Abstract: A piston for a pressure-reducing valve includes a tubular housing having an internal longitudinal bore extending from a first end to a second end. An exterior circumferential sealing disc sealing engages internal walls. The sealing disc has upper and lower faces generally perpendicular to a longitudinal axis. First fluid port(s) and second fluid port(s) extend through the tubular housing and into the longitudinal bore. A piston stem sealingly engages an internal surface of the longitudinal bore between the sealing disc and the second end to prevent the passage of fluid. The piston stem, together with a portion of the longitudinal bore, forms fluid passageway(s) that fluidly connect the first fluid port(s) with the second fluid port(s). The second fluid port(s) are inclined relative to the longitudinal axis and extend through at least a portion of the sealing disc, intersecting at least a portion of the upper face thereof.

Abstract: A piston for a pressure-reducing valve includes a tubular housing having an internal longitudinal bore extending from a first end to a second end. An exterior circumferential sealing disc sealing engages internal walls. The sealing disc has upper and lower faces generally perpendicular to a longitudinal axis. First fluid port(s) and second fluid port(s) extend through the tubular housing and into the longitudinal bore. A piston stem sealingly engages an internal surface of the longitudinal bore between the sealing disc and the second end to prevent the passage of fluid. The piston stem, together with a portion of the longitudinal bore, forms fluid passageway(s) that fluidly connect the first fluid port(s) with the second fluid port(s). The second fluid port(s) are inclined relative to the longitudinal axis and extend through at least a portion of the sealing disc, intersecting at least a portion of the upper face thereof.

Abstract: An automated detection and avoidance system that provides a pilot with high-fidelity knowledge of the aircraft's physical state, and notifies the pilot of any deviations in expected state based on predictive models. The automated detection and avoidance system may include a processor and a sensor payload operatively coupled to the processor to detect a non-cooperative obstacle within a first airspace adjacent the aircraft. The sensor payload may comprise a radar to radially scan the first airspace, and a camera to scan a second airspace within said first airspace.

Abstract: An automated detection and avoidance system that provides a pilot with high-fidelity knowledge of the aircraft's physical state, and notifies the pilot of any deviations in expected state based on predictive models. The automated detection and avoidance system may include a processor and a sensor payload operatively coupled to the processor to detect a non-cooperative obstacle within a first airspace adjacent the aircraft. The sensor payload may comprise a radar to radially scan the first airspace, and a camera to scan a second airspace within said first airspace.

Abstract: A heterojunction semiconductor field effect transistor HFET having a pair of layers of different semiconductor materials forming a quantum well within the structure to support the 2DEG. Source, drain and gate electrodes are disposed above the channel. The HFET has a predetermined transconductance. A transconductance control electrode varies an electric field within the structure under the channel to vary the shape of the quantum well and thereby the transconductance of the FET in accordance with a variable control signal fed to the transconductance control electrode.

Abstract: A heterojunction semiconductor field effect transistor HFET having a pair of layers of different semiconductor materials forming a quantum well within the structure to support the 2DEG. Source, drain and gate electrodes are disposed above the channel. The HFET has a predetermined transconductance. A transconductance control electrode varies an electric field within the structure under the channel to vary the shape of the quantum well and thereby the transconductance of the FET in accordance with a variable control signal fed to the transconductance control electrode.

Abstract: Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

Abstract: Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.

Abstract: Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

Abstract: Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

Abstract: Compounds that modulate GHS-R are described, for examples compounds formula (I)

Abstract: A pre-distorter that compensates for amplitude and phase distortion created by an amplifier. During a training session, the amplifier is stimulated with input signals of pre-selected amplitude and phase at various temperatures and the amplifier output is captured and converted into data sets. Polynomials are then fitted to the data sets and inverses of the polynomials are determined. The coefficients of the inverse polynomials are then saved for each temperature. During operation, the amplifier temperature is predicted based on the amplifier input signal and the coefficients associated with the predicted temperature are selected to be applied to the input signal to compensate for amplitude and phase distortion caused by the amplifier.

Abstract: Compounds that modulate GHS-R are described, for examples compounds formula (I)

Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: A pre-distorter that compensates for amplitude and phase distortion created by an amplifier. During a training session, the amplifier is stimulated with input signals of pre-selected amplitude and phase at various temperatures and the amplifier output is captured and converted into data sets. Polynomials are then fitted to the data sets and inverses of the polynomials are determined. The coefficients of the inverse polynomials are then saved for each temperature. During operation, the amplifier temperature is predicted based on the amplifier input signal and the coefficients associated with the predicted temperature are selected to be applied to the input signal to compensate for amplitude and phase distortion caused by the amplifier.

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Abstract: Compounds of formulas (I), (II), (III), and (IV) and methods of treating disorders by administering a compound of formula (I), (II), (III), or (IV) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.

Abstract: A predistorter is disclosed that predistorts an input signal based on one or more static coefficients that are representative of a non-linear distortion characteristic of an amplifier. The input signal is also processed based on a non-linear gain parameter that reduces an error metric between the input signal and a feedback signal. The nonlinear gain parameter adapts an amount of nonlinearity introduced by the predistorter. The non-linear gain adaptation is performed, for example, when the input voltage is above a threshold input voltage. The input signal can be processed by multiplying the input signal by the non-linear gain parameter followed by table-coefficient processing, or by both multiplying the input by the non-linear gain parameter followed by dividing the table-coefficient processed output signal by the same non-linear gain parameter. The input signal can also be processed based on a feedback gain parameter that compensates for a small-signal gain of the feedback loop.

Abstract: Compounds of formula (I) are described herein The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to treat obesity.