Abstract: The present invention relates to a novel and useful method for assaying compounds and agents for their ability to decrease or inhibit the activity of hematopoietic prostaglandin D2 synthase (hPGDS). Specifically, the present invention relates to assays for measuring the potency, specificity and toxicity of hPGDS inhibitors.

Abstract: Methods of determining the potency, specificity, and toxicity of microsomal prostaglandin E2 synthase inhibitors are provided that utilize one cell-based assay system.

Abstract: A rotatable sports board binding adapter includes a base plate that forms a series of lock holes, and a rotatable plate that is rotatably connected to the base plate and is configured to receive a binding. The rotatable plate has a locking mechanism configured to engage any one of the lock holes. The adapter includes one or more low friction elements disposed between the base plate and the rotatable plate. A method for changing a range of rotation of a binding on a sports board includes disengaging a rotation limiter, rotating the rotatable plate from a first range of rotation into a second range of rotation, and re-engaging the rotation limiter with the rotatable plate in the second range of rotation.

Abstract: Methods of determining the potency, specificity, and toxicity of microsomal prostaglandin E2 synthase inhibitors are provided that utilize one cell-based assay system.

Abstract: A base plate with a ring of holes is secured to any existing sports board. A flat rotatable plate, supporting a board boot binding, has a two-position spring-loaded locking shaft which locks down in one of the holes to secure the boot binding at a desired stationary angle and alternately locks up out of the holes for free rotation. A semicircular arc in one plate dividable into two smaller arcs by a movable stop limits rotation of a safety pin from the other plate alternately to one or the other of the smaller arcs. A downwardly extending ridge around the periphery of the rotatable plate overlaps the base plate.

Abstract: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.