

Abstract: A robotic mower launch point system includes a user interface for an operator to enter a plurality of launch point locations, durations and frequencies, and a vehicle control unit that stores the locations, durations and frequencies, determines a sequence of launches based on the launch point frequencies, and commands the robotic mower to exit a charging station and follow a boundary wire to each launch point in the sequence where the robotic mower mows for that launch point's duration before returning to the charging station. The vehicle control determines the sequence based on the frequency of each launch point relative to a total of the launch point frequencies.

Abstract: A system and method for positioning a mobile machine, such as a robot, using a tether line connected between two mobile machines. A first mobile machine, such as a boundary vehicle, is controlled to move along a path, such as a boundary defining an area. The first machine employs a localization device to determine and maintain its position on the path. A tether line is connected between the boundary vehicle and a second mobile machine, such as a roving vehicle. The first machine determines the position of the second machine relative to the first machine from a length of extension and angle of the tether line. The first machine controls movement of the second machine to perform a task or mission, such as a task performed in the area defined by the boundary.

Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.

Abstract: A robotic mower boundary sensing system includes a boundary driving circuit on a charging station transmitting an encoded signal on a boundary wire, a boundary sensor on a robotic mower and including an inductor receiving the encoded signal, and a vehicle control unit on the robotic mower receiving the encoded signal from the boundary sensor and decoding the signal and cross correlating the received signal to determine the distance of the boundary sensor from the boundary wire.

Abstract: A robotic mower home finding system includes a charging station connected to an outer boundary wire loop, and a vehicle control unit on the robotic mower that directs a traction drive system to drive the robotic mower along a path offset a specified distance from an outer boundary wire loop toward the charging station. The vehicle control unit changes the specified distance randomly or incrementally so that the robotic mower does not take the same path to the charging station each time.

Abstract: A robotic mower stuck detection system includes a boundary sensor on the robotic mower that can detect when the robotic mower reaches a boundary wire, an accelerometer on the robotic mower that can detect when the robotic mower encounters an obstacle; and a vehicle control unit on the robotic mower having a timer that is reset each time the robotic mower reaches a boundary wire or encounters an obstacle; and executes a stuck vehicle task if the timer exceeds a specified maximum time without being reset.

Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.

Abstract: A system and method for positioning a mobile machine, such as a robot, using a tether line connected between two mobile machines. A first mobile machine, such as a boundary vehicle, is controlled to move along a path, such as a boundary defining an area. The first machine employs a localization device to determine and maintain its position on the path. A tether line is connected between the boundary vehicle and a second mobile machine, such as a roving vehicle. The first machine determines the position of the second machine relative to the first machine from a length of extension and angle of the tether line. The first machine controls movement of the second machine to perform a task or mission, such as a task performed in the area defined by the boundary.

Abstract: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.